Reaction:JCGG-RAC0000610

JCGG ID

JCGG-RAC0000610

Submitter

The Noguchi Institute

Reaction ID

R-0000-000610

Regist Date

2012/06/21 16:14:57

REACTANT

MOLECULE ID

JCGG-COM0000628 (Reaction Tree)

Skeleton

JCGG-STR031555

Mol

1.26 mmol

MOLECULE ID

JCGG-COM0000633 (Reaction Tree)

Mol

1.51 mmol

MOLECULE ID

JCGG-COM0000129

Reactant Type

NIS

Mol

4.54 mmol

MOLECULE ID

JCGG-COM0000111

Reactant Type

TfOH

Mol

0.45 mmol

PRODUCT

MOLECULE ID

JCGG-COM0000637 (Reaction Tree)

Yield

64%

REACTION DETAIL

Reaction Time

6 hours, 20 minutes + 16 hours

Reaction Temp

room temp, -20 degree C

Solvent

dry CH3CN/CH2Cl2 = 5/1, dry CH3CN/CH2Cl2 = 5/1

Comment

1) 2+5, MS 3A, 2) +NIS, TfOH

TfOH was added 20 minutes after the initiation of the second phase.

COMMENT

There are two phases in this reaction.

REFERENCE

Reference Id

REF-0000-000028

Issn

Electronic

Doi

10.1021/jm8000696

PubMed ID

18841881

Journal Name

Journal of medicinal chemistry. (2008) 51 (21): 6665-81.

Article Title

Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors.

Author

Hajjaj H M, Abdu-Allah; Taichi, Tamanaka; Jie, Yu; Lu, Zhuoyuan; Magesh, Sadagopan; Takahiro, Adachi; Takeshi, Tsubata; Soerge, Kelm; Hideharu, Ishida; Makoto, Kiso

Affiliation

Department of Applied Bio-organic Chemistry, The United Graduate School of Agricultural Sciences, Gifu University, Gifu 501-1193, Japan.

Reference Id

REF-0000-000029

Source

J. Med. Chem., 2008, 51, 6665-6681

Doi

10.1021/jm8000696