JCGG-STR012155:JCGGDB ID

JCGGDB Glycan Structure Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)

Glycan Information

Glyco Tree get Image

Composition

Hex 3 HexNAc 1 Neu5Gc 1
Mass Value Search

Gal 2 Glc 1 GlcNAc 1 Neu5Gc 1
Structural Isomer Search

Descriptors Computed from Structure

InChIKey	NRXNZIRNIREFQL-DSKNEWALSA-N
InChI	InChI=1S/C37H62N2O30/c1-9(46)38-18-22(53)27(15(7-44)64-33(18)67-30-20(51)12(4-41)62-34(25(30)56)66-28-14(6-43)61-32(58)24(55)23(28)54)65-35-26(57)31(21(52)13(5-42)63-35)69-37(36(59)60)2-10(47)17(39-16(49)8-45)29(68-37)19(50)11(48)3-40/h10-15,17-35,40-45,47-48,50-58H,2-8H2,1H3,(H,38,46)(H,39,49)(H,59,60)/t10-,11+,12+,13+,14+,15+,17+,18+,19+,20-,21-,22+,23+,24+,25+,26+,27+,28+,29+,30-,31-,32+,33-,34-,35-,37-/m0/s
SMILES	CC(=O)N[C@@H]1[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O[C@@]3(C[C@H](O)[C@@H](NC(=O)CO)[C@@H](O3)[C@H](O)[C@H](O)CO)C(O)=O)[C@H]2O)[C@@H](CO)O[C@H]1O[C@H]1[C@@H](O)[C@@H](CO)O[C@@H](O[C@@H]2[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]2O)[C@@H]1O

Mass

	Monoisotopic Mass	Average Mass
Underivatised Oligosaccharides	1014.3386	1014.8947
Permethylated Oligosaccharides	1294.6517	1295.4323
Peracetylated Oligosaccharides	1728.5183	1729.5283

Glycan Motifs

Motif ID	Structure / SubStructure Name	Note
JCGG-MOTIF3009	neolacto	Reducing Terminal
JCGG-MOTIF4062	Paragloboside	Reducing Terminal
JCGG-MOTIF4125	Neu5Gc(a2-3)Gal(b1-4)GlcNAc	NON-Reducing Terminal

External Links

GlycoEpitope (Antiglycan Antibody)

GlycoEpitope GLPD-000114 GLPD-000114

Name:   (Neu5Gc)Sialylparagloboside
Description:   IV³Neu5GcnLc₄Cer
Reducing terminal:   (b-1)Cer

JCGG	JCGG JGD-000627 JGD-000627 Reducing terminal: (b-1)Cer

GlycomeDB (Structure)

GlycomeDB 2128 2128

KEGG (Structure)

KEGG G00332 G00332

PACDB(Pathogen adhesion)

Pathogen:	Escherichia coli (Enterotoxigenic(ETEC); K99)
Glycan Name:	NeuGc3-nLc4 (sialyl paragloboside) [ Binding]

Pathogen:	Influenza virus (A/PR/8/34; H1N1; human)
Glycan Name:	NeuGc3-nLc4 (sialyl paragloboside) [ Not Binding]

Pathogen:	Influenza virus (B/Lee/40; human)
Glycan Name:	NeuGc3-nLc4 (sialyl paragloboside) [ Not Binding]

Pathogen:	Influenza virus (C/Ann Arbor/1/50; human)
Glycan Name:	NeuGc3-nLc4 (sialyl paragloboside) [ Not Binding]

Pathogen:	Helicobacter pylori
Glycan Name:	NeuGc3-nLc4 (sialyl paragloboside) [ Not Binding]

CarbBank

CCSD : 7580

Title : Calf small intestine receptors for K99 fimbriated enterotoxigenic Escherichia coli

Authors : Teneberg S; Willemsen PTJ; De Graaf FK; Karlsson KA

Info : FEMS Microbiol Lett (1993) 109: 107-112

TAXID : 9986 Other Data : thymus Other Data : 2010-12-17

CCSD : 9148

Title : Gangliosides of hog skeletal muscle

Authors : Nakamura K; Nagashima M; Sekine M; Igarashi M; Ariga T; Atsumi T; Miyatake T; Suzuki A; Yamakawa T

