BacteriumFungusVirusToxin

Pathogen Adherence to Carbohydrate DB

This database provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants. Many pathogens have been reported to recognize the sugar moieties of host cells as a first step of bacterial adhesion and infection. We have also collected the data of diseases caused by bacterial infections to host tissues.

This database will give you easy access to the data on each pathogen and its receptor glycans or proteins.

We hope that this database could be of help in your study and serve as a bridge for two areas of study, glycoscience and infectious diseases.

Project Members

Masako Maeda, RCMG, AIST.

Mihou Fushimi (Graphic Design), RCMG, AIST.

Toshihide Shikanai, RCMG, AIST.

Hisashi Narimatsu, RCMG, AIST.

Disclaimer

Liability: For documents with data and tools available from this server, JCGGDB & AIST does not warrant or assume any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed.

Acknowledgements

This database is supported by Ministry of Education, Culture, Sports, Science and Technology (MEXT) as part of Life Science Integrated Database project.

Contents
PACDB is included below.
Version: 1.1 (Last updated on:March 1 2010)
Diseases : 99
Scientific Names: 129
Glycans and Glycoproteins: 101
Information on the interaction between Pathogen and Glycans (Glycoproteins): 1714
Extraction from 216 References



PACDB REF. IDPathogen Adherence MoleculeGlycan/Glycoprotein Ligand
5Actinobacillus pleuropneumoniae
(serotype 1:4074/serotype 2:4226)
Binding
Glycan-Glycan interaction:LPS		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
6Pseudomonas aeruginosa
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
6Burkholderia pseudomallei
Binding
Adhesin:Adhesins		Pharyngeal epithelial cells Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
6Burkholderia cepacia
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
10Escherichia coli
(Uropathogenic(UPEC); K12/HB101(pPIL110-54))
Binding
Adhesin:F1C
Genomic Name:foc (cluster of 8 genes)		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
10Pseudomonas aeruginosa
Binding
Fimbria:Fimbriae		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
10Neisseria gonorrhoeae
Binding
Unclassfied Protein:18-kDa proteins
Fimbria:Fimbriae		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
14Lactobacillus johnsonii
(La1)
Binding
Unclassfied Protein:Unknown		Guinea pig erythrocytes Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
21Escherichia coli
(Enterotoxigenic(ETEC); K88)
Binding
Adhesin:K88ab/K88ac/K88ad		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
24Moraxella catarrhalis
Binding
Fimbria:Fimbriae		Other than pharyngeal epithelial cells Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Escherichia coli
(6883)
Binding
Unclassfied Protein:Unknown
Adhesin:K99-fimbriae		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Neisseria gonorrhoeae
(MS11/ML1/LP1)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Rotavirus
(SA11/NCDV/UK)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Escherichia coli
(VJ1)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Chlamydia trachomatis
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Klebsiella pneumoniae
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Salmonella typhimurium
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Haemophilus influenzae
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Streptococcus pneumoniae
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Chlamydia pneumoniae
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Haemophilus parainfluenzae
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Pseudomonas cepacia
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
25Pseudomonas aeruginosa
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
28Legionella pneumophila
(CORBY)
Binding
Adhesin:Adhesins		Human epithelial cells (respiratory tract) Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
29Pseudomonas aeruginosa
Binding
Pili:Type 4-pili		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
34Bordetella pertussis
(virulent/avirulent)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
34Pseudomonas aeruginosa
Binding
Unclassfied Protein:Unknown		Cystic fibrosis patients Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
39Pseudomonas aeruginosa
(DG1)
Binding
Adhesin:Exoenzyme S		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
44Neisseria gonorrhoeae
(MS11/FA5100/WG-52)
Binding
Unclassfied Protein:36-kDa proteins		Mucos membranes of the genitourinary tract/rectum/oropharynx/conjunctiva Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
44Streptococcus pneumoniae
Binding
Adhesin:Adhesins		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
44Pseudomonas aeruginosa
Binding
Adhesin:Adhesins		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
44Haemophilus influenzae
Binding
Adhesin:Adhesins		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
47Actinomyces naeslundii
(ATCC 12104)
Binding
