CGGDB

> expression > intestinal cell

Definition: "any of 20 large epithelial cells which form a tube and are mostly situated as bilaterally symmetric pairs around the tubular lumen. Each of these cell pairs forms an intestinal ring ( II-IX int rings). The most anterior intestinal ring (int ring I), however, is made of four cells. Intestinal cells contain large nuclei with large nucleoli and numerous autofluorescent granules in their cytoplasm." [WBPaper:00038216]

JCEG ID

Family

Name

Locus Tag

Human Ortholog Name

OMIM

GWAS Catalog

JCEG033 ^*

Fucosyltransferases

fut-2

EGAP9.2

FUT2

STREAM	RAF	p-value	OR	BETA	CI	Study
UPSTREAM		0.000002 (Conditioned on rs2303759)	1.08		[1.07-1.09]	21833088
	Sawcer S 2011-08-11 Nature Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
MAPPED		0.00000004	1.183432		[1.15-1.22]	25574825
	Baurecht H 2015-01-08 Am J Hum Genet Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
MAPPED		0.000000000000000000000000000000000004		70.21 (pg/ml increase)	[59.37-81.05]	22367966
	Lin X 2012-02-24 Hum Mol Genet Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
MAPPED		0.00000000000000000000000000000000000000000000000000000001				24941225
	Liang Y 2014-06-18 PLoS One Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
MAPPED	0.53	0.0000000000001 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)		0.045 (unit increase)	[0.033-0.057]	24816252
	Shin SY 2014-05-11 Nat Genet An atlas of genetic influences on human blood metabolites.
MAPPED	0.53	0.00000000000000000003 (vitamin B12)		49.77 (pg/ml increase)	[37.09-62.45]	19303062
	Tanaka T 2009-03-18 Am J Hum Genet Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
UPSTREAM	0.52	0.00000005 (Single Height-males)		0.07 (unit increase)	[0.043-0.097]	23449627
	Cousminer DL 2013-02-27 Hum Mol Genet Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
MAPPED	0.49	0.0000000002		1.27 (mg/dL increase)	[0.86-1.68]	20686565
	Teslovich TM 2010-08-05 Nature Biological, clinical and population relevance of 95 loci for blood lipids.
MAPPED	0.49	0.00000000000000005		0.09 (pg/ml decrease)	[0.07-0.11]	18776911
	Hazra A 2008-09-07 Nat Genet Common variants of FUT2 are associated with plasma vitamin B12 levels.
UPSTREAM	0.487	0.000000000007	1.07		[1.04-1.11]	21102463
	Franke A 2010-11-21 Nat Genet Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
MAPPED	0.483	0.000000000000001	1.107		[1.071-1.143]	23128233
	Jostins L 2012-11-01 Nature Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
MAPPED	0.482	0.0000002 (Vitamin B12)		0.143 (unit increase)	[NR]	25147783
	Keene KL 2014-08-06 Front Public Health Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
MAPPED	0.47	0.0000000008		2.3 (% increase)	[1.80-2.90]	22001757
	Chambers JC 2011-10-16 Nat Genet Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
MAPPED	0.47	0.0000000000000001		0.031 (unit increase)	[NR]	24097068
	Willer CJ 2013-10-06 Nat Genet Discovery and refinement of loci associated with lipid levels.
MAPPED	0.464	0.00000000000000000004 (SM-11 + 2 other traits)		0.129 (unit increase)	[NR]	21886157
	Suhre K 2011-08-31 Nature Human metabolic individuality in biomedical and pharmaceutical research.
MAPPED	0.46	(CA19-9)		0.444 (U/ml increase)	[0.41-0.48]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.46	(CEA)		0.238 (ng/ml increase)	[0.21-0.26]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.44	0.000000000000002 (Plasma Vitamin B12)		0.07 (unit decrease)	[0.050-0.090]	19744961
	Hazra A 2009-09-10 Hum Mol Genet Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
MAPPED	0.431	0.00000002				20570966
	McGovern DP 2010-06-22 Hum Mol Genet Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
MAPPED	0.43	0.000000006		0.04 (unit increase)	[0.026-0.054]	25028398
	Weiss FU 2014-07-15 Gut Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
MAPPED	0.43	0.00000000003 (ADpSGEGDFXAEGGGVR)		0.041 (unit increase)	[0.029-0.053]	24816252
	Shin SY 2014-05-11 Nat Genet An atlas of genetic influences on human blood metabolites.
MAPPED	0.43	0.000000000000001		1.8 (% increase)	[0.80-2.80]	22001757
	Chambers JC 2011-10-16 Nat Genet Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
MAPPED	0.43	0.00000000000000000002 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)		0.055 (unit decrease)	[0.043-0.067]	24816252
	Shin SY 2014-05-11 Nat Genet An atlas of genetic influences on human blood metabolites.
MAPPED	0.272	0.000002 (Vitamin B12 )		0.03 (pmol/L increase)	[NR]	23251661
	Comuzzie AG 2012-12-04 PLoS One Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

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