JCEG ID |
JCEG158 |
Name |
hst-3.1
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:HS3ST1
OMIM:
OrthoList :
HS3ST1
(Ensembl Compara)
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
Sulfotransferase and sulfation-related genes |
Locus Tag |
F40H3.5
|
RNAi phenotype |
phenotype
|
oocyte morpholigy variant (50% n=10, see reference)
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
|
Sequence |
CDS
atggtcaagttttcaacaagatgtgtagttgcttgtctattgacaattgg aatgtgcttcttacagtataacttattttttcgaaatttcaagttcaaat ggtggatagatttaggaaaaggcgagaaatctcatttggagaaaaaattc ccatcggctttaatagttggagtacggaaaggaggaacacgtgcattact agacgcaatcgctcttcacccaaaagttcgaattgtgagacgagaaactc atttctttgattcaaattacacacttggatttgattggtatcgagatcaa atgcctgaagtcgaaaatgataacgaaattgtcatcgaaaaaacgccagc gtacttcacaaatgagcatgttcccaaaagagtttacgaaatgaatccag atatgaaacttattttaattgttcgacatcctgtatatagaactgttagt gacttcacacaggtatactacaacaaattggaacaaaataaaacacttcc agtgctatcagtggaagcatttaaaacgaatgaagctggaattgagaaaa tcaatatggagtataaaccaatgacaaattctctttacgatgttcatatt tcaaaatggctcaagtactttgatctcaaaaattttctttttgtgaatgg agatgttttcagagcaaacccccttcgtgagttacggaaagtggaagaat tcttaggattagagagatcgattaccccgagccaattggtttttgattac aataagggattcttttgctttcgaaaaactacaaaagttcgatgtttggg actgtcaaaaggtcgaaagcatcgatcagtaagcgaagatgttgtggcta aactatcaaatatgtttgaagagcacaatcaaaactttttccggttaatc aatcgaacatattcctgggaataa
|
Protein
MVKFSTRCVVACLLTIGMCFLQYNLFFRNFKFKWWIDLGKGEKSHLEKKFPSALIVGVRK GGTRALLDAIALHPKVRIVRRETHFFDSNYTLGFDWYRDQMPEVENDNEIVIEKTPAYFT NEHVPKRVYEMNPDMKLILIVRHPVYRTVSDFTQVYYNKLEQNKTLPVLSVEAFKTNEAG IEKINMEYKPMTNSLYDVHISKWLKYFDLKNFLFVNGDVFRANPLRELRKVEEFLGLERS ITPSQLVFDYNKGFFCFRKTTKVRCLGLSKGRKHRSVSEDVVAKLSNMFEEHNQNFFRLI NRTYSWE
|
References |
Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G
Nature
(2003)
421
(6920)
:268-72
[PMID : 12529643]
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.
Bhattacharya R, Townley RA, Berry KL, Bulow HE
J. Cell. Sci.
(2009)
122
(Pt 24)
:4492-504
[PMID : 19920077]
The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
Attreed M, Desbois M, van Kuppevelt TH, Bulow HE
Nat. Methods
(2012)
9
(5)
:477-9
[PMID : 22466794]
Direct visualization of specifically modified extracellular glycans in living animals.
Tecle E, Diaz-Balzac CA, Bulow HE
G3 (Bethesda)
(2013)
3
(3)
:541-52
[PMID : 23451335]
Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans.
Berninsone PM, Hirschberg CB
Glycoconj. J.
19
(4-5)
:325-30
[PMID : 12975612]
The nematode Caenorhabditis elegans as a model to study the roles of proteoglycans.
