| Name | Definition | IS_A |
|---|---|---|
| accumulated germline cell corpses | "Animals exhibit an increase in the quantity of germ line cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712] |
WBPhenotype:0000241:accumulated cell corpses |
| actin cytoskeleton filament morphology variant | "Animals exhibit variations in the form, structure, composition or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0001587:actin organization biogenesis variant |
| activity level variant | "Any variation in the degree of movement compared to control animals." [WB:cab] |
WBPhenotype:0000643:locomotion variant |
| age associated fluorescence increased | "Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control." [WB:WBPaper00033040, WB:WBPerson2021] |
WBPhenotype:0001009:developmental pigmentation variant |
| amplitude of sinusoidal movement increased | "Animals exhibit an increase in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0004022:amplitude of sinusoidal movement variant |
| anoxia hypersensitive | "Animals respond to anoxic (trace oxygen levels) stress after a shorter exposure time compared to control." [WB:WBPerson2021] |
WBPhenotype:0000464:oxygen response variant |
| apoptosis fails to occur | "Cells do not undergo the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes." [WB:WBPerson712] |
WBPhenotype:0000182:apoptosis reduced |
| apoptosis reduced | "Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals." [GO:0043065, WB:WBPerson2021] |
WBPhenotype:0000730:apoptosis variant |
| apoptosis variant | "Animals exhibit variations in any processes that influence the programmed cell death pathway. Induction of the apoptotic pathway triggers the activity of proteolytic caspases, which in turn lead to the destruction of the cell." [GO:0006915, WB:WBPerson2021] |
WBPhenotype:0001172:programmed cell death variant |
| avoids bacterial lawn | "Lawn avoidance refers to behavior in which animals initially enter the bacterial lawn but later exit and remain near the edge of the bacteria. Lawn avoidance is often a response to bacterial food, that is pathogenic or low quality to the animal." [WB:WBPaper00029071, WB:WBPerson2021] |
WBPhenotype:0000659:feeding behavior variant |
| axon branching variant | "Animals display variations in the number or pattern of axonal tracts stemming from the neuron cell body, compared to that observed in control animals." [GO:0048755, WB:WBPaper00027335, WB:WBPaper00027711, WB:WBPerson712] |
WBPhenotype:0000180:axon morphology variant WBPhenotype:0001224:axon outgrowth variant |
| axon fasciculation variant | "The ability of axons to converge and form a bundle of nerve fibres (fascicle) is compromised." [GO:0007413, WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000880:axon development variant |
| axon guidance variant | "Variations in the cue-directed extension of an axon towards a specific target site compared to control. (Axon guidance often depends on a combination of attractive and repulsive cues)." [GO:0048846, WB:WBPerson2021] |
WBPhenotype:0001224:axon outgrowth variant |
| axon midline crossing variant | "Regulated ventral midline crossing by axons vary either in the frequency of crossing events or the maintenance through development of process positions compared to control." [GO:0016199, WB:WBPaper00032007, WB:WBPerson712] |
WBPhenotype:0000384:axon guidance variant |
| axon morphology variant | "Animals display variations in the structure, organization of components, or spatial pattern of the projection that conducts signal away from the cell body, compared to that observed in control animals." [GO:0030424, WB:WBPaper00005236, WB:WBPerson712] |
WBPhenotype:0001398:neurite morphology variant |
| axon trajectory variant | "Animals display variations in the directed path taken by the axon compared to the path the nerve fiber follows in the nervous system in control animals." [WB:WBPaper00001105, WB:WBPerson712] |
WBPhenotype:0000180:axon morphology variant |
| Bacillus thuringiensis toxin hypersensitive | "Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] |
WBPhenotype:0000010:drug hypersensitive |
| Bacillus thuringiensis toxin resistant | "Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals." [GO:0042493, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557] |
WBPhenotype:0000011:drug resistant |
| backing decreased | "Animals spend less time backing compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0001005:backward locomotion variant |
| backward point velocity decreased | "Animals exhibit decreased velocity of backward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0002323:backward point velocity variant |
| bacterially unswollen | "Animals do not exhibit tail-swelling in response to infection by a bacterial pathogen (such as Microbacterium nematophilum) compared to control." [WB:cab, WB:WBPaper00026735] |
WBPhenotype:0000073:tail morphology variant WBPhenotype:0001014:pathogen resistance increased |
| biofilm absent head | "Animals can move thorough a lawn of bacterially produced biofilm without accumulating an enormous amount of biofilm on its nose. When C. elegans is exposed to certain bacteria (e.g., Y. pestis), a biofilm accumulates on a worm's head. The presence of this biofilm inhibits feeding by the worm, and thereby prevents growth." [WB:cab, WB:WBPaper00005238] |
WBPhenotype:0001415:pathogen adherence variant |
| bivulva | "Animals exhibit a secondary vulval invagination that is anterior or posterior to the primary opening depending on the the inappropriate placement of daughter cells along the anterior/posterior axis during vulval development." [WB:WBPaper00040151, WB:WBPerson712] |
WBPhenotype:0000695:vulva morphology variant |
| bleach hypersensitive | "Animals respond to bleach at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] |
WBPhenotype:0000524:bleach response variant |
| bloated | "Worms appears turgid or swollen as a result of an excess number of eggs being retained in the uterus." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000545:egg retention |
| body elongation variant | "Any variation in the elongation of embryonic epidermal cells compared to control. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000749:embryonic development variant |
| body morphology variant | "Animals exhibit variations in the form, structure or composition of any portion of their anatomy between the head and the tail compared to control animals." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000582:organism segment morphology variant |
| body posture amplitude decreased | "Animals exhibit variations in body posture caused by a decrease in the extent of displacement measured from the mean position to an extreme position compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0002291:body posture amplitude variant |
| body posture wavelength decreased | "Animals exhibit variations in body posture caused by a decrease in the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0002294:body posture wavelength variant |
| body size variant | "Animals exhibit variations in the physical dimensions of its body compared to control animals of the same developmental stage." [WB:WBPerson712] |
WBPhenotype:0000072:body morphology variant |
| body wall muscle morphology variant | "Any variation in the morphological appearance of the body wall muscle compared to control animals." [WB:WBPerson557] |
WBPhenotype:0000924:striated muscle morphology variant |
| body wall muscle myosin organization defective | "The characteristic organization of myosin filaments into discrete A-bands within the muscle cells is disrupted. In C. elegans, myosin filaments no longer appear as continuous longitudinally oriented fibers across the muscle quadrants." [WB:WBPaper00001894, WB:WBPerson2021] |
