JCEG ID JCEG223
Name gly-8      WormBase    NCBI Gene
Human Ortholog

GGDB:GALNT11 

OMIM: 615130 615133

OrthoList :   GALNT8   GALNT15   GALNT18   WBSCR17   GALNT9  (Ensembl Compara)

GGDB Score E-val
GALNT11 314 2e-87
GALNT2 275 1e-75
GALNT4 271 2e-74
GALNT14 270 3e-74
GALNT12 269 8e-74
GALNT6 268 2e-73
GALNT1 266 4e-73
GALNT13 263 4e-72
GALNT3 260 4e-71
GALNT15 251 2e-68
GALNT7 245 9e-67
GALNT10 238 1e-64
GALNT9 236 7e-64
GALNT5 232 7e-63
GALNT19 226 5e-61
GALNT8 217 3e-58
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name ppGalNAcT
Locus Tag Y66A7A.6
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Hagen FK, Nehrke K J. Biol. Chem. (1998) 273 (14) :8268-77 [PMID : 9525933] cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans.

Schwientek T, Bennett EP, Flores C, Thacker J, Hollmann M, Reis CA, Behrens J, Mandel U, Keck B, Schafer MA, Haselmann K, Zubarev R, Roepstorff P, Burchell JM, Taylor-Papadimitriou J, Hollingsworth MA, Clausen H J. Biol. Chem. (2002) 277 (25) :22623-38 [PMID : 11925450] Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK Mol. Biol. Cell (2005) 16 (9) :4202-13 [PMID : 15987734] The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Bennett EP, Mandel U, Clausen H, Gerken TA, Fritz TA, Tabak LA Glycobiology (2012) 22 (6) :736-56 [PMID : 22183981] Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.

WormBase (WS254)

Functional Descriptions gly-8

gly-8 encodes a predicted transmembrane polypeptide N-acetylgalactosaminyl transferase (ppGaNTase) similar to the essential Drosophila ppGaNTase encoded by Pgant35A; by homology, GLY-8 is predicted to function as a Golgi enzyme that catalyzes transfer of N-acetylgalactosamine to serine and threonine-containing acceptor peptides, thus initiating mucin-type O-glycosylation; as loss of gly-8 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLY-8 in C. elegans development and/or behavior is not yet known.
Deletion Mutants tm1156
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0005733

hypodermis "epidermal layer" [WB:pws] Enriched WBPaper00037950 : hypodermis_embryo_SelectivelyEnriched, hypodermis_embryo_enriched
WBPaper00037950
WB WBbt:0005757

male-specific "cells or anatomical parts specific to the male sex" [WB:rynl] Enriched WBPaper00026629 : L2_male_enriched
WBPaper00026629
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00026980 : intestine_enriched
WBPaper00026980 WormAtlas
WB WBbt:0008406

cephalic sheath cell "sheath cell of the cephalic sensilla." [WB:rynl] Enriched WBPaper00037950 : CEP-sheath-cells_adult_SelectivelyEnriched, CEP-sheath-cells_adult_enriched
WBPaper00037950

WBGene00001633
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele


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