JCEG ID JCEG151
Name pps-1      WormBase
Human Ortholog

GGDB:PAPSS1 PAPSS2 

OMIM: 603005 603262 612847

OrthoList :   PAPSS2   PAPSS1  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
MAPPED 0.000004 1.32 [1.17-1.49] 19727025
DOWNSTREAM 0.000002 (EA) 0.02742 (0.01614-0.03871) (mg/dl increase)] 25886283
DOWNSTREAM 0.0000004 0.0243 (mg/dl increase) [NR] 25886283
DOWNSTREAM 0.029 0.00000005 [NR] 24478790
Family Name PAPS synthase and PAPS transporters
Locus Tag T14G10.1
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Dejima K, Seko A, Yamashita K, Gengyo-Ando K, Mitani S, Izumikawa T, Kitagawa H, Sugahara K, Mizuguchi S, Nomura K J. Biol. Chem. (2006) 281 (16) :11431-40 [PMID : 16497669] Essential roles of 3'-phosphoadenosine 5'-phosphosulfate synthase in embryonic and larval development of the nematode Caenorhabditis elegans.

Samuelson AV, Carr CE, Ruvkun G Genes Dev. (2007) 21 (22) :2976-94 [PMID : 18006689] Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.

Ruzanov P, Jones SJ, Riddle DL BMC Genomics (2007) 8 :447 [PMID : 18053145] Discovery of novel alternatively spliced C. elegans transcripts by computational analysis of SAGE data.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

van den Boom J, Heider D, Martin SR, Pastore A, Mueller JW J. Biol. Chem. (2012) 287 (21) :17645-55 [PMID : 22451673] 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) synthases, naturally fragile enzymes specifically stabilized by nucleotide binding.

WormBase (WS254)

Functional Descriptions pps-1

pps-1 is orthologous to human PAPSS1 (OMIM:603262) and human PAPSS2 (OMIM:603005, mutated in spondyloepimetaphyseal dysplasia).
Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00030839 : Larval_Pan_Neuronal
WBPaper00030839 WormAtlas
WB WBbt:0003933

AMshR "Embryonic cell of pedigree ABpraapaapp, amphid sheath cell, right." [ISBN:0-87969-307-X] Certain WB:Expr4395|WB:Expr4396 WBPaper00027123 WormAtlas
WB WBbt:0003935

AMshL "Embryonic cell of pedigree ABplaapaapp, amphid sheath cell, left." [ISBN:0-87969-307-X] Certain WB:Expr4395|WB:Expr4396 WBPaper00027123 WormAtlas
WB WBbt:0004679

hyp6 "Cylindrical hypodermal syncytium in head" [ISBN:0-87969-307-X] Certain WB:Expr4396 WBPaper00027123
WB WBbt:0004687

hyp4 "Cylindrical hypodermal syncytium in head" [ISBN:0-87969-307-X] Certain WB:Expr4396 WBPaper00027123
WB WBbt:0005734

hyp7 syncytium "entire syncytium of hyp7" [WB:pws] Certain WB:Expr4396 WBPaper00027123
WB WBbt:0005735

nervous system "Complement of nervous tissue (neurones, nerves, receptors and support cells) serving to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities." [ISBN:0-14-051288-8, WB:rynl] WB:Expr6696 WBPaper00006525 WormAtlas
WB WBbt:0005753

seam cell "a group of hypodermal cells that lie along the apical midline of the hypodermis, at the extreme left and right sides between nose and tail" [WB:rynl, WBPaper:00038216] Certain WB:Expr4395|WB:Expr4396 WBPaper00027123 WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00026980 : intestine_enriched
WBPaper00026980 WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Certain WB:Expr4395|WB:Expr4396 WBPaper00027123 WormAtlas
WB WBbt:0005788

pharyngeal gland cell "secretory gland cell of the pharynx" [WB:rynl] Certain WB:Expr4395|WB:Expr4396 WBPaper00027123 WormAtlas
WB WBbt:0006751

head neuron "neuron with its cell body situated in the head, excluding the pharynx." [WB:rynl] WB:Expr6696 WBPaper00006525

WBGene00004091
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
shortened life span

"The duration of viability in the adult phase of the life-cycle is less than that of control animals." [GO:0008340, WB:WBPerson712]
RNAi: WBRNAi00070596   WBPaper00031212   Observed


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