JCEG ID JCEG155
Name R12E2.13      WormBase    NCBI Gene
Human Ortholog

GGDB:POMT2 

OMIM: 602934 607551

OrthoList :   SDF2   SDF2L1  (Ensembl Compara)

GGDB Score E-val
POMT2 59 8e-11
POMT1 42 7e-06
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name POMT
Locus Tag R12E2.13
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features gg_motif:M1, M3, M5
Sequence CDS
Protein
References

Hamamichi S, Rivas RN, Knight AL, Cao S, Caldwell KA, Caldwell GA Proc. Natl. Acad. Sci. U.S.A. (2008) 105 (2) :728-33 [PMID : 18182484] Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model.

WormBase (WS254)

Functional Descriptions R12E2.13

none available
Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0004292

anal depressor muscle "a single, H-shaped cell which lies just above the anus and connects the roof of the anal canal to the dorsal bodywall; its contractions act to increase the size of the anal opening by lifting the roof of the rectum and hence facilitate expulsion of intestinal contents." [ISBN:0-87969-307-X, WBPaper:00038216] WB:Expr6516 WBPaper00006525 WormAtlas
WB WBbt:0004506

gon_herm_dtc_P "Posterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad" [ISBN:0-87969-307-X] WB:Expr6516 WBPaper00006525
WB WBbt:0004520

gon_herm_dtc_A "Anterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad" [ISBN:0-87969-307-X] WB:Expr6516 WBPaper00006525
WB WBbt:0005735

nervous system "Complement of nervous tissue (neurones, nerves, receptors and support cells) serving to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities." [ISBN:0-14-051288-8, WB:rynl] WB:Expr6516 WBPaper00006525 WormAtlas
WB WBbt:0005747

reproductive system WB:Expr6516 WBPaper00006525
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] WB:Expr6516 WBPaper00006525 WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00026980 : intestine_enriched
WBPaper00026980 WormAtlas
WB WBbt:0005799

rectal gland cell WB:Expr6516 WBPaper00006525 WormAtlas
WB WBbt:0005813

body wall musculature "Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] WB:Expr6516 WBPaper00006525 WormAtlas
WB WBbt:0005828

gonadal sheath cell "five pairs of thin gonadal sheath cells form a single layer covering the germ line component of each arm, each pair occupying a stereotyped position along the gonad proximal-distal axis." [WBPaper:00038216] WB:Expr6516 WBPaper00006525 WormAtlas
WB WBbt:0006748

vulva "female genital." [WB:rynl] WB:Expr6516 WBPaper00006525 WormAtlas
WB WBbt:0006751

head neuron "neuron with its cell body situated in the head, excluding the pharynx." [WB:rynl] WB:Expr6516 WBPaper00006525
WB WBbt:0006760

uterus "The organ in which the eggs are developed and protected until laid." [ISBN:0198611862, WB:rynl] WB:Expr6516 WBPaper00006525 WormAtlas

WBGene00020038
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
protein aggregation variant

"Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
RNAi: WBRNAi00076614   WBPaper00031384   Observed
transgene subcellular localization variant

"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
RNAi: WBRNAi00076614   WBPaper00031384   Observed


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