JCEG ID JCEG165
Name uggt-1      WormBase    NCBI Gene
Human Ortholog

GGDB:UGGT1 UGGT2 

OMIM: 605897 605898

OrthoList :   UGGT1   UGGT2  (Ensembl Compara)

GGDB Score E-val
UGGT1 (UGCGL1) 1160 0.0
UGGT2 (UGCGL2) 1131 0.0
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name UGCGL1
Locus Tag F48E3.3
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features kr:Detected
gg_motif:M1, M2, M3, M4, M5, M6
tm:Detected
dxd:Detected
Sequence CDS
Protein
References

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Caruso ME, Jenna S, Bouchecareilh M, Baillie DL, Boismenu D, Halawani D, Latterich M, Chevet E Mol. Cell. Biol. (2008) 28 (13) :4261-74 [PMID : 18458060] GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48.

Lewis JA, Szilagyi M, Gehman E, Dennis WE, Jackson DA BMC Genomics (2009) 10 :202 [PMID : 19402892] Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans.

Buzzi LI, Simonetta SH, Parodi AJ, Castro OA PLoS ONE (2011) 6 (11) :e27025 [PMID : 22073243] The two Caenorhabditis elegans UDP-glucose:glycoprotein glucosyltransferase homologues have distinct biological functions.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

WormBase (WS254)

Functional Descriptions uggt-1

uggt-1 encodes one of two C. elegans homologs of UDP-Glc:glycoprotein glucosyltransferase (UGGT), an endoplasmic reticulum enzyme involved in quality control of glycoprotein folding; expression of uggt-1 in S. pombe cells lacking functional UGGT activity indicates that UGGT-1 displays UDP-Glc:glycoprotein glucosyltransferase activity; loss of uggt-1 activity via RNAi results in larval developmental delay and a shortened lifespan; uggt-1 is expressed throughout larval development, with peak levels seen at the L2/L3 stages, and uggt-1 expression is upregulated in an ire-1-dependent manner in response to endoplasmic reticulum stress; a uggt-1::gfp promoter fusion is expressed in the nervous system, including the amphid and phasmid neurons, the nerve ring, and the dorsal and ventral nerve cords.
Deletion Mutants
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0005788

pharyngeal gland cell "secretory gland cell of the pharynx" [WB:rynl] WB:Expr6112 WBPaper00006525 WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] WB:Expr6112 WBPaper00006525 WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00030839 : Embryo_Pan_Neuronal
WBPaper00030839 WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Certain WB:Expr11245 WBPaper00031857 WormAtlas
WB WBbt:0003681

pharynx "the feeding organ, a neuro-muscular pump in the head of the animal, used to ingest food, bacteria suspended in liquid, filter them out, grind them up and transport posteriorly into the instestine." [WB:rynl] WB:Expr6112 WBPaper00006525 WormAtlas
WB WBbt:0003681

pharynx "the feeding organ, a neuro-muscular pump in the head of the animal, used to ingest food, bacteria suspended in liquid, filter them out, grind them up and transport posteriorly into the instestine." [WB:rynl] Enriched WBPaper00029359 WormAtlas
WB WBbt:0004017

Cell "a cellular object that consists of subcellular components, expresses genes or functions." [WB:rynl] Certain WB:Expr4054 WBPaper00027758
WB WBbt:0004740

I5 neuron "Neuron class of one pharyngeal interneuron, posterior sensory." [ISBN:0-87969-307-X] Enriched WBPaper00025141 : unc-4
WBPaper00025141
WB WBbt:0005278

DA neuron "Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] Enriched WBPaper00025141 : unc-4
WBPaper00025141
WB WBbt:0005278

DA neuron "Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] Enriched WBPaper00030839 : Embryo_A_Class
WBPaper00030839
WB WBbt:0005300

ventral cord neuron "neuron with cell body associated with the ventral nerve cord." [WB:Paper00000938] WB:Expr6112 WBPaper00006525 WormAtlas
WB WBbt:0005394

amphid neuron "neuron of the amphid sensillum" [WB:rynl] Certain WB:Expr9683 WBPaper00040397 WormAtlas
WB WBbt:0005396

SAB "Neuron class of three interneurons, which send processes anteriorly up the sub-lateral cords in the head." [WB:Paper00000938] Enriched WBPaper00025141 : unc-4
WBPaper00025141
WB WBbt:0005656

retrovesicular ganglion "ganglion that lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore. It is open and continuous with the region containing the motoneurons of the ventral cord. In the early L1 this ganglion holds 12 neuron cell bodies plus one neuroblast (Sulston and Horvitz, 1977; White et al., 1986). In the adult animal, the ganglion holds 20 neuron cell bodies.\nReversal \n\n" [WBPaper:00038216] Enriched WBPaper00025141 : unc-4
WBPaper00025141 WormAtlas
WB WBbt:0005662

AFD "Neuron class of two ciliated neurons that are part of the amphid sensillum; the endings of AFD have numerous villi, which poke into the amphid sheath cells." [WB:Paper00000938] Enriched WBPaper00024671 : AFD_AWB_vs_unsorted_upregulated
WBPaper00024671
WB WBbt:0005671

