JCEG ID |
JCEG194 |
Name |
gly-19
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:GCNT3
OMIM:
OrthoList :
GCNT7
GCNT4
GCNT2
GCNT3
GCNT1
GCNT6
(Ensembl Compara)
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
b6GnT |
Locus Tag |
F22D6.12
|
RNAi phenotype |
phenotype
|
WT
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
kr:Detected
tm:Detected
dxd:GVD/DEG
gg_motif:M1, M2, M3, M4, M5
|
Sequence |
CDS
atggttcgattcaaattcaaaacctcgttaattattgctatatttttttt gttcatatatttttctgtggaatcattgtttccaagaaaacaagaagaca aaaatgtgtcaaaacaatttttgaagtcgatttgtacaactgcttcagat tcatatttgttggataatatggagattaattgttcgaacattctcaaagg atataaaactaacgaaaaattggatatcatgcatttggatataattgaag aacaacttttttcttgtactaataaatgtcaaacgctgaaaactttattt cgattcaatacaaatccaatgtcagcagaagaaaaacattttccactatc ctatggaatgcttgtgtacaaggatttgccacaggttctttttcttctct catcaatctatcatcctcaaaacgagtactgtattgcggttggtgaaaat tctgctcccatatttcaaaacttactcagagaagtctcaacttgtttttc aaatgtacattttatgaaacgtccaccaataagttggggaagtcatgaaa taattgattcggtgtacgattgtctggaatttctgagtcacttggaaact gattggagatattttcaatacttatcaggagttgatattccattaaagac aaatctcgaaatggttcaaatattgaaacatctaaatggaacatcaaatg tcgaaattacaaattatcaacaagcacgactcaccggaaagaatgaaaat gaatctccacttccacttttcaaatcctcactatctgcaatcattccaag aaaagctgccaatcagctggcatcctccaatacagctcgaaagcttttag aatttctttggaatactgaaattgcagacgaaggattttggggtacttta tttggaaataaggaccaatttaatatttctggatcaataaactcaaaaga ttggatggaatatagagataatcaaaataatatttttaatccaacagatg gatggagttattacatatcaagagatcaaatttgggatccagaactttgt aaaaattacatgaaggatgattcatgtgtttttggaattggagatgtccc aagattacggacgtcaaaggcattggttgctcataaattttacctgaaat cagagccggaagcctatttctgcttattgaaggaacatcatcgtcgaaca ataaatcccgatttaacattcgatgcatcaaaatactcagaactacctca agttgaactatcacgaggtcttgccatgtcacaactgacacatcaaaatt ggattctatga
|
Protein
MVRFKFKTSLIIAIFFLFIYFSVESLFPRKQEDKNVSKQFLKSICTTASDSYLLDNMEIN CSNILKGYKTNEKLDIMHLDIIEEQLFSCTNKCQTLKTLFRFNTNPMSAEEKHFPLSYGM LVYKDLPQVLFLLSSIYHPQNEYCIAVGENSAPIFQNLLREVSTCFSNVHFMKRPPISWG SHEIIDSVYDCLEFLSHLETDWRYFQYLSGVDIPLKTNLEMVQILKHLNGTSNVEITNYQ QARLTGKNENESPLPLFKSSLSAIIPRKAANQLASSNTARKLLEFLWNTEIADEGFWGTL FGNKDQFNISGSINSKDWMEYRDNQNNIFNPTDGWSYYISRDQIWDPELCKNYMKDDSCV FGIGDVPRLRTSKALVAHKFYLKSEPEAYFCLLKEHHRRTINPDLTFDASKYSELPQVEL SRGLAMSQLTHQNWIL
|
References |
Warren CE, Krizus A, Dennis JW
Glycobiology
(2001)
11
(11)
:979-88
[PMID : 11744632]
Complementary expression patterns of six nonessential Caenorhabditis elegans core 2/I N-acetylglucosaminyltransferase homologues.
Berninsone PM
WormBook
(2006)
:1-22
[PMID : 18050430]
Carbohydrates and glycosylation.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
gly-19
gly-19 encodes a 2/I N-acetylglucosaminyltransferase; a gly-19::gfp promoter fusion is expressed in the intestine and in the anal sphincter muscle from embryogensis through adulthood.
|
Deletion Mutants |
|
In Situ |
In Situ
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Certain |
WB:Expr1787
|
WBPaper00005030
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00037950 : intestine_CoreEnriched, intestine_embryo_enriched, intestine_larva_enriched
|
WBPaper00037950
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00040985 : AIN-2_L4_intestine
|
WBPaper00040985
|
WormAtlas
|
WB |
WBbt:0005798
|
anal sphincter muscle |
"a saddle-shaped muscle cell that encircles the intestinal-rectal valve" [WB:rynl, WBPaper:00038216] |
Certain |
WB:Expr1787
|
WBPaper00005030
|
WormAtlas
|
|
WBGene00001644
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|