WBPhenotype:0000782:body wall muscle thick filament variant |
| body wall muscle sarcomere morphology variant | "Any variation in the form, structure or composition of the repeating units of a myofibrils in a muscle cell that are composed of an array of overlapping thick and thin filaments, compared to control." [GO:0030017, WB:WBPerson557] |
WBPhenotype:0000926:body wall muscle morphology variant |
| brood size variant | "The number of offspring produced is altered compared to that of control animals." [WB:WBPerson557] |
WBPhenotype:0000806:hermaphrodite fertility variant |
| carbohydrate metabolism variant | "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of carbohydrates within the organism or cell compared to control." [WB:WBPaper00038233, WB:WBPerson557, WB:WBPerson712] |
WBPhenotype:0000027:organism metabolism processing variant |
| cell division variant | "Any variation that alters the physical partitioning and separation of a cell into daughter cells compared to control." [GO:0051301, WB:WBPerson2021] |
WBPhenotype:0000536:cell physiology variant |
| cell fate transformation | "The cell takes on a different identity from which it was initially committed." [GO:0045165, WB:WBPaper00002924, WB:WBPerson712] |
WBPhenotype:0000216:cell fate specification variant |
| cell homeostasis metabolism variant | "Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the cell compared to control." [GO:0019725, WB:WBPerson2021] |
WBPhenotype:0000536:cell physiology variant |
| cell membrane organization biogenesis variant | "Variations in the process(es) involved in the assembly, transport, arrangement or disassembly of cell membrane structures or components compared to control." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0010002:cell organization biogenesis variant |
| cell morphology variant | "Any variation in the form or composition of the basic structural and functional unit of all organisms compared to control. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GO:0005623, WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000520:morphology variant |
| chemical response variant | "Animals exhibit variations in their response to a specific chemical compared to that observed in control animals." [WB:WBPerson557] |
WBPhenotype:0000738:organism environmental stimulus response variant |
| chondroitin biosynthesis variant | "Animals exhibit variations in the chemical reactions and pathways resulting in the formation of chondroitin sulfate compared to control." [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712] |
WBPhenotype:0001696:biosynthesis variant |
| chromosome condensation variant | "Any variation in the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells compared to control." [GO:0030261, WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0001743:mitosis variant WBPhenotype:0002012:meiotic chromosome organization variant |
| clear | "Animals appear unusually transparent when compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654] |
WBPhenotype:0000527:organism pigmentation variant |
| coiling frequency increased | "Animals spend more time with their body posture in a coil or they increase the frequency with which they form coils compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0002298:coiling frequency |
| comma arrest emb | "Cessation of development during the middle stage in embryogenesis of the worm in which the embryo is slightly folded within the eggshell (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000864:early elongation arrest |
| commissure handedness defective | "Outgrowth of the commissure occurs on the side of the body different from that observed in control animals." [WB:WBPaper00032007, WB:WBPerson712] |
WBPhenotype:0000181:axon trajectory variant WBPhenotype:0000384:axon guidance variant |
| cord commissures fail to reach target | "Axon tracts fail to complete the connection between nerve cords. In C. elegans, these tracts grow circumferentially around the animal, completing the connection between the ventral and dorsal nerve cords." [WB:WBPaper00001499, WB:WBPaper00028984, WB:WBPerson712] |
WBPhenotype:0000014:cord commissures variant |
| cortical dynamics defective early emb | "Little/no cortical ruffling or pseudocleavage furrow, or excessive cortical activity. In C. elegans, this is often characterized at the two-cell stage." [WB:cab, WB:cgc7141] |
WBPhenotype:0000764:embryonic cell organization biogenesis variant WBPhenotype:0001100:early embryonic lethal |
| cuticle carbohydrate surface variant | "Animals exhibit an altered display of glycosylated proteins or lipids or altered access to glycosylated moieties along their surface from that observed in control animals of the same developmental stage. In C. elegans, variations in surface accessible glycosylated species are often revealed by altered lectin-binding from that observed in control animals." [WB:WBPaper00001576, WB:WBPerson712] |
WBPhenotype:0001210:pericellular component physiology variant |
| cuticle development variant | "Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000200:pericellular component development variant |
| cuticle fragile | "The strength of the cuticle is less robust than that observed for control animals. In C. elegans the strength of the cuticle is often assayed by it's ability to protect the animal from exposure to bleach or other compounds." [WB:WBPerson712] |
WBPhenotype:0001211:cuticle integrity variant |
| cuticle morphology variant | "Any variation in the appearance or structure of the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000912:pericellular component morphology variant |
| cytokinesis defective early emb | "Cytokinesis is abnormal in the first or second stages of cell division." [WB:cab, WB:cgc7141] |
WBPhenotype:0001018:cytokinesis variant emb WBPhenotype:0001100:early embryonic lethal |
| cytokinesis variant emb | "Any variation that disrupts the cytoplasmic division of a cell during embryonic development compared to control." [GO:0000910, WB:WBPerson2021] |
WBPhenotype:0000050:embryonic lethal WBPhenotype:0000746:cell division variant |
| cytoplasmic processing body variant | "Discrete foci within the cytoplasm containing congregations of mRNA translational suppression and degradation mechanisms vary in their arrangement, clustering or are otherwise not well-defined compared to control." [WB:WBPaper00031914, WB:WBPaper00032172, WB:WBPerson712] |
WBPhenotype:0001300:germ cell cytoplasmic morphology variant |
| cytoskeleton organization biogenesis variant | "Animals exhibit variations in the form, structure, composition or arrangement of any of the various filamentous elements that form the internal framework of cells, compared to control. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GO:0005856, WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0001344:organelle organization biogenesis variant |
| dauer lifespan extended | "The life span of dauer-staged animals is longer than that observed in control dauer animals." [WB:WBPaper00032396, WB:WBPerson2987] |
WBPhenotype:0001540:dauer lifespan variant |
| dendrite development variant | "Any variation in the processes that influence the generation of neuronal extensions, that carry afferent (incoming) action potentials towards the cell body compared to control." [GO:0016358, WB:WBPerson2021] |
WBPhenotype:0000944:neurite development variant |