Info : Biochim Biophys Acta (1983) 752: 291-300

TAXID : 9823 Other Data : muscle Other Data : 2010-12-17

CCSD : 13630

Title : Topochemische anordnung von gangliosiden in der erythrozyten membrane

Authors : Wintzer G; Uhlenbruck G

Info : Z Immun Allerg Klin Immunol (1967) 133: 60-67

TAXID : 9823 Other Data : erythrocyte Other Data : 2010-12-17

CCSD : 13660

Title : Gangliosides of Extraneural Organs

Authors : Wiegandt H

Info : Z Physiol Chem (1973) 354: 1049-1056

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : 2010-12-17

CCSD : 14484

Title : Specific staining on thin-layer chromatograms of glycosphingolipids of neolacto series and gangliosides with a terminal N-acetylneuraminyl residue by different procedures with wheat germ agglutinin

Authors : Higashi H; Sugii T; Kato S

Info : Biochim Biophys Acta (1988) 963: 333-339

Other Data : 2010-12-17

CCSD : 15869

Title : Microstructure of the sialic acid moiety of N- glycolylneuraminyllactosylceramide and the elucidation of Hanganutziu and Deicher (HD) antigenicity

Authors : Mukuria JC; Naiki M; Kato S

Info : Immunol Lett (1986) 12: 165-169

Other Data : 2010-12-17

CCSD : 15893

Title : Interaction of Mycoplasma pneumoniae with erythrocyte glycolipids of I and i antigen types

Authors : Loomes LM; Uemura K; Feizi T

Info : Infect Immun (1985) 47: 15-20

Other Data : 2010-12-17

CCSD : 16047

Title : Specificities of human heterophile Hanganutziu and Deicher (HD) antibodies to glycosphingolipids and a glycoprotein

Authors : Mukuria CJ; Fujii Y; Kato S; Naiki M

Info : J Biochem (1986) 100: 469-475

Other Data : 2010-12-17

CCSD : 16686

Title : Analysis of the expression of N-glycolylneuraminic acid-containing gangliosides in cells and tissues using two human monoclonal antibodies

Authors : Furukawa K; Yamaguchi H; Oettgen HF; Old LJ; Lloyd KO

Info : J Biol Chem (1988) 263: 18507-18512

Other Data : 2010-12-17

CCSD : 17098

Title : Occurrence of tumor-associated ganglioside antigens with Hanganutziu- Deicher antigenic activity on human melanomas

Authors : Hirabayashi Y; Higashi H; Kato S; Taniguchi M; Matsumoto M

Info : Jpn J Cancer Res (1987) 78: 614-620

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : 2010-12-17

CCSD : 17115

Title : Establishment of a human monoclonal antibody to Hanganutziu-Deicher antigen as a tumor-associated carbohydrate antigen

Authors : Usuba O; Fujii Y; Miyoshi I; Naiki M; Sendo F

Info : Jpn J Cancer Res (1988) 79: 1340-1348

Other Data : 2010-12-17

CCSD : 18401

Title : Escherichia coli K99 binds to N-glycolylsialoparagloboside and N- glycolyl-GM3 found in piglet small intestine

Authors : Kyogashima M; Ginsburg V; Krivan HC

Info : Arch Biochem Biophys (1989) 270: 391-397

Other Data : 2010-12-17

CCSD : 19354

Title : Had-1, a uridine 5'-diphosphogalactose transport-defective mutant of mouse mammary tumor cell FM3A: composition of glycolipids, cell growth inhibition by lactosylceramide, and loss of tumorigenicity

Authors : Taki T; Ogura K; Rokukawa C; Hara T; Kawakita M; Endo T; Kobata A; Handa S

Info : Cancer Res (1991) 51: 1701-1707

TAXID : 10090 Other Data : mammary tumor Other Data : 2010-12-17

CCSD : 20656

Title : The role of glycosphingolipids in natural immunity. Gangliosides modulate the cytotoxicity of natural killer cells

Authors : Bergel'son LD; Dyatlovitskaya EV; Klyuchareva TE; Kryukova EV; Lemenovskaya AF; Matveeva VA; Sinitsyna EV

Info : Eur J Immunol (1989) 19: 1979-1983

Other Data : 2010-12-17

CCSD : 21087

Title : Ganglioside epitope recognized by K99 fimbriae from enterotoxigenic Escherichia coli

Authors : Ono E; Abe K; Nakazawa M; Naiki M

Info : Infect Immun (1989) 57: 907-911

TAXID : 562 Other Data : 2010-12-17

CCSD : 21277

Title : Differential exposure of the major gangliosides in rabbit thymocytes to Vibrio cholerae neuraminidase

Authors : Iwamori M; Kawaguchi T; Nagai Y

Info : J Biochem (1989) 105: 723-727

Other Data : 2010-12-17

CCSD : 21296

Title : A simple and specific assay of glycosyltransferase and glycosidase activities by an enzyme-linked immunosorbent assay method, and its application to assay of galactosyltransferase activity in sera from patients with cancer

