JCEG ID |
JCEG164 |
Name |
uggt-2
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:UGGT1
OMIM:
605897
605898
OrthoList :
UGGT1
UGGT2
(Ensembl Compara)
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
UGCGL1 |
Locus Tag |
F26H9.8
|
RNAi phenotype |
phenotype
|
Emb
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Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
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|
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Sequence Features |
kr:Detected
gg_motif:M1, M2, M3, M4, M5, M6
tm:Detected
dxd:Detected
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Sequence |
CDS
atgcgtttaacacactttctattgtttcttgcaaatttaaagttttgctg gaatgacaattcaataaacgttcgtcttaatgccaagtggaggtcatcct cgattttggccgaaattagtgagtatattggaaaagaaaaccccgaagca ttctggaattttgtgaatagtgtcaaccaggaaatcgatgaaacttccaa caaaaatgattctattcgcaataaatatgattttggtatgtcggttgcaa acaatattctcggcccatttgaaatgaagcttctccgtttttcattggct actagatcaatatcacctagagtacaggctcatgagcaaattggaatgga attcaaaccagaaaaatgttcattttcgttttttgtatatggtggtcagg cgggatgtcagttgagtgagctgaatcttaataattatgatgataacaat ttaaaaatcttttcatttgatcatatttacccagttcaatcaaccgctga gaaaactattttaatttatggagaacttggcacttacgaactcaagaatc tccttcttgaagctcaaagtctgatcgaaaagcacaaaaatctcagattc gtggttcgccacttttctagattttcagatcaaaagccttcattatctgg ttatggagtggaacttgctttgaaaaacacggaatacaaggctgtggatt cttcgtcaaccaataaattggatgaacctgagaaccttcatggattgaat ttcaaaattctaaaaaatcggcacttggaattgcagaacgagttggaatc tttacgtgaaaatcttgaaaaacaaggagaaattgtgccgttaaagcagt ggcagctaaaagatttgggttttaaaacgtgccaaaaactgaaaagtttg accgaaattcgtgaaatggaaattctactgcaggattttcctacacatgc cagggtaacatctcatcaaaatctcaatgaaacattgcaaagatcaatac aaaaaggacaagaaactctcgaagcaaaaggaattgaatcaggaacaaat attttggcaattaacggaagagttattgctaaaggagactcatttgttga tttatttgctttgatggaaaaagtagaagaagagaagaaaatggtcaatg aatttgtgaaagggttcggaaattcagaaactgaggaattcgagagaatc aatattcccaaaatgcttaccttggtggatttatcttcagtgaaactatc tgaacacgcatttgattattccattgccgagcctgtttatctgaacgatc tggaatcaacaagaagtccatataaatctcttatgctaatgcttcaacca ttccctcctggccaaatccgaccaatttctcggaatatatttaacctgat tatgtttcttgatccgtttgattcagacgacagagttttcgatgatgtta tcagaaatttccaaacaggaattcatattagatttggtttcgtgccgatt ctcgacgaagcgaaatatggaaaaagcatagaagaagctgtagattctat gattgttcctcctacaaaaaaagttttttggaagtcaaaggatagtctaa tcaatgctttgaagaaaggtagtcgatttgtggctgaagctggtctaacc caattaccacttgttctactcaacggatatccattagatgtgacatcaat tgaaagatttgaatcttcgttgacacaaaatattcaaaaacaaacaacac gactccaacttgcattacttcatggactaattgaagattctgtacaaatt gatcgttggtggttcgagaaaaagacaaatccggatattattcaacgcct taatcagaggatcactacggcattcaacaataaggaatttttgaatatca gcagaagatctattcaatttttaaagaatgtgcactatttctcggaggaa tctgatacagttttagcgaatgcggatgttacaacatggattattgctga ttttgagaatccatcaaatcggttatttgctaccaaagctattcgatcta ttgcatctcagaaaaataataagattgcactgatcccaaatccatcaagc tctcggagcaacgacaatccatgctcgttcaattttgaaaatgttggacc aaactctgacatgacgattctatcaaaaattgagagtttttgtatgaaaa atattaatttatctcctttggatattggagttaatcctggagaaacggtt gtagtgtcgaatggattgctaattgggcctcttgctggaagaactgagct tttgaaaacggatgatttcaattatttggatacattttggaaagagaaag gagcaacaaaagctgcaacgtttttcaacgaaaatacagtgtatgacgtc actatcagtttctactgctctatcgcaaaaaaatttaaagaagaccagca aagaatggattttgatgagttcatggaatcaggaaatggaaatacaatca tatttcctccaattgattccaccaattcaacaattactgtaacttggatc gccaatccagtatcacgagaagctcaacaaataatttcagtcgttaaaat tctgcaaagaatcaccaattcacgaatcgaaataatcttcaatccgtctg ccgatattcaagaaatgcccattaaacgattttatcgatttgttgcaaac gaaaagcttttgtttaatgaagatggatcaatggaaaatcattctgtagt attctcaaatcttcctcaaaaacaattattgacaatgtctcttgagacaa atgatgcttggatgattgaagtgaaaaaggcggaatatgatttagataat