| developmental delay | "The developmental progression of an animal over time, from its formation to its mature structure is delayed compared to control." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000438:retarded heterochronic variations |
| diakinesis progression during oogenesis variant | "Developing oocytes show defects in their entry, progression through or exit from the diakinesis stage compared to control animals. Diakinesis is a cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [GO:0000241, WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001824:meiotic progression prophase variant |
| diakinesis region organization variant | "Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diakinesis stage. In C. elegans the diakinesis region occurs in the proximal gonad arm and is preceded by the diplotene region. In the diakinesis region oocytes arrest until oocyte maturation occurs." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001355:gonad morphology variant WBPhenotype:0001948:diakinesis progression during oogenesis variant |
| diplotene absent during oogenesis | "The diplotene stage is not observed in developing oocytes. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GO:0000240, WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001947:diplotene progression during oogenesis variant |
| diplotene progression during oogenesis variant | "Developing oocytes show defects in their entry, progression through or exit from the diplotene stage compared to control animals. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GO:0000240, WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001824:meiotic progression prophase variant |
| diplotene region organization variant | "Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diplotene stage. In C. elegans the diplotene region follows the pachytene region and occurs just distal to, and coincident with, the loop in the gonad arm. In the diplotene region germ cell compartments become organized into a single file." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001355:gonad morphology variant WBPhenotype:0001947:diplotene progression during oogenesis variant |
| distal tip cell migration variant | " Variations in the migration pattern of distal tip cells compared to control animals. In C. elegans, DTCs located on the anterior and posterior ends of the gonad primordium typically migrate in a symmetrical U-shaped pattern." [GO:0040039, WB:WBPaper00003598, WB:WBPerson2021] |
WBPhenotype:0000594:cell migration variant |
| drug hypersensitive | "Animals respond to a specific drug at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] |
WBPhenotype:0000631:drug response variant |
| drug resistant | "Animals fail to respond to the concentration of a drug that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Animals are not affected by exposure to the drug." [WB:WBPerson557] |
WBPhenotype:0000631:drug response variant |
| dumpy | "Worms are shorter and stouter than control animals at the same developmental stage." [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497] |
WBPhenotype:0001726:body length variant WBPhenotype:0001727:body width variant |
| early embryonic lethal | "Animal dies prior to the gastrulation stage of embryogenesis." [WB:WBPerson2021] |
WBPhenotype:0000050:embryonic lethal |
| early larval arrest | "Larvae arrest during early larval development. In C. elegans, this occurs during the L1 or L2 stages of larval development." [WB:cab] |
WBPhenotype:0000059:larval arrest |
| early larval lethal | "Animals die during early larval development. In C.elegans, this occurs during the L1- L2 larval stages of the life cycle." [WB:WBPerson2021] |
WBPhenotype:0000054:larval lethal |
| ectopic neurite outgrowth | "Any variation that causes an increase in the frequency of neurite (axon or dendrite) outgrowth. As a result, an excess number of neuronal projections are generated." [WB:WBPerson2021] |
WBPhenotype:0000572:neuronal outgrowth variant |
| egg laying defective | "Eggs are not laid, laid at a slower rate or eggs are laid at a later stage of development compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPaper00025054] |
WBPhenotype:0000640:egg laying variant |
| egg laying variant | " Animals exhibit variations in the stage of eggs laid, egg laying cycle, number of eggs or egg laying in response to stimuli compared to control." [pmid:11813735, pmid:9697864, WB:cab] |
WBPhenotype:0000525:organism behavior variant |
| embryo osmotic integrity defective early emb | "Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing." [WB:cab, WB:cgc7141] |
WBPhenotype:0000041:osmotic integrity variant WBPhenotype:0001178:egg integrity defective early emb |
| embryo osmotic pressure sensitive early emb | "Embryos rupture when placed on a 2% agar pad and covered with a coverslip." [WB:cab, WB:cgc5599] |
WBPhenotype:0001178:egg integrity defective early emb |
| embryonic arrest | "Cessation of development during any stage occurring after fertilization and until hatching compared to control." [WB:WBPerson712] |
WBPhenotype:0000749:embryonic development variant |
| embryonic lethal | "Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054] |
WBPhenotype:0000062:lethal WBPhenotype:0000749:embryonic development variant |
| enzyme activity reduced | "Any variation that results in a decrease in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000727:enzyme activity variant |
| epithelial cell morphology variant | "Any variation in the morphological appearance of epithelial cells compared to control animals." [WB:WBPerson557] |
WBPhenotype:0002108:cell type morphology variant |
| epithelial morphology variant | "Variations in the form, composition or structure of the layer of cells that cover the external surface of an organism and form the inner lining between the tissues and organs of that organism and the external environment compared to control. In C. elegans epithelial cells include epithelium of the alimentary tract, intestinal cells, hypodermis, interfacial cells and somatic gonad cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000600:epithelial system morphology variant |
| everted vulva | "The eversion process, in which the vulval invagination is turned inside out during the final molt, is disrupted. In C.elegans, such variations in vulval eversion are primarily due to developmental defects in the somatic gonad (and sometimes vulva)." [WB:cab, WB:WBPaper00001738, WB:WBPerson2021, WB:WBPerson261] |
WBPhenotype:0000695:vulva morphology variant |
| excess maternal pronucleus early emb | "One-cell embryos have two or more maternal pronuclei." [WB:cab, WB:cgc5599] |
WBPhenotype:0001164:excess pronucleus early emb |
| exploded through vulva | "The animal is ruptured at the vulva and displays an extrusion of internal organs at the site of rupture." [WB:WBPaper00027633, WB:WBPaper00031094, WB:WBPerson712] |
WBPhenotype:0000619:epithelial system development variant |
| extended life span | "The duration of viability in the adult phase of the life-cycle surpasses that of control animals." [GO:0008340, WB:WBPerson712] |
WBPhenotype:0000039:life span variant |
| fat content reduced | "Animals exhibit less fat or lipid than observed in control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712] |
WBPhenotype:0001182:fat content variant |
| feeding inefficient | "Animals are unable to ingest nutrients at a rate similar to control animals." [WB:WBPaper00032342, WB:WBPerson712] |
WBPhenotype:0000659:feeding behavior variant |
| fewer seam cells | "The population of the lateral, alae-producing epithelial cells (seam cells) is reduced compared to control animals." [WB:WBPaper00034768] |