Authors : Taki T; Nishiwaki S; Ishii K; Handa S

Info : J Biochem (1990) 107: 493-498

Other Data : 2010-12-17

CCSD : 22272

Title : Single-amino-acid substitution in an antigenic site of influenza virus hemagglutinin can alter the specificity of binding to cell membrane- associated gangliosides

Authors : Suzuki Y; Kato H; Naeve CW; Webster RG

Info : J Virol (1989) 63: 4298-4302

Other Data : 2010-12-17

CCSD : 23082

Title : Regional distribution and sex difference in the acidic glycolipids of porcine kidney

Authors : Matsumoto H

Info : Teikyo Igaku Zasshi (1989) 12: 153-166

TAXID : 9823 Other Data : kidney Other Data : 2010-12-17

CCSD : 23158

Title : Glycolylneuraminic acid-containing sugar chain monoclonal antibody and method of manufacturing hybridoma producing the same

Authors : Yamasaki M; Nagai Y

Info : US Pat Appl (1990) : 1-16

Other Data : 2010-12-17

CCSD : 25290

Title : Analysis of autoantibodies to glycolipids on thymocytes in New Zealand Black mice

Authors : Ishii N; Watanabe K

Info : Immunology (1989) 68: 215-220

TAXID : 10090 Other Data : 2010-12-17

CCSD : 25529

Title : Adhesion of Mycoplasma pneumoniae to sulfated glycolipids and inhibition by dextran sulfate

Authors : Krivan HC; Olson LD; Barile MF; Ginsburg V; Roberts DD

Info : J Biol Chem (1989) 264: 9283-9288

Other Data : 2010-12-17

CCSD : 26068

Title : Detection of 4-O-acetyl-N-glycolylneuraminyl lactosylceramide as one of tumor-associated antigens in human colon cancer tissues by specific antibody

Authors : Miyoshi I; Higashi H; Hirabayashi Y; Kato S; Naiki M

Info : Mol Immunol (1986) 23: 631-638

Other Data : 2010-12-17

CCSD : 32882

Title : Full activation without calmodulin of calmodulin-dependent cyclic nucleotide phosphodiesterase by acidic glycosphingolipids: GM3, sialosylneolactotetraosylceramide and sulfatide

Authors : Higashi H; Yamagata T

Info : FEBS Lett (1992) 314: 53-57

Other Data : 2010-12-17

CCSD : 35167

Title : Adhesion of K99 fimbriated Escherichia coli to pig intestinal epithelium: correlation of adhesive and non-adhesive phenotypes with the sialoglycolipid content

Authors : Seignole D; Mouricout M; Duval-Iflah Y; Quintard B; Julien R

Info : J Gen Microbiol (1991) 137: 1591-1601

TAXID : 9823 Other Data : intestine brush border membrane Other Data : 2010-12-17

CCSD : 36636

Title : Two human monoclonal antibodies reacting with the major gangliosides of human melanomas and comparison with corresponding mouse monoclonal antibodies

Authors : Furukawa K; Yamaguchi H; Oettgen HF; Old LJ; Lloyd KO

Info : Cancer Res (1989) 49: 191-196

Other Data : 2010-12-17

CCSD : 40687

Title : Sialidase of swine influenza A viruses: variation of the recognition specificities for sialyl linkages and for the molecular species of sialic acid with the year of isolation

Authors : Xu G; Suzuki T; Maejima Y; Mizoguchi T; Tsuchiya M; Kiso M; Hasegawa A; Suzuki Y

Info : Glycoconj J (1995) 12: 156-161

Other Data : 2010-12-17

CCSD : 40806

Title : Production of monoclonal antibodies directed to Hanganutziu-Deicher active gangliosides, N-glycolylneuraminic acid-containing gangliosides

Authors : Watarai S; Kushi Y; Shigeto R; Misawa N; Eishi Y; Handa S; Yasuda T

Info : J Biochem (1995) 117: 1062-1069

Other Data : 2010-12-17

CCSD : 43395

Title : Potential use of specific human and chicken antibodies for detection of Hanganutziu-Deicher antigen(s) in sera of cancer patients

Authors : Mukuria CJ; Noguchi A; Suzuki E; Naiki M

Info : Jpn J Med Sci Biol (1994) 47: 253-264

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : serum Other Data : 2010-12-17

CCSD : 47383

Title : Two chicken monoclonal antibodies specific for heterophil Hanganutziu- Deicher antigens

Authors : Asaoka H; Nishinaka S; Wakamiya N; Matsuda H; Murata M

Info : Immunol Lett (1992) 32: 91-96

Other Data : 2010-12-17

JCGGDB ID JCGG-STR012155

Glycan Information

External Links