JCEG ID |
JCEG155 |
Name |
R12E2.13
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:POMT2
OMIM:
602934
607551
OrthoList :
SDF2
SDF2L1
(Ensembl Compara)
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
POMT |
Locus Tag |
R12E2.13
|
RNAi phenotype |
phenotype
|
WT
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
gg_motif:M1, M3, M5
|
Sequence |
CDS
atgccgaaattgccactactactcagttttccacttctattcttcgcctc atttgcatacgccgatgaagactttgtgacgtgctacagcgttttaaagt ttataaatgctaatgatggctctaggttacattcgcatgacgtaaaatac ggaagcgggtccggccaacaatctgtgactgctgtaaaaaactcggacga catcaattctcattggcagattttcccagctttgaacgcaaaatgcaatc gtggagatgcaatcaaatgcggagacaagatccgtctgaagcacctcacc acgggcacgttcctgcattcccatcatttcactgcacctctctccaaaca acatcaggaggtctccgcttttggcagcgaagcagaaagtgacacgggag atgattggactgtgatttgcaacggagatgagtggttggaatccgagcaa ttcaaacttcgccacgctgtcactggttcatacctctcactctcgggaca acaattcggacgccccattcatggacaacgggaggtcgtcggcaccgact cgatcactggtggaagtgcatggaaagttgccgaaggcatttacatcaag catcagcaaaaagatctttaa
|
Protein
MPKLPLLLSFPLLFFASFAYADEDFVTCYSVLKFINANDGSRLHSHDVKYGSGSGQQSVT AVKNSDDINSHWQIFPALNAKCNRGDAIKCGDKIRLKHLTTGTFLHSHHFTAPLSKQHQE VSAFGSEAESDTGDDWTVICNGDEWLESEQFKLRHAVTGSYLSLSGQQFGRPIHGQREVV GTDSITGGSAWKVAEGIYIKHQQKDL
|
References |
Hamamichi S, Rivas RN, Knight AL, Cao S, Caldwell KA, Caldwell GA
Proc. Natl. Acad. Sci. U.S.A.
(2008)
105
(2)
:728-33
[PMID : 18182484]
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model.
|
Functional Descriptions |
R12E2.13
none available
|
Deletion Mutants |
|
In Situ |
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0004292
|
anal depressor muscle |
"a single, H-shaped cell which lies just above the anus and connects the roof of the anal canal to the dorsal bodywall; its contractions act to increase the size of the anal opening by lifting the roof of the rectum and hence facilitate expulsion of intestinal contents." [ISBN:0-87969-307-X, WBPaper:00038216] |
|
WB:Expr6516
|
WBPaper00006525
|
WormAtlas
|
WB |
WBbt:0004506
|
gon_herm_dtc_P |
"Posterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad" [ISBN:0-87969-307-X] |
|
WB:Expr6516
|
WBPaper00006525
|
|
WB |
WBbt:0004520
|
gon_herm_dtc_A |
"Anterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad" [ISBN:0-87969-307-X] |
|
WB:Expr6516
|
WBPaper00006525
|
|
WB |
WBbt:0005735
|
nervous system |
"Complement of nervous tissue (neurones, nerves, receptors and support cells) serving to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities." [ISBN:0-14-051288-8, WB:rynl] |
|
WB:Expr6516
|
WBPaper00006525
|
WormAtlas
|
WB |
WBbt:0005747
|
reproductive system |
|
|
WB:Expr6516
|
WBPaper00006525
|
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
|
WB:Expr6516
|
WBPaper00006525
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00026980 : intestine_enriched
|
WBPaper00026980
|
WormAtlas
|
WB |
WBbt:0005799
|
rectal gland cell |
|
|
WB:Expr6516
|
WBPaper00006525
|
WormAtlas
|
WB |
WBbt:0005813
|
body wall musculature |
"Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] |
|
WB:Expr6516
|
WBPaper00006525
|
WormAtlas
|
WB |
WBbt:0005828
|
gonadal sheath cell |
"five pairs of thin gonadal sheath cells form a single layer covering the germ line component of each arm, each pair occupying a stereotyped position along the gonad proximal-distal axis." [WBPaper:00038216] |
|
WB:Expr6516
|
WBPaper00006525
|
WormAtlas
|
WB |
WBbt:0006748
|
vulva |
"female genital." [WB:rynl] |
|
WB:Expr6516
|
WBPaper00006525
|
WormAtlas
|
WB |
WBbt:0006751
|
head neuron |
"neuron with its cell body situated in the head, excluding the pharynx." [WB:rynl] |
|
WB:Expr6516
|
WBPaper00006525
|
|
WB |
WBbt:0006760
|
uterus |
"The organ in which the eggs are developed and protected until laid." [ISBN:0198611862, WB:rynl] |
|
WB:Expr6516
|
WBPaper00006525
|
WormAtlas
|
|
WBGene00020038
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
protein aggregation variant
|
"Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
transgene subcellular localization variant
|
"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|