Unclassfied Protein:Unknown		Human brain Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
47Actinomyces viscosus
(ATCC 19246)
Binding
Unclassfied Protein:Unknown		Human brain Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
48Neisseria gonorrhoeae
Binding
Adhesin:Lectin-like proteins (adhesin)		Gonorrhoeae patients Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
48Propionibacterium granulosum
Binding
Adhesin:Lectin-like proteins (adhesin)		Human skin Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
49Mycoplasma pneumoniae
(M129; virulent)
Not Binding
Unclassfied Protein:Unknown		Human colon adenocarcinoma cells (WiDr ) Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Not Binding ]
53Streptococcus pyogenes
(12344)
Not Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Not Binding ]
53Staphylococcus aureus
(12600/8095)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
53Pseudomonas maltophilia
(13637)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
53Pseudomonas cepacia
(25416/ML1/13945)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
53Klebsiella pneumoniae
(27736)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
53Haemophilus influenzae
(33391/9795)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
53Haemophilus parainfluenzae
(33392)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
53Streptococcus pneumoniae
(33400/6303/27336)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
53Pseudomonas aeruginosa
(CT3/CT4/CT5/17648/19142/33347/21472)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
53Escherichia coli
(K1/K99 1472(B44))
Not Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Not Binding ]
53Mycoplasma pneumoniae
(M129)
Not Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Not Binding ]
53Salmonella enteritidis
(U4 4407-50/13076)
Not Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Not Binding ]
53Escherichia coli
(VJ1/6883)
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
55Shigella dysenteriae
(type1; 3818-O)
Not Binding
Unclassfied Protein:B subunit		Mouse small intestine Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Not Binding ]
60Escherichia coli
Not Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Not Binding ]
60Vibrio cholerae
Not Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Not Binding ]
61Pseudomonas aeruginosa
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
70Candida albicans
(40)
Binding
Unclassfied Protein:"Extracellular polymeric material, acid proteinase, chitin"
Fimbria:66-kDa subunit		Human buccal epihelial cells (BECs) Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
76Burkholderia cepacia
(BC5/BC7/BC61/NBC1/NBC2/NBC3)
Binding
Adhesin:Lectin-like proteins (adhesin)		Sputa of cystic fibrosis patients Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
76Burkholderia cepacia
(BC5/BC7/BC61/NBC1/NBC2/NBC3)
Binding
Adhesin:Lectin-like proteins (adhesin)		Sputa of cystic fibrosis patients Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
83Pseudomonas aeruginosa
Binding
Pili:Type 4-pili		Epithelial cells Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
83Pseudomonas aeruginosa
Binding
Adhesin:exoenzyme S		Epithelial cells Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
83Pseudomonas aeruginosa
Binding
Unclassfied Protein:Flagellin		Epithelial cells Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
87Helicobacter pylori
(1139/17874/17875/11637/11638)
Binding
Unclassfied Protein:35S-labeled or 125I-labeled proteins		Guinea pig erythrocytes Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
91Escherichia coli
(HB101(pDG1))
Binding
Adhesin:PsaA/B (pH-6 antigen)
Genomic Name:psaA/B		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
91Yersinia pestis
(pH6 antigen from Escherichia coli(HB101))
Binding
Adhesin:PsaA/B (pH-6 antigen)
Genomic Name:psaA/B		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
103Rotavirus
(Neuraminidase-insensitive; bovine:UK(P5/G6))
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
103Rotavirus
(Neuraminidase-sensitive; simian:SA11(P2/G3) / bovine:NCDV(P1/G6))
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
106Propionibacterium granulosum
Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
106Propionibacterium freudenreichii
Not Binding
Unclassfied Protein:Unknown		Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Not Binding ]
107Streptococcus pneumoniae
(R6; unencapsulated)
Binding
Adhesin:Adhesins		Type-II lung cells, Vascular endothelial cells Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
117Escherichia coli
(Uropathogenic(UPEC); ARD6; serotype O6:K13:H1)
Not Binding
Adhesin:F1C		Guinea pig erythrocytes Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Not Binding ]
121Pseudomonas aeruginosa
Binding
Unclassfied Protein:Unknown		Lung Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]
121Pseudomonas cepacia
Binding
Unclassfied Protein:Unknown		Lung Asialo GM2 (GgO3; GA2; gangliotriaosylceramide )
GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer [ Binding ]

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