JCEG ID |
JCEG186 |
Name |
W02B12.1
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:B4GALT5
OMIM:
610179
OrthoList :
PLB1
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
|
0.000004
|
0.298
|
|
(unit decrease)] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
MAPPED |
0.11 |
0.000006
|
|
0.108
(kg/m2 increase)
|
[0.061-0.155] |
25811787
|
|
Huffman JE 2015-03-26 PLoS One
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans.
|
|
Family Name |
b4GalT |
Locus Tag |
W02B12.1
|
RNAi phenotype |
phenotype
|
WT
|
Microscope observation (Image)
|
|
COPAS (Image)
|
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
kr:Detected
gg_motif:M1,M2,M3,M4,M5
tm:Detected
dxd:DVD
|
Sequence |
CDS
atgcggtggttagttaccacgttgctatgttgctccctggctcatgggct caaggatctcggagctccgaactggtcgtgtgacgctagtgttatggcaa agagtaagaaagttcccaccagtgctcatagtgttcgatttgctgatatc aaggttattggagcacttggggactcgttgactgcagccaatggtgctgg agctcaaccaggagacccgctggcagtcatcctgcaatatagaggacttg ccttccagattggaggtgataaaagccttgatgagcacattactgttgca aatgtactaagaaagttcaatccaaccttggtgggtgcctcaaaaggaat cggctcggaaaacgtatgggaagtttctcacttgaatatgggagttcctg gagctgaatccaaggatattatcggtcaggcaagagctctggtcaacact atgcatgctcattctgaaattaacgtgaaagaagactggaaacttgtcaa cattttcattggggcaaacgatatttgtgtctattgtgaagatccgtact tcaactcgacggctcttcatggaaatgcaacttttgagaagaatatcatc gcagctgttcagattcttcaggataatctgccaagaacaattgtctcact gaccggaatgttcaacatgagaatgcttcgtaagattgacaagaagaagt atttctgcgaaggacttcatacattcgaatgtgattgtgagtccaacaaa caattcactgatgatgatattcaaggagtttgcttcggatatatgaatgc tgaaaaagatattcaaaacacgggattattcgataacaaggatgatttca cgtttgtagttcaaccatttttcaacgggattctggatccaccatacgcg agcccaggagttgttgacatgacattctttgctccagattgcttccattt ctcggcttacgggcatggaaatattggaatgcatctttggaacacaattg ttcaaccagttggattcaaacaaaccagtgtcaatttgagtgatccttca gttggattacattgcccaagtacaaactgtccgttcttcccgactacaaa aaacagcaataactgtgcttcacacttcacgttgagcgagctagattaa
|
Protein
MRWLVTTLLCCSLAHGLKDLGAPNWSCDASVMAKSKKVPTSAHSVRFADIKVIGALGDSL TAANGAGAQPGDPLAVILQYRGLAFQIGGDKSLDEHITVANVLRKFNPTLVGASKGIGSE NVWEVSHLNMGVPGAESKDIIGQARALVNTMHAHSEINVKEDWKLVNIFIGANDICVYCE DPYFNSTALHGNATFEKNIIAAVQILQDNLPRTIVSLTGMFNMRMLRKIDKKKYFCEGLH TFECDCESNKQFTDDDIQGVCFGYMNAEKDIQNTGLFDNKDDFTFVVQPFFNGILDPPYA SPGVVDMTFFAPDCFHFSAYGHGNIGMHLWNTIVQPVGFKQTSVNLSDPSVGLHCPSTNC PFFPTTKNSNNCASHFTLSELD
|
References |
|
Functional Descriptions |
W02B12.1
none available
|
Deletion Mutants |
ok639
tm1366
|
In Situ |
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00026980 : intestine_enriched
|
WBPaper00026980
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00037950 : intestine_CoreEnriched, intestine_embryo_SelectivelyEnriched, intestine_embryo_enriched, intestine_larva_SelectivelyEnriched, intestine_larva_enriched
|
WBPaper00037950
|
WormAtlas
|
|
WBGene00012201
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
germline proliferation variant
|
"Nuclear divisions in the germ line are either expanded are reduced compared to control." [WB:cab]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|