WBPhenotype:0000701:epithelial development variant WBPhenotype:0002174:cell number decreased |
| foraging behavior variant | "Variations in the behavior by which an organism locates food compared to control animals. In C. elegans roaming or dwelling activity on food are two examples of parameters used to assess this behavior. Roaming is defined as moving in a high-speed forward direction with brief backward movement, often traversing wide regions. Dwelling is defined as low-speed/high turning movement restricted to a confined region." [GO:0060756, WB:WBPaper00005621, WB:WBPaper00031455, WB:WBPerson712] |
WBPhenotype:0000525:organism behavior variant |
| forward locomotion decreased | "Animals spend less time in forward locomotion, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0002345:forward locomotion variant |
| forward point velocity decreased | "Animals exhibit decreased velocity of forward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0001716:forward point velocity variant |
| frequency body bend reduced | "Animals exhibit a reduction in the frequency of oscillations between adjacent body segments from that observed for control animals." [WB:WBPaper00024949, WB:WBPerson557, WB:WBPerson712] |
WBPhenotype:0001213:locomotion reduced WBPhenotype:0004023:frequency of body bend variant |
| gastrulation variant | "Variations in the process by which the germ layers become positioned in an embryo compared to control animals. Gastrulation involves the proper ingression of small groups of cells at various times into the blastocoel space." [WB:WBPaper00027251, WB:WBPerson2021] |
WBPhenotype:0000749:embryonic development variant |
| germ cell compartment anucleate | "Germ cell compartments do not contain a nucleus." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001970:germ cell compartment nuclei number variant |
| germ cell compartment expansion absent | "The compartments of the germline do not increase in size." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001980:germ cell compartment expansion variant |
| germ cell compartment expansion variant | "Animals exhibit variations in the increase in size of compartments of the germline. In the C. elegans germline, syncytial compartments enlarge just prior to and coincident with the loop region, eventually abscising, to become fully enclosed germ cells (oocytes)." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001969:germ cell compartment morphology variant |
| germ cell compartment large | "Germ cell compartments are larger than that of control animals." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001973:germ cell compartment size variant |
| germ cell compartment morphology variant | "Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis). These compartments eventually undergo cellularization and become oocytes." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0000900:germ cell morphology variant |
| germ cell compartment multinucleate | "Germ cell compartments contain multiple nuclei." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001970:germ cell compartment nuclei number variant |
| germ cell compartment size variant | "Any variation in germ cell compartment size compared to control." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001969:germ cell compartment morphology variant |
| germ cell partition absent | "Animals lack germ cell partitions (germ cell compartments)." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001977:germ cell partition morphology variant |
| germ cell partition morphology variant | "Any variation in the form or composition of the compartment partitions in the germline of females/hermaphrodites that exist when nuclei are still connected to a common cytoplasm (rachis), compared to control animals. " [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001969:germ cell compartment morphology variant |
| germline nuclear positioning variant | "Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0000511:nuclear positioning variant |
| glycogen levels variant | "Any variation in the levels of the polymerized form of glucose throughout the body of the animal as compared to controls." [WB:WBPaper00033086, WB:WBPerson2987] |
WBPhenotype:0000027:organism metabolism processing variant |
| gonad degenerate | "Animals contain a gonad that initially functioned, but subsequently stopped. In hermaphrodites or females there is often the presence old embryos and/or hatched larva, but no young embryos, in the uterus." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001355:gonad morphology variant |
| gonad development variant | "Variations in the progression of the organ that produces gametes over time, from its formation to the mature structure compared to control." [GO:0008406, WB:WBPerson2021] |
WBPhenotype:0000624:reproductive system development variant |
| gonad migration variant | "Variations in the gross movement of the whole structure of the gonad along the body wall, behind the gonadal leader cell and away from the developing vulva compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000624:reproductive system development variant |
| gonad morphology variant | "Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000605:reproductive system morphology variant |
| gonad small | "A decrease in size of the specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas)." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001355:gonad morphology variant |
| gonad vesiculated | "Animals contain small, fluid-filled, anucleate, spherical membrane-bound structures within the gonad." [GO:0031982, WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001355:gonad morphology variant |
| growth rate variant | "The increase in size or mass of an organism over time during the lifespan of the organism or over any developmental stage(s) is not similar to that observed for control animals." [GO:0040007, WB:WBPerson712] |
WBPhenotype:0000030:growth variant |
| growth variant | "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) compared to control animals." [GO:0040007, WB:WBPerson2021] |
WBPhenotype:0000577:organism homeostasis metabolism variant |
| gut granule development variant | "Any variation in the progression of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes over time compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000705:intestinal cell development variant |
| head bend angle variant | "Any variation in the extent of the maximum flex of the most anterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0001265:head movement variant |
| head morphology variant | "Animals exhibit variations in the form, structure or composition of any portion of their anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring) compared to control." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000582:organism segment morphology variant |
| heparan sulfate biosynthesis variant | "Animals exhibit variations in the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan compared to control." [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712] |
WBPhenotype:0001696:biosynthesis variant |
| hermaphrodite fertility reduced | "Hermaphrodites exhibit a reduction in the production of new individuals owing to defects in gamete competence and/or function compared to control animals." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000806:hermaphrodite fertility variant |
| hermaphrodite self sterile | "Hermaphrodites fail to produce any viable progeny via self-fertilization. However, such hermaphrodites can successfully reproduce if mated to control males." [WB:WBPaper00001075, WB:WBPerson2021] |
