JCEG ID JCEG140
Name ribo-1      WormBase
Human Ortholog

GGDB:RPN1 

OMIM: 180470

OrthoList :   RPN1  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.0000000000006 (Monocytes) 0.028 (unit decrease) [0.020-0.036] 21738480
DOWNSTREAM 0.0000000000004 (Basophils) 0.01 (unit increase) [0.0073-0.0127] 21738480
DOWNSTREAM 0.66 0.00000000000000003 (eosinophil count) 0.103 (unit increase) [0.08-0.12] 21738478
DOWNSTREAM 0.66 0.0000000000000000000000000000000000000005 (basophil count) 0.161 (unit increase) [0.14-0.18] 21738478
DOWNSTREAM 0.441 0.00000001 (EA) 0.028 (unit decrease) [0.018-0.038] 25096241
MAPPED 0.4 0.0000000000000002 0.23 (unit decrease)] 23314186
Family Name Oligosaccharyltransferase complex
Locus Tag T22D1.4
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G Nature (2003) 421 (6920) :268-72 [PMID : 12529643] Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.

Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, Le Bot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P, Ahringer J Nature (2003) 421 (6920) :231-7 [PMID : 12529635] Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.

Rual JF, Ceron J, Koreth J, Hao T, Nicot AS, Hirozane-Kishikawa T, Vandenhaute J, Orkin SH, Hill DE, van den Heuvel S, Vidal M Genome Res. (2004) 14 (10B) :2162-8 [PMID : 15489339] Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library.

Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK Mol. Biol. Cell (2005) 16 (9) :4202-13 [PMID : 15987734] The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.

Sonnichsen B, Koski LB, Walsh A, Marschall P, Neumann B, Brehm M, Alleaume AM, Artelt J, Bettencourt P, Cassin E, Hewitson M, Holz C, Khan M, Lazik S, Martin C, Nitzsche B, Ruer M, Stamford J, Winzi M, Heinkel R, Roder M, Finell J, Hantsch H, Jones SJ, Jones M, Piano F, Gunsalus KC, Oegema K, Gonczy P, Coulson A, Hyman AA, Echeverri CJ Nature (2005) 434 (7032) :462-9 [PMID : 15791247] Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans.

Gottschalk A, Almedom RB, Schedletzky T, Anderson SD, Yates JR, Schafer WR EMBO J. (2005) 24 (14) :2566-78 [PMID : 15990870] Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K Cell (2011) 145 (3) :470-82 [PMID : 21529718] A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

LeGendre JB, Campbell ZT, Kroll-Conner P, Anderson P, Kimble J, Wickens M J. Biol. Chem. (2012) 288 (4) :2532-45 [PMID : 23195953] RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans.

[PMID : 23691084]

WormBase (WS254)

Functional Descriptions ribo-1

Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0005662

AFD "Neuron class of two ciliated neurons that are part of the amphid sensillum; the endings of AFD have numerous villi, which poke into the amphid sheath cells." [WB:Paper00000938] Enriched WBPaper00024671 : AFD_AWB_vs_unsorted_upregulated
WBPaper00024671
WB WBbt:0005671

AWB "Neuron class of two ciliated neurons with flattened, sheet-like endings that are associated with the sheath cells of the amphid sensilla" [WB:Paper00000938] Enriched WBPaper00024671 : AFD_AWB_vs_unsorted_upregulated
WBPaper00024671

WBGene00020683
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
cell membrane organization biogenesis variant

"Variations in the process(es) involved in the assembly, transport, arrangement or disassembly of cell membrane structures or components compared to control." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085764   WBPaper00038381   Observed
clear

"Animals appear unusually transparent when compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654]
RNAi: WBRNAi00009208   WBPaper00005654   Observed
cytokinesis variant emb

"Any variation that disrupts the cytoplasmic division of a cell during embryonic development compared to control." [GO:0000910, WB:WBPerson2021]
RNAi: WBRNAi00061133   WBPaper00026630   Observed
diakinesis progression during oogenesis variant

"Developing oocytes show defects in their entry, progression through or exit from the diakinesis stage compared to control animals. Diakinesis is a cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [GO:0000241, WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085764   WBPaper00038381   Observed
diplotene region organization variant

"Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diplotene stage. In C. elegans the diplotene region follows the pachytene region and occurs just distal to, and coincident with, the loop in the gonad arm. In the diplotene region germ cell compartments become organized into a single file." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085764   WBPaper00038381   Observed
embryo osmotic integrity defective early emb

"Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing." [WB:cab, WB:cgc7141]
RNAi: WBRNAi00053827   WBPaper00025054   Observed
embryonic lethal

"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
RNAi: WBRNAi00009208   WBPaper00005654   Observed
RNAi: WBRNAi00053827   WBPaper00025054   Observed
fat content reduced

"Animals exhibit less fat or lipid than observed in control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712]
RNAi: WBRNAi00023611   WBPaper00005655   Observed
germ cell compartment expansion variant

"Animals exhibit variations in the increase in size of compartments of the germline. In the C. elegans germline, syncytial compartments enlarge just prior to and coincident with the loop region, eventually abscising, to become fully enclosed germ cells (oocytes)." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085764   WBPaper00038381   Observed
germ cell compartment morphology variant

"Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis). These compartments eventually undergo cellularization and become oocytes." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085764   WBPaper00038381   Observed
germline nuclear positioning variant

"Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085764   WBPaper00038381   Observed
larval arrest

"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
RNAi: WBRNAi00033518   WBPaper00024497   Observed
locomotion variant

"Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712]
RNAi: WBRNAi00066747   WBPaper00026635   Observed
long

"Animals are longer than control animals at the same developmental stage." [WB:cab, WB:cgc31]
RNAi: WBRNAi00009208   WBPaper00005654   Observed
maternal sterile

" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
RNAi: WBRNAi00033518   WBPaper00024497   Observed
multiple nuclei early emb

"Embryos contain more than one nucleus per cell in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599]
RNAi: WBRNAi00061133   WBPaper00026630   Observed
nicotine hypersensitive

"Animals respond to nicotine at lower concentrations or shorter exposure compared to control. Nicotine is a cholinergic agonist." [WB:cab, WB:cgc7388, WB:WBPerson557]
RNAi: WBRNAi00066561   WBPaper00026635   Observed
slow growth

"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
RNAi: WBRNAi00009208   WBPaper00005654   Observed
small

"Animals are shorter and thinner than control animals at the same developmental stage." [WB:cab, WB:cgc31]
RNAi: WBRNAi00066747   WBPaper00026635   Observed
sterile

"Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712]
RNAi: WBRNAi00085764   WBPaper00038381   Observed


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