attctattagaaacagcatcagaggacgttgaagcagtttacagcttgga gcatattcttgtcgaaggtacatctcggaagatgagtggagaagcatcag atggattggaagttgaattgagttcgggtggcaagaactatgacacaata gtcatgttgaacttaggatattttcaattgaaggctgaaccaggagtttg gaatctgcatttaagaaatggacattcggcggacgaacacaaaattgtga cgattgactcgattccagttgagaatgatattcaaattgttgttgactcg ttttctggaaaatgggtagaactttctgttgaggagcttaccgaaccgaa agagtcagatgacgagttatcaattgaaagtcttttgaacagtgctaaaa actacttcgcatcacctgaaccatcagaagtcataaatgtattttcgctt gcttctggtcatctctacgaacgtttcatgcggattatgatgacttccgt cttgaataacacgaaaacacaaaaagtcaaattctggcttctcaagaact acttatcgccaaaattcaaagaaacgattcccaaattggcggaattctat aagtttgaattcgagcttgtcgagtacaaatggccaaaatggttgcataa acaaacggaaaaacaaagagttatgtggggatacaagattctatttttgg atgttttatttcctctaaatgtggataaaatcatcttcgtagatgccgat caagttgttcgagctgatttacaagaattgatggatttcaatttaaatgg ggctccttatggatatgttccattttgtgagagtcgaacagagatggatg gattccgattttggaaaagtggatattggaagaatcatttgatggggcga aaatatcatattagtgcactttatgttgttgatcttaaggcgttccgcga gttctcagctggagaccgccttcgtggtcggtacgacagcctatctgctg atccgaacagtctttcgaatttggatcaagatcttccgaacaacatgctt cacgaagttcctattaaatcattacctcaggaatggctttggtgtgagac atggtgtgatgatggaagtaaagaaaaggcaaaaacaattgacttgtgca acaatccactgacaaaagaaccaaaactgaactcggcaaaacgtattatc aaagaatggacagaatacgattcagaaatttcgaaagttttgaattctgc agatatcaacactccatcaccatcagtggatcgagatgaattatga
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Protein
MRLTHFLLFLANLKFCWNDNSINVRLNAKWRSSSILAEISEYIGKENPEAFWNFVNSVNQ EIDETSNKNDSIRNKYDFGMSVANNILGPFEMKLLRFSLATRSISPRVQAHEQIGMEFKP EKCSFSFFVYGGQAGCQLSELNLNNYDDNNLKIFSFDHIYPVQSTAEKTILIYGELGTYE LKNLLLEAQSLIEKHKNLRFVVRHFSRFSDQKPSLSGYGVELALKNTEYKAVDSSSTNKL DEPENLHGLNFKILKNRHLELQNELESLRENLEKQGEIVPLKQWQLKDLGFKTCQKLKSL TEIREMEILLQDFPTHARVTSHQNLNETLQRSIQKGQETLEAKGIESGTNILAINGRVIA KGDSFVDLFALMEKVEEEKKMVNEFVKGFGNSETEEFERINIPKMLTLVDLSSVKLSEHA FDYSIAEPVYLNDLESTRSPYKSLMLMLQPFPPGQIRPISRNIFNLIMFLDPFDSDDRVF DDVIRNFQTGIHIRFGFVPILDEAKYGKSIEEAVDSMIVPPTKKVFWKSKDSLINALKKG SRFVAEAGLTQLPLVLLNGYPLDVTSIERFESSLTQNIQKQTTRLQLALLHGLIEDSVQI DRWWFEKKTNPDIIQRLNQRITTAFNNKEFLNISRRSIQFLKNVHYFSEESDTVLANADV TTWIIADFENPSNRLFATKAIRSIASQKNNKIALIPNPSSSRSNDNPCSFNFENVGPNSD MTILSKIESFCMKNINLSPLDIGVNPGETVVVSNGLLIGPLAGRTELLKTDDFNYLDTFW KEKGATKAATFFNENTVYDVTISFYCSIAKKFKEDQQRMDFDEFMESGNGNTIIFPPIDS TNSTITVTWIANPVSREAQQIISVVKILQRITNSRIEIIFNPSADIQEMPIKRFYRFVAN EKLLFNEDGSMENHSVVFSNLPQKQLLTMSLETNDAWMIEVKKAEYDLDNILLETASEDV EAVYSLEHILVEGTSRKMSGEASDGLEVELSSGGKNYDTIVMLNLGYFQLKAEPGVWNLH LRNGHSADEHKIVTIDSIPVENDIQIVVDSFSGKWVELSVEELTEPKESDDELSIESLLN SAKNYFASPEPSEVINVFSLASGHLYERFMRIMMTSVLNNTKTQKVKFWLLKNYLSPKFK ETIPKLAEFYKFEFELVEYKWPKWLHKQTEKQRVMWGYKILFLDVLFPLNVDKIIFVDAD QVVRADLQELMDFNLNGAPYGYVPFCESRTEMDGFRFWKSGYWKNHLMGRKYHISALYVV DLKAFREFSAGDRLRGRYDSLSADPNSLSNLDQDLPNNMLHEVPIKSLPQEWLWCETWCD DGSKEKAKTIDLCNNPLTKEPKLNSAKRIIKEWTEYDSEISKVLNSADINTPSPSVDRDE L
|
References |
Berninsone PM
WormBook
(2006)
:1-22
[PMID : 18050430]
Carbohydrates and glycosylation.
Buzzi LI, Simonetta SH, Parodi AJ, Castro OA
PLoS ONE
(2011)
6
(11)
:e27025
[PMID : 22073243]
The two Caenorhabditis elegans UDP-glucose:glycoprotein glucosyltransferase homologues have distinct biological functions.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
uggt-2
uggt-2 encodes one of two C. elegans homologs of UDP-Glc:glycoprotein glucosyltransferase (UGGT), an endoplasmic reticulum enzyme involved in quality control of glycoprotein folding; loss of uggt-2 activity via RNAi indicates that uggt-2 is an essential embryonic gene that is also required for regulating the rate of larval developmental; uggt-2 interacts genetically with ire-1 with respect to basal unfolded protein response during larval development; uggt-2 is expressed throughout larval development, with peak levels seen at the L2/L3 stages.