WBPhenotype:0000694:hermaphrodite sterile |
| hermaphrodite sterile | "Hermaphrodites fail to generate viable self-progeny and/or cross-progeny." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000688:sterile WBPhenotype:0001259:hermaphrodite fertility reduced |
| high incidence male progeny | "Higher numbers of male progeny occur in the population compared to control populations. In C. elegans, the high incidence of males phenotype in a self-fertilizing hermaphrodite population is a result of an increase in X chromosome nondisjunction." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPerson712] |
WBPhenotype:0001664:X chromosome nondisjunction |
| HSN migration variant | "Any variation in the normal anterior movement of the HSN motor neurons from their birthplace in the tail to positions near the middle of the embryo compared to control animals." [WB:WBPaper00001836, WB:WBPerson2021] |
WBPhenotype:0001229:anterior neuron migration defective |
| hypodermal cell elongation defective | "During epidermal morphogenesis, hypodermal cells do not properly undergo the characteristic cell shape changes necessary for the embryo to elongate." [WB:WBPaper00003991, WB:WBPerson712] |
WBPhenotype:0000701:epithelial development variant |
| hypodermis disorganized | "Hypodermal cells fail to be organized in the same manner as observed in control animals. In C. elegans, hypodermal cells typically organize into distinct dorsal, lateral and ventral rows and cover the entire body." [WB:WBPaper00027006, WB:WBPerson2021] |
WBPhenotype:0000703:epithelial morphology variant |
| intestinal fluorescence increased | "Animals exhibit an increase in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine." [WB:WBPerson557] |
WBPhenotype:0000293:alimentary system pigmentation variant |
| intestinal morphology variant | "Animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000598:alimentary system morphology variant |
| L1 lethal | "Animals die at the L1 stage of the life cycle." [WB:WBPerson2021] |
WBPhenotype:0000057:early larval lethal |
| larval arrest | "The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021] |
WBPhenotype:0000750:larval development variant WBPhenotype:0001016:larval growth variant |
| larval lethal | "The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712] |
WBPhenotype:0000062:lethal |
| late embryonic arrest | "Cessation of development during the final stages of embryogenesis. In C. elegans, this stage normally occurs 620-800 min after the first cleavage at 20C and is the stage after elongation." [WB:WBPerson101] |
WBPhenotype:0000867:embryonic arrest |
| lethal | "Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021] |
WBPhenotype:0000531:organism development variant |
| life span variant | "Adult life span is either longer or shorter than typical of control animals." [GO:0008340, WB:cab, WB:WBPaper00005863, WB:WBPaper00026717, WB:WBPerson557] |
WBPhenotype:0000576:organism physiology variant |
| locomotion variant | "Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712] |
WBPhenotype:0001206:movement variant |
| long | "Animals are longer than control animals at the same developmental stage." [WB:cab, WB:cgc31] |
WBPhenotype:0001726:body length variant |
| lumpy | "Animals have protrusions or bumps on their exterior which are not characteristic of control animals." [WB:WBPerson557] |
WBPhenotype:0000535:organism morphology variant |
| lysosome-related organelle morphology variant | "Any variation in the form or composition of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] |
WBPhenotype:0002089:cell component morphology variant |
| maternal sterile | " Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557] |
WBPhenotype:0000694:hermaphrodite sterile |
| meiotic chromosome segregation variant | "Variations in the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle, compared to control." [GO:0045132, WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000773:chromosome segregation variant |
| membrane trafficking variant | "Any variation in the directed movement of substances in a cell, from one side of a membrane to another, compared to control." [GO:0005215, WB:WBPaper00025137, WB:WBPerson2021] |
WBPhenotype:0000536:cell physiology variant |
| metabolic pathway variant | "Animals exhibit variations in processes that are responsible for chemical changes compared to control animals. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GO:0008152, WB:WBPerson712] |
WBPhenotype:0000027:organism metabolism processing variant |
| mid larval lethal | "Animals die in between the early and late larval stages. In C. elegans, this occurs during the L2- L3 larval stages of the life cycle." [WB:WBPerson2021] |
WBPhenotype:0000054:larval lethal |
| molt defect | "Animals exhibit defects in the process of periodic shedding, of part or all of its cuticle, during cuticle replacement that punctuates each larval stage." [GO:0018996, WB:WBPerson712] |
WBPhenotype:0002041:molt variant |
| molt variant | "Animals exhibit variation in timing or ability to molt." [WB:WBPaper00040467, WB:WBPerson712] |
WBPhenotype:0000750:larval development variant |
| mRNA levels increased | "Animals exhibit elevated levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021] |
WBPhenotype:0000114:mRNA expression variant |
| mRNA levels reduced | "Animals exhibit decreased levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021] |
WBPhenotype:0000114:mRNA expression variant |
| mRNA surveillance defective | "Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. In C. elegans, mutations in such loci often act as allele-specific non gene-specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis of male and hermaphrodite genitalia." [WB:WBPaper00001192, WB:WBPaper00004926] |
WBPhenotype:0000028:RNA processing variant |
| multiple cytoplasmic cavities early emb | "Multiple vesicles, vacuoles, or cavities are seen during early embryogenesis." [cgc:5599, WB:cab] |
WBPhenotype:0001081:cytoplasmic morphology defective early emb |
| multiple nuclei early emb | "Embryos contain more than one nucleus per cell in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] |
WBPhenotype:0000746:cell division variant WBPhenotype:0001142:nuclear number defective early emb WBPhenotype:0001894:nuclear number variant |
| multiple nuclei oocyte | "Haploid female germ cells (oocytes) contain more than one nucleus." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0000186:oogenesis variant WBPhenotype:0001260:oocyte morphology variant WBPhenotype:0001894:nuclear number variant |
| nervous system morphology variant | "Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals." [WB:WBPerson712] |
WBPhenotype:0000534:organ system morphology variant |
| neuron cell body absent misplaced | "The body of a neuron is not where it should be when compared to control animals; it is absent or misplaced." [WB:WBPaper00000502, WB:WBPaper00000635, WB:WBPerson712] |
WBPhenotype:0000816:neuron development variant |
| neuron morphology variant | "Animals display variations in the structure or organization of components of the neuronal cell internal to the cell itself or in relation to the cellular environment compared to control. A neuron is a major cell type of nervous tissue specialized for transmission of information in the form of patterns of impulses." [WB:cab, WB:WBPerson712] |
WBPhenotype:0000604:nervous system morphology variant WBPhenotype:0002108:cell type morphology variant |
| nicotine hypersensitive | "Animals respond to nicotine at lower concentrations or shorter exposure compared to control. Nicotine is a cholinergic agonist." [WB:cab, WB:cgc7388, WB:WBPerson557] |
