JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
JCGG-RAC0000060
Submitter
The Noguchi Institute
Reaction ID
R-0000-000060
Regist Date
2012/06/21 13:01:09
REACTANT
MOLECULE ID
JCGG-COM0000088 (Reaction Tree)
Reactant Type
Starting suger derivative
Mol
0.54 mmol (1 equiv.)
MOLECULE ID
JCGG-COM0000089
Reactant Type
MeLi
Mol
0.64 mmol (1.2 equiv.)
MOLECULE ID
JCGG-COM0000086
Reactant Type
Ac2O
Mol
6 equiv.
Volume
0.6 mL
PRODUCT
MOLECULE ID
JCGG-COM0000087 (Reaction Tree)
Yield
73%
REACTION DETAIL
Reaction Time
1 hour
1 hour
Reaction Temp
-78 to -30 degree C
-30 to 0 degree C
Solvent
THF
THF
Comment
The addition of MeLi
The addition of Ac2O
Method B in Scheme 5
COMMENT
The PMID could not be found.
There are two phases in this reaction.
MeLi can be substituted with MeMgBr.
REFERENCE
Reference Id
REF-0000-000004
Source
Tetrahedron 62 (2006) 10383‐10392
Doi
10.1016/j.tet.2006.08.059

©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)