JCEG ID JCEG154
Name Y73B3A.3      WormBase    NCBI Gene
Human Ortholog

GGDB:POMGNT1 

OMIM: 300492 608617 608618 608619

OrthoList :   FAM3C   FAM3A   FAM3D   FAM3B  (Ensembl Compara)

GGDB Score E-val
POMGNT1 67 1e-12
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name POMGnT
Locus Tag Y73B3A.3
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Simmer F, Moorman C, van der Linden AM, Kuijk E, van den Berghe PV, Kamath RS, Fraser AG, Ahringer J, Plasterk RH PLoS Biol. (2003) 1 (1) :E12 [PMID : 14551910] Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.

Norman KR, Cordes S, Qadota H, Rahmani P, Moerman DG Dev. Biol. (2007) 309 (1) :45-55 [PMID : 17662976] UNC-97/PINCH is involved in the assembly of integrin cell adhesion complexes in Caenorhabditis elegans body wall muscle.

Lockwood CA, Lynch AM, Hardin J J. Cell. Sci. (2008) 121 (Pt 9) :1477-87 [PMID : 18411252] Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.

WormBase (WS254)

Functional Descriptions Y73B3A.3

none available
Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0006819

AVE "Neuron class of two interneurons with cell bodies situated in the lateral ganglion close to the ring neuropile." [WB:Paper00000938] Enriched WBPaper00037950 : AVE-neuron_embryo_enriched
 WBPaper00037950

WBGene00022205
Phenotype
Homology_paralog
Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
body elongation variant

"Any variation in the elongation of embryonic epidermal cells compared to control. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm." [WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00077691   WBPaper00031697   Observed
embryonic lethal

"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
RNAi: WBRNAi00025064   WBPaper00006395   Observed
multiple cytoplasmic cavities early emb

"Multiple vesicles, vacuoles, or cavities are seen during early embryogenesis." [cgc:5599, WB:cab]
RNAi: WBRNAi00077691   WBPaper00031697   Observed
paralyzed arrested elongation two fold

"Movement and elongation ceases at the two-fold stage. The myofilament lattice in body wall muscle cells is variant. However, development in embryos continues. Embryos hatch as inviable larvae." [WB:cab, WB:cgc1894]
RNAi: WBRNAi00066129   WBPaper00030886   Observed
protein subcellular localization variant

"Any variation in the placement of a protein within in a cell or cellular compartment compared to control." [WB:WBPerson557]
RNAi: WBRNAi00077692   WBPaper00031697   Observed
slow growth

"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
RNAi: WBRNAi00025064   WBPaper00006395   Observed


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