JCGG-STR027066:JCGGDB ID

Glycan Information

Glyco Tree get Image

Composition

Descriptors Computed from Structure

Mass

Glycan Motifs

Motif ID	Structure / SubStructure Name	Note
JCGG-MOTIF3009	neolacto	Reducing Terminal
JCGG-MOTIF4062	Paragloboside	Reducing Terminal
JCGG-MOTIF4012	Sialyl Lewis x	NON-Reducing Terminal

Chemical Synthesis

ID History Deleted Version

Name:   sialyl-dimeric Lex
Description:   N-acetylneuraminyla2-3galactosylb1-4(fucosyla1-3)N-acetyl-glucosaminylb1-3galactosylb1-4(fucosyla1-3)N-acetyl-glucosaminylb1-3galactosylb1-4glucosylceramide
Reducing terminal:   (b-)Cer

GlycomeDB (Structure)

603

KEGG (Structure)

G00195

PACDB(Pathogen adhesion)

Pathogen:	Helicobacter pylori
Glycan Name:	Sialyl-dimeric Lewis x (SdiLex-HSA) [ Binding]

Pathogen:	Norovirus (GII3-Chron1 / GII4-Dijon)
Glycan Name:	Sialyl-dimeric Lewis x (SdiLex-HSA) [ Binding]

CarbBank

CCSD : 1543

Title : Structure of a novel sialylated fucosyl lacto-N-nor-hexaosylceramide isolated from chronic myelogenous leukemia cells

Authors : Fukuda MN; Dell A; Tiller PR; Varki A; Klock JC; Fukuda M

Info : J Biol Chem (1986) 261: 2376-2383

Other Data : colon Other Data : 2010-12-17

CCSD : 5227

Title : Proton NMR analysis of glycolipids possessing mono- and multimeric X and Y haptens: characterization of two novel extended Y structures from human adenocarcinoma

Authors : Levery SB; Nudelman ED; Andersen NH; Hakomori SI

Info : Carbohydr Res (1986) 151: 311-328

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : 2010-12-17

CCSD : 5433

Title : Specificity of fucose transfer to GlcNAc residues of extended chain neolacto-series glycolipids catalyzed by human .alpha.1-3fucosyltransferases: effect on the lipidic environment on the myeloid enzyme form

Authors : Holmes EH; Macher BA

Info : Arch Biochem Biophys (1993) 301: 190-199

Other Data : 2010-12-17

CCSD : 8138

Title : Monosialogangliosides of human myelogenous leukemia HL60 cells and normal human leukocytes. 1. Separation of E-selectin binding from nonbinding gangliosides, and absence of sialosyl-Lex having tetraosyl to octaosyl core

Authors : Stroud MR; Handa K; Ito K; Salyan MEK; Fang H; Levery SB; Hakomori S- I; Reinhold BB; Reinhold VN

Info : Biochemistry (1996) 35: 758-769

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : cell line:HL60 cell Other Data : 2010-12-17

CCSD : 9445

Title : Characterization of sialosylated Lewis x as a new tumor-associated antigen

Authors : Fukushima K; Hirota M; Terasaki PI; Wakisaka A; Togashi H; Chia D; Suyama N; Fukushi Y; Nudelman E; Hakomori S

Info : Cancer Res (1984) 44: 5279-5285

Other Data : 2010-12-17

CCSD : 9646

Title : Negative-ion fast atom bombardment and electrospray ionization tandem mass spectrometry for characterization of sulfated and sialyl Lewis-type glycosphingolipids

Authors : Ii T; Ohashi Y; Ogawa T; Nagai Y

Info : Glycoconj J (1996) 13: 273-283

Other Data : 2010-12-17

CCSD : 11996

Title : Novel fucolipids accumulating in human adenocarcinoma: III. A hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside (VI3NeuAcV3III3Fuc2nLc6)

Authors : Fukushi Y; Nudelman E; Levery SB; Hakomori S; Rauvala H

Info : J Biol Chem (1984) 259: 10511-10517

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : 2010-12-17

CCSD : 13990

Title : Glycosphingolipids of human umbilical vein endothelial cells and smooth muscle cells