WBPhenotype:0001573:nicotine response variant WBPhenotype:0001579:cholinergic agonist hypersensitive |
| no oocytes | "Hermaphrodites lack fully specialized female gametes that are competent for fertilization." [WB:WBPerson2021] |
WBPhenotype:0000395:no differentiated gametes |
| nonsense mRNA accumulation | "Animals exhibit a decrease in the regulated breakdown of mRNA transcripts in which an amino-acid codon has changed to a premature stop codon and the 3 prime end is not protected by a poly(A) tail." [GO:0070478, WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000027:organism metabolism processing variant |
| nose movement increased | "Animals exhibit an increase in the movement of the extreme anterior portion of the body to a new location compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0002301:nose movement variant |
| nuclear appearance variant | "The morphological appearance of nuclei differs from control animals." [WB:cab] |
WBPhenotype:0002089:cell component morphology variant |
| nuclear fallout | "Nuclei have fallen out of developing germ cell compartments into the rachis." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001952:germline nuclear positioning variant |
| nuclei small | "Nuclei of specific cells are smaller compared to control animals." [WB:WBPerson557] |
WBPhenotype:0001028:nuclear appearance variant |
| one cell arrest early emb | "Embryos fail to divide and arrest as one-cell embryos." [WB:cab, WB:cgc5599] |
WBPhenotype:0001100:early embryonic lethal |
| oocyte accumulation | "An increased number of oocytes are retained in the gonad without becoming endomitotic, compared to control. " [WB:WBPaper00006281, WB:WBPaper00030855] |
WBPhenotype:0001260:oocyte morphology variant |
| oocyte morphology variant | "Haploid female germ cells (oocytes) exhibit variations in their overall structure, appearance or contents compared to control." [WB:WBPaper00001883, WB:WBPerson2021] |
WBPhenotype:0000900:germ cell morphology variant |
| oocyte number decreased | "A decreased number of celullarized haploid female germ cells (oocytes) are present in the gonad compared to control." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0000186:oogenesis variant WBPhenotype:0001260:oocyte morphology variant |
| oocyte septum formation variant | "Animals exhibit variations in the partitioning of oocytes from each other compared to control animals." [WB:WBPaper00028947] |
WBPhenotype:0000399:somatic gonad development variant |
| oocytes lack nucleus | "Haploid female germ cells (oocytes) lack a nucleus." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0000186:oogenesis variant WBPhenotype:0001260:oocyte morphology variant |
| oocytes small | "The size of haploid female germ cells (oocytes) are significantly smaller compared to control." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001260:oocyte morphology variant |
| oogenesis variant | "Any aberrancy in the processes that influence the generation and maturation of oocytes compared to control animals." [GO:0048477, WB:WBPerson2021] |
WBPhenotype:0000894:germ cell differentiation variant |
| organism development variant | "Any variation in the progression of a worm at any time from its fertilization to adulthood compared to control." [WB:cab] |
WBPhenotype:0000518:development variant |
| organism heat hypersensitive | "Animals respond to heat at a lower temperature or a shorter exposure time compared to control animals." [WB:WBPerson557] |
WBPhenotype:0001273:organism heat response variant |
| organism high sodium chloride hypersensitive | "Animals respond to sodium chloride at a lower concentration or a shorter exposure compared to control animals. In C. elegans, this is often assayed through generation time and progeny number." [pmid:16027367, WB:cab] |
WBPhenotype:0000876:organism osmotic stress response variant |
| organism homeostasis metabolism variant | "Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the organism compared to control." [GO:0048871, WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000576:organism physiology variant |
| organism hypersensitive desication | "Animals respond to less severe drought-like conditions or a shorter exposure compared to control animals." [WB:WBPerson2021] |
WBPhenotype:0001417:organism desication response variant |
| organism metabolism processing variant | "Variations in the chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances compared to control." [GO:0008152, WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000577:organism homeostasis metabolism variant |
| organism morphology variant | "Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395] |
WBPhenotype:0000520:morphology variant |
| organism oxidative stress resistant | "Animals fail to respond to the levels of reactive oxygen species that elicit a response in control animals." [WB:WBPerson2021] |
WBPhenotype:0001620:organism oxidative stress response variant |
| organism pathogen response variant | "Animals exhibit variations in their response to disease causing agents, compared to control. Pathogen response includes prevention, damage control and recovery from the infection caused by the attack." [GO:0006952, WB:WBPaper00032196, WB:WBPerson2021, WB:WBPerson712] |
WBPhenotype:0000738:organism environmental stimulus response variant |
| organism stress response variant | "Animals exhibit variations in response to stress stimuli compared to control animals." [GO:0006950, WB:WBPerson712] |
WBPhenotype:0000738:organism environmental stimulus response variant |
| organism toxic chemical response variant | "Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals." [WB:WBPerson557] |
WBPhenotype:0000523:chemical response variant |
| pachytene progression during oogenesis variant | "Developing oocytes show defects in their entry, progression through or exit from the pachytene stage compared to control animals. Pachytene is a cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GO:0000239, WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001824:meiotic progression prophase variant |
| pachytene region organization variant | "Animals exhibit variations from control animals in the organization of the germ cell nuclei in the pachytene stage region of the gonad. In C. elegans the pachytene region begins just proximal to the germline's transition zone, where germ cells coordinately switch into the leptotene/zygotene stage from the premeiosis stage (WormAtlas)." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001355:gonad morphology variant WBPhenotype:0001946:pachytene progression during oogenesis variant |
| pale | "Animals show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000527:organism pigmentation variant |
| paralyzed | "Animals do not move and are not responsive to external mechanical stimulation." [WB:cab] |
WBPhenotype:0001213:locomotion reduced |
| paralyzed arrested elongation two fold | "Movement and elongation ceases at the two-fold stage. The myofilament lattice in body wall muscle cells is variant. However, development in embryos continues. Embryos hatch as inviable larvae." [WB:cab, WB:cgc1894] |
WBPhenotype:0000050:embryonic lethal WBPhenotype:0000494:two fold arrest |
| paraquat hypersensitive | "Animals respond to paraquat at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] |
WBPhenotype:0000460:paraquat response variant |
| paraquat resistant | "Animals fail to respond to the concentration of paraquat that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] |
WBPhenotype:0000460:paraquat response variant |
