JCEG ID | JCEG223 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Name | gly-8 WormBase NCBI Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||
Human Ortholog |
GGDB:GALNT11 OrthoList : GALNT8 GALNT15 GALNT18 WBSCR17 GALNT9 (Ensembl Compara)
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Family Name | ppGalNAcT | |||||||||||||||||||||||||||||||||||||||||||||||||||
Locus Tag | Y66A7A.6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
RNAi phenotype |
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Sequence Features | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Sequence | CDS |
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Protein |
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References |
Hagen FK, Nehrke K J. Biol. Chem. (1998) 273 (14) :8268-77 [PMID : 9525933] cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans. Schwientek T, Bennett EP, Flores C, Thacker J, Hollmann M, Reis CA, Behrens J, Mandel U, Keck B, Schafer MA, Haselmann K, Zubarev R, Roepstorff P, Burchell JM, Taylor-Papadimitriou J, Hollingsworth MA, Clausen H J. Biol. Chem. (2002) 277 (25) :22623-38 [PMID : 11925450] Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK Mol. Biol. Cell (2005) 16 (9) :4202-13 [PMID : 15987734] The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation. Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. Bennett EP, Mandel U, Clausen H, Gerken TA, Fritz TA, Tabak LA Glycobiology (2012) 22 (6) :736-56 [PMID : 22183981] Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family. |
Functional Descriptions |
gly-8 gly-8 encodes a predicted transmembrane polypeptide N-acetylgalactosaminyl transferase (ppGaNTase) similar to the essential Drosophila ppGaNTase encoded by Pgant35A; by homology, GLY-8 is predicted to function as a Golgi enzyme that catalyzes transfer of N-acetylgalactosamine to serine and threonine-containing acceptor peptides, thus initiating mucin-type O-glycosylation; as loss of gly-8 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLY-8 in C. elegans development and/or behavior is not yet known. |
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Deletion Mutants | tm1156 | |||||||||||||||||||||||||||||||||||||||||
In Situ | In Situ | |||||||||||||||||||||||||||||||||||||||||
Expression |
Expression
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WBGene00001633 Phenotype Homology_paralog |
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Phenotype | Definition | RNAi / Allele |