JCEG ID | JCEG178 | |||||||||||||||||||||||||||||||||||||||
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Name | bre-5 WormBase NCBI Gene | |||||||||||||||||||||||||||||||||||||||
Human Ortholog |
GGDB:B3GALNT1 B3GALT4 B3GALT5 B3GNT3 B3GNT4 B3GNT6 B3GNT7 OMIM: OrthoList : B3GNT7 B3GNT5 B3GNT3 B3GNT9 B3GNT4 B3GNT6 B3GNT2 B3GNT8 (Ensembl Compara)
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Family Name | b3GalT1/b3GnT orthologs | |||||||||||||||||||||||||||||||||||||||
Locus Tag | T12G3.8 | |||||||||||||||||||||||||||||||||||||||
RNAi phenotype |
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Sequence Features |
tm:soluble dxd:Detected gg_motif:M1,M2,M3 |
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Sequence | CDS |
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Protein |
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References |
Marroquin LD, Elyassnia D, Griffitts JS, Feitelson JS, Aroian RV Genetics (2000) 155 (4) :1693-9 [PMID : 10924467] Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans. Griffitts JS, Whitacre JL, Stevens DE, Aroian RV Science (2001) 293 (5531) :860-4 [PMID : 11486087] Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme. Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, Muller R, Brown JR, Hennet T, Esko JD, Aroian RV J. Biol. Chem. (2003) 278 (46) :45594-602 [PMID : 12944392] Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions. Darby C WormBook (2005) :1-15 [PMID : 18050390] Interactions with microbial pathogens. Mylonakis E, Aballay A Infect. Immun. (2005) 73 (7) :3833-41 [PMID : 15972468] Worms and flies as genetically tractable animal models to study host-pathogen interactions. Greenwald I WormBook (2005) :1-16 [PMID : 18050403] LIN-12/Notch signaling in C. elegans. Katic I, Vallier LG, Greenwald I Genetics (2005) 171 (4) :1605-15 [PMID : 16157663] New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme. Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK Mol. Biol. Cell (2005) 16 (9) :4202-13 [PMID : 15987734] The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation. Yochem J, Herman RK WormBook (2005) :1-6 [PMID : 18023118] Genetic mosaics. Anyanful A, Dolan-Livengood JM, Lewis T, Sheth S, Dezalia MN, Sherman MA, Kalman LV, Benian GM, Kalman D Mol. Microbiol. (2005) 57 (4) :988-1007 [PMID : 16091039] Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene. Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation. Barrows BD, Haslam SM, Bischof LJ, Morris HR, Dell A, Aroian RV J. Biol. Chem. (2006) 282 (5) :3302-11 [PMID : 17135259] Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose. Ideo H, Fukushima K, Gengyo-Ando K, Mitani S, Dejima K, Nomura K, Yamashita K J. Biol. Chem. (2009) 284 (39) :26493-501 [PMID : 19635802] A Caenorhabditis elegans glycolipid-binding galectin functions in host defense against bacterial infection. Butschi A, Titz A, Walti MA, Olieric V, Paschinger K, Nobauer K, Guo X, Seeberger PH, Wilson IB, Aebi M, Hengartner MO, Kunzler M PLoS Pathog. (2010) 6 (1) :e1000717 [PMID : 20062796] Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. Los FC, Kao CY, Smitham J, McDonald KL, Ha C, Peixoto CA, Aroian RV Cell Host Microbe (2011) 9 (2) :147-57 [PMID : 21320697] RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin. Zhang H, Abraham N, Khan LA, Hall DH, Fleming JT, Gobel V Nat. Cell Biol. (2011) 13 (10) :1189-201 [PMID : 21926990] Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. |
Functional Descriptions |
bre-5 The bre-5 gene encodes a putative beta-1,3-galactosyltransferase that is predicted to transfer galactose onto proteins or lipids; BRE-5 is required for Cry5B toxicity. |
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Deletion Mutants | ||||||||||||||||||||||||||
In Situ | ||||||||||||||||||||||||||
Expression |
Expression
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WBGene00000270 Phenotype Homology_paralog |
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Phenotype | Definition | RNAi / Allele | ||||||||||||||||||||||||
Bacillus thuringiensis toxin resistant
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"Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals." [GO:0042493, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557] |
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organism toxic chemical response variant
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"Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals." [WB:WBPerson557] |
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pesticide response variant
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"Animals exhibit variations in their response to any chemical substance that is used for killing pests, compared to that observed in control animals." [WB:WBPerson557] |
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pore forming toxin resistant
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"Animals fail to respond to the concentration of pore forming toxins that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2987, WB:WBPerson557] |
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