Authors : Gillard BK; Jones MA; Marcus DM

Info : Arch Biochem Biophys (1987) 256: 435-445

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : umbilical endothelium Other Data : 2010-12-17

CCSD : 15286

Title : Proton NMR analysis of type-2 chain lactogangliosides. Confirmation of structure of a novel cancer-associated fucoganglioside, .alpha.-NeuAc-(2-6)- GlcpNAc-(1-3)-.beta.-D-Galp-(1-4)-.beta.-D-Glcp-(1-1)-Cer (VI6NeuAcIII3FucnLc6Cer)

Authors : Levery SB; Nudelman E; Kannagi R; Symington FW; Andersen NH; Clausen H; Baldwin M; Hakomori SI

Info : Carbohydr Res (1988) 178: 121-144

Other Data : 2010-12-17

CCSD : 16214

Title : Biosynthesis of the sialyl-Lex determinant carried by type 2 chain glycosphingolipids (IV3NeuAcIII3FucnLc4, VI3NeuAcV3FucnLc6, and VI3NeuAcIII3V3Fuc2nLc6) in human lung carcinoma PC9 cells

Authors : Holmes EH; Ostrander GK; Hakomori S

Info : J Biol Chem (1986) 261: 3737-3743

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : lung Other Data : 2010-12-17

CCSD : 16415

Title : Oncofetal expression of Lex carbohydrate antigens in human colonic adenocarcinomas. Regulation through type 2 core chain synthesis rather than fucosylation

Authors : Holmes EH; Ostrander GK; Clausen H; Graem N

Info : J Biol Chem (1987) 262: 11331-11338

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : colon Other Data : 2010-12-17

CCSD : 16458

Title : Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed .beta.1-3N-acetylglucosaminyltransferase

Authors : Holmes EH; Hakomori S; Ostrander GK

Info : J Biol Chem (1987) 262: 15649-15658

Other Data : 2010-12-17

CCSD : 17174

Title : Hybridomas producing monoclonal antibodies to difucogangliosides attached to human cancer

Authors :

Info : Jpn Kokai Tokkyo Koho (1987) : 1-20

Other Data : 2010-12-17

CCSD : 17869

Title : Cancer-associated serum glycoprotein antigens expressing type 1 and type 2 chain polylactosamines

Authors : Kannagi R; Hakomori S; Imura H

Info : UCLA Symp Mol Cell Biol New Ser (1988) 79: 279-294

Other Data : 2010-12-17

CCSD : 18447

Title : Interferon-gamma alters expression of endothelial cell-surface glycosphingolipids

Authors : Gillard BK; Jones MA; Turner AA; Lewis DE; Marcus DM

Info : Arch Biochem Biophys (1990) 279: 122-129

Other Data : 2010-12-17

CCSD : 26187

Title : ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex

Authors : Phillips ML; Nudelman E; Gaeta FCA; Perez M; Singhal AK; Hakomori SI; Paulson JC

Info : Science (1990) 250: 1130-1132

Other Data : 2010-12-17

CCSD : 33727

Title : Structure and function of sphingoglycolipids in transmembrane signalling and cell-cell interactions

Authors : Hakomori SI

Info : Biochem Soc Trans (1993) 21: 583-595

Other Data : 2010-12-17

CCSD : 36120

Title : Glycosphingolipid tumor antigens

Authors : Fredman P

Info : Adv Lipid Res (1993) 25: 213-234

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : gastric, colon, lung, breast, kidney Other Data : 2010-12-17

CCSD : 46995

Title : Serological and immunohistochemical studies on sialylated carbohydrate antigens in colorectal carcinoma

Authors : Nakagoe T; Kusano H; Hirota M; Fukushima K; Hiratani K; Hara K; Tomita M

Info : Gastroenterol Jpn (1991) 26: 303-311

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : serum Other Data : 2010-12-17

CCSD : 48129

Title : A total synthesis of sialyl dimeric Le x ganglioside

Authors : Kameyama A; Ehara T; Yamada Y; Ishida H; Kiso M; Hasegawa A

Info : J Carbohydr Chem (1995) 14: 507-523

Other Data : 2010-12-17

JCGGDB ID JCGG-STR027066

Glycan Information

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