|
Deletion Mutants |
tm2318
gk1680
ok2510
|
In Situ |
In Situ
|
Expression |
Expression
|
WBGene00009178
Phenotype
Homology_paralog
|
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Phenotype |
Definition |
RNAi / Allele |
developmental delay
|
"The developmental progression of an animal over time, from its formation to its mature structure is delayed compared to control." [WB:WBPerson2021, WB:WBPerson557]
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embryonic lethal
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"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
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enzyme activity variant
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"Any variation in the function of naturally occurring macromolecular substances known as enzymes compared to control. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [GO:0003824, WB:WBPerson2021, WB:WBPerson557]
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germline proliferation variant
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"Nuclear divisions in the germ line are either expanded are reduced compared to control." [WB:cab]
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larval arrest
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"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
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larval lethal
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"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
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lethal
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"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
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life span variant
|
"Adult life span is either longer or shorter than typical of control animals." [GO:0008340, WB:cab, WB:WBPaper00005863, WB:WBPaper00026717, WB:WBPerson557]
|
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maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
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organism hypersensitive desication
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"Animals respond to less severe drought-like conditions or a shorter exposure compared to control animals." [WB:WBPerson2021]
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organism morphology variant
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"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
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postembryonic development variant
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"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
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slow growth
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"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
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sterile progeny
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"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
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tunicamycin hypersensitive
|
"Animals respond to tunicamycin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00030877, WB:WBPerson557]
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Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
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