JCEG ID JCEG152
Name C15C7.7      WormBase    NCBI Gene
Human Ortholog

GGDB:POFUT1 

OMIM: 607491 615327

OrthoList :   POFUT1  (Ensembl Compara)

GGDB Score E-val
POFUT1 271 1e-74
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name POFUT
Locus Tag C15C7.7
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features kr:Detected
tm:Detected
gg_motif:M1,M2,M3,M4,M5,M6
Sequence CDS
Protein
References

Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK Mol. Biol. Cell (2005) 16 (9) :4202-13 [PMID : 15987734] The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.

Kozma K, Keusch JJ, Hegemann B, Luther KB, Klein D, Hess D, Haltiwanger RS, Hofsteenge J J. Biol. Chem. (2006) 281 (48) :36742-51 [PMID : 17032646] Identification and characterization of abeta1,3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeats.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Lira-Navarrete E, Valero-Gonzalez J, Villanueva R, Martinez-Julvez M, Tejero T, Merino P, Panjikar S, Hurtado-Guerrero R PLoS One (2011) 6 (9) :e25365 [PMID : 21966509] Structural insights into the mechanism of protein O-fucosylation.

WormBase (WS254)

Functional Descriptions C15C7.7

C15C7.7 encodes a protein O-fucosyltransferase orthologous to the vertebrate POFUT1 family of proteins; the protein product of C15C7.7 exhibits protein O-fucosyltransferase activity in vitro, fucosylating the EGF12 repeat from the mouse Notch1 receptor; by sequence similarity, the product of C15C7.7 is predicted to localize to the endoplasmic reticulum.
Deletion Mutants
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00030839 : Embryo_Pan_Neuronal
WBPaper00030839 WormAtlas
WB WBbt:0005751

coelomocyte "A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] Enriched WBPaper00037950 : coelomocytes_embryo_SelectivelyEnriched, coelomocytes_embryo_enriched
WBPaper00037950 WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00037950 : intestine_larva_SelectivelyEnriched, intestine_larva_enriched
WBPaper00037950 WormAtlas

WBGene00015793
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele


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