| patchy coloration | "Animals exhibit an uneven distribution of biochromes or any other substances that cause disparate transparency/translucency compared to control animals." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000527:organism pigmentation variant |
| path curvature increased | "Animals exhibit increases in the extent to which the overall path of movement is curved, producing tighter and more frequent curves compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0002335:path curvature variant |
| pathogen adherence defect | "Pathogens are unable to adhere/colonize the surface of host animals. This defect is often associated with changes in cuticle surface properties of the host." [WB:WBPaper00028877, WB:WBPerson2021] |
WBPhenotype:0001014:pathogen resistance increased WBPhenotype:0001415:pathogen adherence variant |
| pathogen induced death increased | "Animals are more prone to lethality as a result of infection compared to control." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0001013:pathogen susceptibility increased |
| pathogen resistance increased | "Animals are less prone to infection compared to control." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0001012:organism pathogen response variant |
| pattern of transgene expression variant | "Any variation in the cellular or subcellular pattern of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] |
WBPhenotype:0000306:transgene expression variant |
| pausing variant | "Animals exhibit variations in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0001213:locomotion reduced |
| pesticide response variant | "Animals exhibit variations in their response to any chemical substance that is used for killing pests, compared to that observed in control animals." [WB:WBPerson557] |
WBPhenotype:0000738:organism environmental stimulus response variant |
| pharyngeal development variant | "Variations in the progression of the pharynx (feeding organ) over time, from its formation to the mature structure compared to control. In C. elegans the pharynx is divided into the anterior and posterior regions. The anterior region includes the corpus (procorpus and metacorpus - first bulb) and the posterior region includes the isthmus and terminal bulb (second bulb)." [GO:0043282, WB:WBPerson2021] |
WBPhenotype:0000617:alimentary system development variant |
| pharyngeal pumping rate variant | "The number of coordinated contraction-relaxation cycles (pumps) exhibited by the pharyngeal muscle deviates from that observed for control animals." [WB:WBPaper00001709, WB:WBPerson712] |
WBPhenotype:0000634:pharyngeal pumping variant |
| pharyngeal pumping reduced | "Pharyngeal pumping motion occurs at a slower rate than control animals." [WB:WBPaper00001709] |
WBPhenotype:0001006:pharyngeal pumping rate variant |
| pharynx unattached | "The pharynx or pharyngeal muscle does not form a functional connection to the mouth or buccal cavity." [WB:WBPaper00031910, WB:WBPerson712] |
WBPhenotype:0000707:pharyngeal development variant |
| pheromone induced dauer formation defective | "Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000013:dauer defective WBPhenotype:0000132:pheromone induced dauer formation variant |
| polar body extrusion defective early emb | "Unextruded or resorbed polar body(ies) leading to an extra PNs in P0 and/or extra karyomeres in AB/P1." [WB:cab, WB:cgc7141] |
WBPhenotype:0000775:meiosis variant WBPhenotype:0001147:polar body defective early emb |
| pore forming toxin hypersensitive | "Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0000010:drug hypersensitive WBPhenotype:0002058:pore forming toxin response variant |
| pore forming toxin resistant | "Animals fail to respond to the concentration of pore forming toxins that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0000011:drug resistant WBPhenotype:0002058:pore forming toxin response variant |
| post hermaphrodite contact variant | "Males exhibit variations in mating behavior after contacting its mate compared to control." [WB:WBPerson557] |
WBPhenotype:0000648:male mating variant |
| presynaptic region morphology variant | "Animals display variations in the structure, configuration, distribution or ratio of the components of the vesicle-filled varicosities of the synapse compared to control." [GO:0042734, WB:WBPaper00000938, WB:WBPaper00027305, WB:WBPaper00028886, WB:WBPerson712] |
WBPhenotype:0000616:synapse morphology variant |
| pronucleus centrosomes defective early emb | "Pronucleus is abnormal in the inviable embryo." [WB:cab, WB:WBPerson1815] |
WBPhenotype:0001034:pronuclear nuclear appearance defective early emb |
| protein aggregation variant | "Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021] |
WBPhenotype:0001370:protein protein interaction variant |
| protein expression reduced | "Any change that results in lower than normal levels of protein expression compared to control animals." [WB:kmva] |
WBPhenotype:0001400:level of protein expression variant |
| protein modification variant | "Variations in the covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications), compared to control. This includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GO:0006464, WB:WBPerson2021] |
WBPhenotype:0000112:protein expression variant |
| protein phosphorylation increased | "Animals exhibit higher levels of protein phosphorylation compared to that observed in control animals." [WB:WBPerson2021] |
WBPhenotype:0001349:protein phosphorylation variant |
| protein subcellular localization variant | "Any variation in the placement of a protein within in a cell or cellular compartment compared to control." [WB:WBPerson557] |
WBPhenotype:0001408:pattern protein expression variant |
| protruding vulva | "Animals undergo incomplete vulval morphogenesis, resulting in the formation of a single protrusion at the site of the vulva." [WB:WBPaper00004408, WB:WBPerson2021] |
WBPhenotype:0000695:vulva morphology variant |
| pseudocleavage defective early emb | "Pseudocleavage is atypical in the inviable one-cell embryo." [WB:cab, WB:WBPerson1815] |
WBPhenotype:0001100:early embryonic lethal |
| Q neuroblast lineage migration variant | "The daughters of the Q neuroblasts exhibit variation in their characteristic movements compared to control animals." [WB:WBPaper00001954, WB:WBPaper00031356, WB:WBPerson712] |
WBPhenotype:0001140:neuron migration variant |
| RAB-11 recycling endosome localization variant | "Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987] |
WBPhenotype:0002104:recycling endosome localization variant |
| RAB-11 recycling endosome morphology variant | "Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987] |
WBPhenotype:0002093:recycling endosome morphology variant |
| rachis absent | "The nucleus-free core of germline cytoplasm in the gonad is missing." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001940:rachis morphology variant |
| rachis morphology variant | "Any variation in the form, structure or composition of the nucleus-free core of germ line cytoplasm in the gonad compared to control animals. In the C. elegans germline, nuclei exiting mitosis and entering meiosis are arranged along the cortex of the germline, partially enclosed by cellular membrane, forming a nucleus-free core of germline cytoplasm, called the rachis." [WB:WBPaper00031889, WB:WBPerson557] |
WBPhenotype:0001355:gonad morphology variant |
| rachis narrow | "The nucleus-free core of germline cytoplasm in the gonad is not as wide as control animals." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001940:rachis morphology variant |
