JCEG ID JCEG217
Name gly-3      WormBase    NCBI Gene
Human Ortholog

GGDB:GALNT1 

OMIM: 602273 608369

OrthoList :   GALNT1   GALNT13  (Ensembl Compara)

GGDB Score E-val
GALNT1 581 e-167
GALNT13 575 e-166
GALNT2 420 e-119
GALNT4 409 e-115
GALNT12 387 e-109
GALNT5 387 e-109
GALNT3 384 e-108
GALNT6 383 e-108
GALNT10 379 e-107
GALNT14 372 e-104
GALNT11 361 e-101
GALNT7 346 6e-97
GALNT9 321 2e-89
GALNT19 318 2e-88
GALNT15 291 3e-80
GALNT8 286 6e-79
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name ppGalNAcT
Locus Tag ZK688.8
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Hagen FK, Nehrke K J. Biol. Chem. (1998) 273 (14) :8268-77 [PMID : 9525933] cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans.

Schwientek T, Bennett EP, Flores C, Thacker J, Hollmann M, Reis CA, Behrens J, Mandel U, Keck B, Schafer MA, Haselmann K, Zubarev R, Roepstorff P, Burchell JM, Taylor-Papadimitriou J, Hollingsworth MA, Clausen H J. Biol. Chem. (2002) 277 (25) :22623-38 [PMID : 11925450] Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK Mol. Biol. Cell (2005) 16 (9) :4202-13 [PMID : 15987734] The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Bennett EP, Mandel U, Clausen H, Gerken TA, Fritz TA, Tabak LA Glycobiology (2012) 22 (6) :736-56 [PMID : 22183981] Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.

WormBase (WS254)

Functional Descriptions gly-3

gly-3 encodes an N-acetylgalactosaminyltransferase that is functional in vitro.
Deletion Mutants gk353
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0005753

seam cell "a group of hypodermal cells that lie along the apical midline of the hypodermis, at the extreme left and right sides between nose and tail" [WB:rynl, WBPaper:00038216] Certain WB:Expr7246 WBPaper00006525 WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00030839 : Embryo_Pan_Neuronal
WBPaper00030839 WormAtlas
WB WBbt:0005733

hypodermis "epidermal layer" [WB:pws] Certain WB:Expr7246 WBPaper00006525
WB WBbt:0005747

reproductive system Certain WB:Expr7246 WBPaper00006525
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Certain WB:Expr7246 WBPaper00006525 WormAtlas
WB WBbt:0005799

rectal gland cell Certain WB:Expr7246 WBPaper00006525 WormAtlas
WB WBbt:0006748

vulva "female genital." [WB:rynl] Certain WB:Expr7246 WBPaper00006525 WormAtlas

WBGene00001628
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele


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