AWB "Neuron class of two ciliated neurons with flattened, sheet-like endings that are associated with the sheath cells of the amphid sensilla" [WB:Paper00000938] Enriched WBPaper00024671 : AFD_AWB_vs_unsorted_upregulated
WBPaper00024671
WB WBbt:0005735

nervous system "Complement of nervous tissue (neurones, nerves, receptors and support cells) serving to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities." [ISBN:0-14-051288-8, WB:rynl] WB:Expr6111|WB:Expr6112 WBPaper00006525 WormAtlas
WB WBbt:0005735

nervous system "Complement of nervous tissue (neurones, nerves, receptors and support cells) serving to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities." [ISBN:0-14-051288-8, WB:rynl] Certain WB:Expr9683 WBPaper00040397 WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00037950 : intestine_embryo_enriched
WBPaper00037950 WormAtlas
WB WBbt:0005784

germ line "cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes." [ISBN:0140512888] Certain WB:Expr4054 WBPaper00027758
WB WBbt:0005812

excretory cell "H-shaped cell associated with the excretory system, largest cell in C. elegans." [WB:rynl] WB:Expr6112 WBPaper00006525 WormAtlas
WB WBbt:0005813

body wall musculature "Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] Enriched WBPaper00029359 WormAtlas
WB WBbt:0005821

vulval muscle "muscle associated with hermaphrodite vulva." [WB:rynl] Enriched WBPaper00029359 WormAtlas
WB WBbt:0005829

ventral nerve cord "a large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring." [WB:Paper00000938] Enriched WBPaper00029359 WormAtlas
WB WBbt:0005829

ventral nerve cord "a large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring." [WB:Paper00000938] Certain WB:Expr11245 WBPaper00031857 WormAtlas
WB WBbt:0005829

ventral nerve cord "a large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring." [WB:Paper00000938] Certain WB:Expr9683 WBPaper00040397 WormAtlas
WB WBbt:0006749

nerve ring "the most extensive region of neuropil in the animal, consists of a large toroidal bundle of processes." [WB:Paper00000938] WB:Expr6112 WBPaper00006525 WormAtlas
WB WBbt:0006749

nerve ring "the most extensive region of neuropil in the animal, consists of a large toroidal bundle of processes." [WB:Paper00000938] Enriched WBPaper00029359 WormAtlas
WB WBbt:0006749

nerve ring "the most extensive region of neuropil in the animal, consists of a large toroidal bundle of processes." [WB:Paper00000938] Certain WB:Expr11245 WBPaper00031857 WormAtlas
WB WBbt:0006750

dorsal nerve cord "a bundle of nerve processes that runs along the dorsal mid-line of the animal." [WB:Paper00000938] Enriched WBPaper00029359 WormAtlas
WB WBbt:0006750

dorsal nerve cord "a bundle of nerve processes that runs along the dorsal mid-line of the animal." [WB:Paper00000938] Certain WB:Expr9683 WBPaper00040397 WormAtlas
WB WBbt:0006751

head neuron "neuron with its cell body situated in the head, excluding the pharynx." [WB:rynl] WB:Expr6111|WB:Expr6112 WBPaper00006525
WB WBbt:0006751

head neuron "neuron with its cell body situated in the head, excluding the pharynx." [WB:rynl] Certain WB:Expr11245 WBPaper00031857
WB WBbt:0006752

somatic neuron "neuron of the somatic nervous system." [WB:rynl] Enriched WBPaper00029359
WB WBbt:0006753

phasmid neuron "neuron of phasmid sensillum" [WB:rynl] Certain WB:Expr9683 WBPaper00040397 WormAtlas
WB WBbt:0006759

tail neuron "neuron with its cell body situated in the tail, posterior to rectum." [WB:rynl] WB:Expr6111|WB:Expr6112 WBPaper00006525
WB WBbt:0006759

tail neuron "neuron with its cell body situated in the tail, posterior to rectum." [WB:rynl] Enriched WBPaper00029359
WB WBbt:0006759

tail neuron "neuron with its cell body situated in the tail, posterior to rectum." [WB:rynl] Certain WB:Expr9683 WBPaper00040397
WB WBbt:0006769

lateral nerve cord "nerve cord positioned at the lateral flanks of the animal, consists of processes of the neuron classes BDU, CAN, PVD and ALA." [WB:rynl] Enriched WBPaper00029359
WB WBbt:0006974

nerve ring neuron "neuron that has neural processes in the nerve ring." [WB:rynl] Certain WB:Expr9683 WBPaper00040397 WormAtlas

WBGene00018604
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
developmental delay

"The developmental progression of an animal over time, from its formation to its mature structure is delayed compared to control." [WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00093463   WBPaper00040397   Observed
enzyme activity reduced

"Any variation that results in a decrease in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00093459   WBPaper00040397   Observed
shortened life span

"The duration of viability in the adult phase of the life-cycle is less than that of control animals." [GO:0008340, WB:WBPerson712]
RNAi: WBRNAi00093461   WBPaper00040397   Observed
tunicamycin hypersensitive

"Animals respond to tunicamycin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00030877, WB:WBPerson557]
RNAi: WBRNAi00093465   WBPaper00040397   Observed


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