|
Functional Descriptions |
hst-3.1
|
Deletion Mutants |
tm734
ok1249
|
In Situ |
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0003675
|
muscle cell |
"contractile cell that makes up muscle tissue." [WB:rynl] |
Enriched |
WBPaper00031003 : 0hr_muscle_enriched, 24hr_muscle_enriched, total_muscle_enriched
|
WBPaper00031003
|
WormAtlas
|
WB |
WBbt:0003681
|
pharynx |
"the feeding organ, a neuro-muscular pump in the head of the animal, used to ingest food, bacteria suspended in liquid, filter them out, grind them up and transport posteriorly into the instestine." [WB:rynl] |
Enriched |
WBPaper00024505 : pharyngeal_enriched
|
WBPaper00024505
|
WormAtlas
|
WB |
WBbt:0003681
|
pharynx |
"the feeding organ, a neuro-muscular pump in the head of the animal, used to ingest food, bacteria suspended in liquid, filter them out, grind them up and transport posteriorly into the instestine." [WB:rynl] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0003825
|
B cell |
"Rectal cell, postembryonic blast cell in male" [ISBN:0-87969-307-X] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0003928
|
RIH |
"Neuron class of one ring interneuron." [ISBN:0-87969-307-X] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0004386
|
PDA |
"Neuron class of one motor neuron, process in dorsal cord, same as Y cell in hermaphrodite, Y.a in male." [ISBN:0-87969-307-X] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0004446
|
NSMR |
"Pharyngeal neurosecretory motorneuron, contain serotonin" [ISBN:0-87969-307-X] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0004457
|
NSML |
"Pharyngeal neurosecretory motorneuron, contain serotonin" [ISBN:0-87969-307-X] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0004499
|
K cell |
"Rectal cell, postembryonic blast cell" [ISBN:0-87969-307-X] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0004578
|
Y cell |
"Rectal cell at hatching, becomes PDA in hermaphrodite, postembryonic blast cell in male" [ISBN:0-87969-307-X] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0004799
|
F cell |
"Rectal cell, blast cell in male" [ISBN:0-87969-307-X] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0004942
|
U cell |
"Rectal cell, postembryonic blast cell in male" [ISBN:0-87969-307-X] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0005045
|
RIS |
"Neuron class of one ring interneuron." [ISBN:0-87969-307-X] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0005406
|
ALM |
"Neuron class of two anterior sensory neurons that transduce touch stimuli." [WB:Paper00000938] |
Enriched |
WBPaper00040420 : ALM_PLM_enriched
|
WBPaper00040420
|
|
WB |
WBbt:0005451
|
pharyngeal muscle cell |
"type of cells that make up muscle layers in the pharynx." [WB:rynl] |
Certain |
WB:Expr11890
|
WBPaper00045532
|
WormAtlas
|
WB |
WBbt:0005490
|
PLM |
"Neuron class of two posterior sensory neurons that transduce touch stimuli." [WB:Paper00000938] |
Enriched |
WBPaper00040420 : ALM_PLM_enriched
|
WBPaper00040420
|
|
WB |
WBbt:0005751
|
coelomocyte |
"A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0005800
|
rectal epithelium |
"epithelium connecting intestine and anus." [WB:rynl] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0005813
|
body wall musculature |
"Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] |
Enriched |
WBPaper00040985 : AIN-2_asynchronous_muscle
|
WBPaper00040985
|
WormAtlas
|
WB |
WBbt:0005813
|
body wall musculature |
"Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0005813
|
body wall musculature |
"Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] |
Certain |
WB:Expr11890
|
WBPaper00045532
|
WormAtlas
|
WB |
WBbt:0005821
|
vulval muscle |
"muscle associated with hermaphrodite vulva." [WB:rynl] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
WB |
WBbt:0006751
|
head neuron |
"neuron with its cell body situated in the head, excluding the pharynx." [WB:rynl] |
Partial |
WB:Expr10713
|
WBPaper00041895
|
|
WB |
WBbt:0006804
|
body wall muscle cell |
"type of 95 cells that make up muscles of the body wall." [WB:rynl] |
Enriched |
WBPaper00037950 : bodywall-muscle_CoreEnriched, bodywall-muscle_embryo_SelectivelyEnriched, bodywall-muscle_embryo_enriched, bodywall-muscle_larva_SelectivelyEnriched, bodywall-muscle_larva_enriched
|
WBPaper00037950
|
|
WB |
WBbt:0006831
|
PVD |
"Neuron class of two interneurons with cell bodies situated laterally in the posterior body." [WB:Paper00000938] |
Enriched |
WBPaper00036375 : enriched_in_PVD_OLL
|
WBPaper00036375
|
|
WB |
WBbt:0006847
|
OLL |
"Neuron class of two neurons with ciliated endings in the lateral outer labial sensilla." [WB:Paper00000938] |
Enriched |
WBPaper00036375 : enriched_in_PVD_OLL
|
WBPaper00036375
|
|
WB |
WBbt:0006865
|
DTC |
"somatic cell that situates at the tip of a gonad arm." [WB:rynl] |
Certain |
WB:Expr10713
|
WBPaper00041895
|
WormAtlas
|
|
WBGene00002030
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
fat content reduced
|
"Animals exhibit less fat or lipid than observed in control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712]
|
|
fat content variant
|
"Animals exhibit variations in the amount of fat or lipids present in the organism compared to control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|