JCEG ID | JCEG185 | ||||||||||||||||||||||||
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Name | bre-4 WormBase NCBI Gene | ||||||||||||||||||||||||
Human Ortholog |
GGDB:B4GALT3 OrthoList : B4GALT3 B4GALT1 B4GALT2 (InParanoid)
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Family Name | b4GalT | ||||||||||||||||||||||||
Locus Tag | Y73E7A.7 | ||||||||||||||||||||||||
RNAi phenotype |
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Sequence Features |
kr:Detected tm:Detected dxd:DVD gg_motif:M1,M2,M3,M4,M5,M6 |
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Sequence | CDS |
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Protein |
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References |
Marroquin LD, Elyassnia D, Griffitts JS, Feitelson JS, Aroian RV Genetics (2000) 155 (4) :1693-9 [PMID : 10924467] Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans. Kawar ZS, Van Die I, Cummings RD J. Biol. Chem. (2002) 277 (38) :34924-32 [PMID : 12167666] Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans. Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, Muller R, Brown JR, Hennet T, Esko JD, Aroian RV J. Biol. Chem. (2003) 278 (46) :45594-602 [PMID : 12944392] Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions. Darby C WormBook (2005) :1-15 [PMID : 18050390] Interactions with microbial pathogens. Katic I, Vallier LG, Greenwald I Genetics (2005) 171 (4) :1605-15 [PMID : 16157663] New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme. Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation. Barrows BD, Haslam SM, Bischof LJ, Morris HR, Dell A, Aroian RV J. Biol. Chem. (2006) 282 (5) :3302-11 [PMID : 17135259] Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose. Ideo H, Fukushima K, Gengyo-Ando K, Mitani S, Dejima K, Nomura K, Yamashita K J. Biol. Chem. (2009) 284 (39) :26493-501 [PMID : 19635802] A Caenorhabditis elegans glycolipid-binding galectin functions in host defense against bacterial infection. Butschi A, Titz A, Walti MA, Olieric V, Paschinger K, Nobauer K, Guo X, Seeberger PH, Wilson IB, Aebi M, Hengartner MO, Kunzler M PLoS Pathog. (2010) 6 (1) :e1000717 [PMID : 20062796] Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. Zhang H, Abraham N, Khan LA, Hall DH, Fleming JT, Gobel V Nat. Cell Biol. (2011) 13 (10) :1189-201 [PMID : 21926990] Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. |
Functional Descriptions |
bre-4 bre-4 encodes a beta-1,4-N-acetylgalactosaminyltransferase that is required for the toxicity of Bacillus thuringiensis Cry5B. |
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Deletion Mutants | ok3167 | |||
In Situ | ||||
Expression | Expression | |||
WBGene00000269 Phenotype Homology_paralog |
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Phenotype | Definition | RNAi / Allele | ||
Bacillus thuringiensis toxin resistant
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"Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals." [GO:0042493, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557] |
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brood size variant
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"The number of offspring produced is altered compared to that of control animals." [WB:WBPerson557] |
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organism toxic chemical response variant
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"Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals." [WB:WBPerson557] |
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pore forming toxin resistant
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"Animals fail to respond to the concentration of pore forming toxins that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2987, WB:WBPerson557] |
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