JCEG ID JCEG158
Name hst-3.1      WormBase    NCBI Gene
Human Ortholog

GGDB:HS3ST1 

OMIM:

OrthoList :   HS3ST1  (Ensembl Compara)

GGDB Score E-val
HS3ST1 235 8e-64
HS3ST4 233 3e-63
HS3ST5 217 2e-58
HS3ST2 212 5e-57
HS3ST3A1 211 1e-56
HS3ST3B1 211 1e-56
NDST4 121 2e-29
NDST2 120 3e-29
NDST3 119 9e-29
NDST1 111 2e-26
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name Sulfotransferase and sulfation-related genes
Locus Tag F40H3.5
RNAi phenotype
phenotype oocyte morpholigy variant (50% n=10, see reference)
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G Nature (2003) 421 (6920) :268-72 [PMID : 12529643] Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.

Bhattacharya R, Townley RA, Berry KL, Bulow HE J. Cell. Sci. (2009) 122 (Pt 24) :4492-504 [PMID : 19920077] The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Attreed M, Desbois M, van Kuppevelt TH, Bulow HE Nat. Methods (2012) 9 (5) :477-9 [PMID : 22466794] Direct visualization of specifically modified extracellular glycans in living animals.

Tecle E, Diaz-Balzac CA, Bulow HE G3 (Bethesda) (2013) 3 (3) :541-52 [PMID : 23451335] Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans.

Berninsone PM, Hirschberg CB Glycoconj. J. 19 (4-5) :325-30 [PMID : 12975612] The nematode Caenorhabditis elegans as a model to study the roles of proteoglycans.

WormBase (WS254)

Functional Descriptions hst-3.1

Deletion Mutants tm734 ok1249
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003675

muscle cell "contractile cell that makes up muscle tissue." [WB:rynl] Enriched WBPaper00031003 : 0hr_muscle_enriched, 24hr_muscle_enriched, total_muscle_enriched
WBPaper00031003 WormAtlas
WB WBbt:0003681

pharynx "the feeding organ, a neuro-muscular pump in the head of the animal, used to ingest food, bacteria suspended in liquid, filter them out, grind them up and transport posteriorly into the instestine." [WB:rynl] Enriched WBPaper00024505 : pharyngeal_enriched
WBPaper00024505 WormAtlas
WB WBbt:0003681

pharynx "the feeding organ, a neuro-muscular pump in the head of the animal, used to ingest food, bacteria suspended in liquid, filter them out, grind them up and transport posteriorly into the instestine." [WB:rynl] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0003825

B cell "Rectal cell, postembryonic blast cell in male" [ISBN:0-87969-307-X] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0003928

RIH "Neuron class of one ring interneuron." [ISBN:0-87969-307-X] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0004386

PDA "Neuron class of one motor neuron, process in dorsal cord, same as Y cell in hermaphrodite, Y.a in male." [ISBN:0-87969-307-X] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0004446

NSMR "Pharyngeal neurosecretory motorneuron, contain serotonin" [ISBN:0-87969-307-X] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0004457

NSML "Pharyngeal neurosecretory motorneuron, contain serotonin" [ISBN:0-87969-307-X] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0004499

K cell "Rectal cell, postembryonic blast cell" [ISBN:0-87969-307-X] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0004578

Y cell "Rectal cell at hatching, becomes PDA in hermaphrodite, postembryonic blast cell in male" [ISBN:0-87969-307-X] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0004799

F cell "Rectal cell, blast cell in male" [ISBN:0-87969-307-X] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0004942

U cell "Rectal cell, postembryonic blast cell in male" [ISBN:0-87969-307-X] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0005045

RIS "Neuron class of one ring interneuron." [ISBN:0-87969-307-X] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0005406

ALM "Neuron class of two anterior sensory neurons that transduce touch stimuli." [WB:Paper00000938] Enriched WBPaper00040420 : ALM_PLM_enriched
WBPaper00040420
WB WBbt:0005451

pharyngeal muscle cell "type of cells that make up muscle layers in the pharynx." [WB:rynl] Certain WB:Expr11890 WBPaper00045532 WormAtlas
WB WBbt:0005490

PLM "Neuron class of two posterior sensory neurons that transduce touch stimuli." [WB:Paper00000938] Enriched WBPaper00040420 : ALM_PLM_enriched
WBPaper00040420
WB WBbt:0005751

coelomocyte "A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0005800

rectal epithelium "epithelium connecting intestine and anus." [WB:rynl] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0005813

body wall musculature "Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] Enriched WBPaper00040985 : AIN-2_asynchronous_muscle
WBPaper00040985 WormAtlas
WB WBbt:0005813

body wall musculature "Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0005813

body wall musculature "Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] Certain WB:Expr11890 WBPaper00045532 WormAtlas
WB WBbt:0005821

vulval muscle "muscle associated with hermaphrodite vulva." [WB:rynl] Certain WB:Expr10713 WBPaper00041895 WormAtlas
WB WBbt:0006751

head neuron "neuron with its cell body situated in the head, excluding the pharynx." [WB:rynl] Partial WB:Expr10713 WBPaper00041895
WB WBbt:0006804

body wall muscle cell "type of 95 cells that make up muscles of the body wall." [WB:rynl] Enriched WBPaper00037950 : bodywall-muscle_CoreEnriched, bodywall-muscle_embryo_SelectivelyEnriched, bodywall-muscle_embryo_enriched, bodywall-muscle_larva_SelectivelyEnriched, bodywall-muscle_larva_enriched
WBPaper00037950
WB WBbt:0006831

PVD "Neuron class of two interneurons with cell bodies situated laterally in the posterior body." [WB:Paper00000938] Enriched WBPaper00036375 : enriched_in_PVD_OLL
WBPaper00036375
WB WBbt:0006847

OLL "Neuron class of two neurons with ciliated endings in the lateral outer labial sensilla." [WB:Paper00000938] Enriched WBPaper00036375 : enriched_in_PVD_OLL
WBPaper00036375
WB WBbt:0006865

DTC "somatic cell that situates at the tip of a gonad arm." [WB:rynl] Certain WB:Expr10713 WBPaper00041895 WormAtlas

WBGene00002030
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
fat content reduced

"Animals exhibit less fat or lipid than observed in control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712]
RNAi: WBRNAi00023461   WBPaper00005655   Observed


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