| rachis wide | "The width of the nucleus-free core of germline cytoplasm in the gonad is larger compared to control animals." [WB:WBPaper00038381, WB:WBPerson557] |
WBPhenotype:0001940:rachis morphology variant |
| receptor mediated endocytosis defective | "Animals exhibit defects in the cell-mediated uptake of external materials via receptor activity. Receptor-mediated endocytosis ensures specificity of transport and generally occurs via clathrin-coated pits and vesicles. In C. elegans, this is often judged by the lack of yolk uptake in oocytes." [GO:0006898, pmid:16042554, WB:cab, WB:WBPerson2021] |
WBPhenotype:0001422:endocytic transport defect WBPhenotype:0001424:oocyte physiology variant |
| reduced brood size | "The characteristic number of offspring produced is lower compared to that of control animals." [WB:WBPerson557] |
WBPhenotype:0000673:brood size variant |
| roaming reduced | "Animals exhibit a decrease in their high-speed movement in the forward direction with brief backward movement compared to control. In C. elegans, Animals do not move more than a few body lengths from their starting position and searches occur locally with pivoting behavior." [WB:WBPaper00003743, WB:WBPaper00031455, WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson712] |
WBPhenotype:0000238:foraging reduced WBPhenotype:0001213:locomotion reduced WBPhenotype:0002315:roaming variant |
| seam cell fusion variant | "Variations in the ability of seam cells to fuse to form a continuous syncytium along the body wall late larval development, (separate from the hyp 7 syncytium), compared to control (WormAtlas). Hypodermal seam cells lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, and are required for alae formation." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000165:cell fusion variant |
| short | "Animals exhibit a decreased body length compared to control animals of the same developmental stage." [WB:WBPerson712] |
WBPhenotype:0001726:body length variant |
| shortened life span | "The duration of viability in the adult phase of the life-cycle is less than that of control animals." [GO:0008340, WB:WBPerson712] |
WBPhenotype:0000039:life span variant |
| sick | "Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712] |
WBPhenotype:0000030:growth variant |
| sister cell division timing asynchrony reduced | "Animals exhibit sister cells that have lost otherwise normal asynchrony of cell division timing, compared to control animals. This results in sister cells aberrantly dividing in synchrony." [WB:WBPaper00046953, WB:WBPerson2987] |
WBPhenotype:0000746:cell division variant |
| skiddy | "Apparently normal sinusoidal movement, but appear to have poor traction on the agar surface of a culture plate." [WB:cab, WB:WBPaper00026735] |
WBPhenotype:0001701:spastic locomotion |
| slow embryonic development | "The progression through stages between fertilization to hatching are temporally retarded." [WB:WBPerson712] |
WBPhenotype:0000674:slow development WBPhenotype:0000749:embryonic development variant |
| slow growth | "Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557] |
WBPhenotype:0000030:growth variant WBPhenotype:0000043:general pace of development variant WBPhenotype:0000438:retarded heterochronic variations |
| small | "Animals are shorter and thinner than control animals at the same developmental stage." [WB:cab, WB:cgc31] |
WBPhenotype:0001726:body length variant WBPhenotype:0001727:body width variant |
| spermatogenesis variant | "Any variation in the processes that influence the generation and maturation of spermatozoa (motile sperm) compared to control." [GO:0007283, WB:WBPaper00027300, WB:WBPerson2021] |
WBPhenotype:0000894:germ cell differentiation variant |
| squashed vulva | "The apparent partial collapse of the vulval invagination and the elongation of central vulva cells often leading to a flattened appearance." [WB:WBPaper00003405] |
WBPhenotype:0000510:vulval invagination variant L4 |
| sterile | "Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712] |
WBPhenotype:0001384:fertility reduced |
| sterile progeny | "Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557] |
WBPhenotype:0000069:progeny variant WBPhenotype:0000688:sterile |
| surface antigen negative | "Cuticles or cuticular extracts do not bind antibodies that are observed to bind the surfaces or cuticular extracts of Bristol N2 animals of the same developmental stage." [WB:WBPaper00001280, WB:WBPerson712] |
WBPhenotype:0001687:surface antigenicity variant |
| tail bend angle increased | "Animals exhibit an increase in the extent of the maximum flex of the most posterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0002288:tail bend angle variant |
| thin | "Animals exhibit a reduced girth compared to a control animal of the same developmental stage." [WB:WBPerson712] |
WBPhenotype:0001727:body width variant |
| transgene expression increased | "Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] |
WBPhenotype:0000962:level of transgene expression variant |
| transgene expression reduced | "Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] |
WBPhenotype:0000962:level of transgene expression variant |
| transgene expression variant | "Any variation in the characteristic expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to control animals." [WB:WBPerson557] |
WBPhenotype:0000717:gene expression variant |
| transgene subcellular localization variant | "Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] |
WBPhenotype:0000961:pattern of transgene expression variant |
| tunicamycin hypersensitive | "Animals respond to tunicamycin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00030877, WB:WBPerson557] |
WBPhenotype:0000359:tunicamycin response variant |
| turning frequency variant | "Animals exhibit variations in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal)." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557] |
WBPhenotype:0002311:turning variant |
| ventral closure defective | "The animal displays defects in any step of the ventral enclosure process resulting an embryo that is not enclosed and or with interior cells protruding out of the embryo." [WB:WBPaper00003991, WB:WBPerson712] |
WBPhenotype:0001566:ventral enclosure variant |
| ventral enclosure variant | "Any variation in the process that regulates the migration of ventral epidermal cells toward the ventral midline (to encase underlying cells in an epithelial monolayer) in developing embryos compared to control." [WB:WBPaper00027244, WB:WBPerson2021] |
WBPhenotype:0000749:embryonic development variant |
| ventral nerve cord development variant | "Variations in any process whose specific outcome is the development and/or maintenance of the ventral nerve cord." [WB:WBPerson557] |
WBPhenotype:0000945:neuropil development variant |
| vulva cell fate specification variant | "Any aberrancy in the processes that govern acquisition of vulval cell fates compared to control animals." [WB:WBPerson2021] |
WBPhenotype:0000699:vulva development variant WBPhenotype:0002017:VPC competence variant |
| vulva morphology variant | "Animals exhibit variations in the gross structure or organization of the reproductive organ required for depositing eggs and for influencing male mating behavior compared to control." [WB:WBPerson712] |
WBPhenotype:0001335:hermaphrodite reproductive system morphology variant |
| vulval invagination variant L4 | "The characteristic Christmas-tree shaped invagination formed by the terminal vulval cells at the mid-late L4 stage is altered." [WB:WBPaper00001738, WB:WBPerson2021] |
WBPhenotype:0000695:vulva morphology variant WBPhenotype:0000699:vulva development variant |