JCEG ID |
JCEG115 |
Name |
galt-1
WormBase
NCBI Gene
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Human Ortholog |
OMIM:
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Family Name |
Glyco_transf_92 |
Locus Tag |
M03F8.4
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RNAi phenotype |
phenotype
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Microscope observation (Image)
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COPAS (Image)
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hsp-4::GFP (Image)
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Sequence Features |
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Sequence |
CDS
ATGCCTCGAATCACCGCCAGTAAAATAGTTCTTCTAATTGCATTATCATTTTGTATTACTGTTATTTATC ACTTTCCAATAGCAACGAGAAGCAGTAAGGAGTACGATGAATATGGAAATGAATATGAAAACGTTGCATC GATAGAGTCGGATATAAAAAATGTACGTCGATTACTTGACGAGGTACCGGATCCCTCACAAAACCGTCTA CAATTCCTGAAACTTGATGAGCATGCTTTTGCATTCTCGGCCTACACAGACGATCGAAATGGAAATATGG GGTACAAATATGTCCGAGTCCTGATGTTTATCACGTCACAAGACAACTTTTCCTGTGAAATAAACGGGAG AAAGTCCACAGATGTATCACTTTACGAGTTCTCGGAAAATCACAAAATGAAGTGGCAAATGTTTATTTTG AATTGTAAACTACCCGATGGTATAGATTTCAATAATGTTAGCTCTGTAAAGGTCATAAGAAGCACAACCA AGCAGTTTGTTGATGTGCCGATTCGGTATAGAATTCAAGATGAGAAAATAATTACGCCAGACGAATATGA CTATAAAATGTCAATTTGTGTTCCAGCATTGTTTGGAAATGGATATGATGCAAAGCGAATTGTTGAGTTT ATTGAGCTGAATACTTTGCAAGGAATCGAGAAAATATACATTTACACTAATCAAAAAGAGCTTGATGGAT CCATGAAGAAAACGTTGAAATACTATTCGGATAATCACAAAATAACATTAATTGATTACACATTACCATT CAGAGAGGATGGTGTTTGGTATCACGGGCAATTGGCAACTGTTACTGATTGTTTACTGAGAAACACTGGA ATCACAAAATACACATTTTTCAATGATTTTGATGAGTTCTTCGTCCCCGTTATCAAAAGTCGGACTCTCT TTGAAACAATCAGTGGGCTTTTTGAAGATCCCACTATTGGATCGCAACGAACAGCTTTGAAGTATATAAA TGCAAAAATCAAGAGCGCTCCGTATTCACTGAAAAATATTGTTTCCGAAAAACGAATTGAAACAAGATTC ACGAAATGTGTAGTTCGACCGGAAATGGTTTTTGAACAGGGTATTCATCATACGAGTAGAGTGATTCAAG ACAACTATAAAACGGTTTCCCATGGCGGATCCCTTCTACGGGTTTATCATTACAAGGATAAAAAGTATTG TTGCGAAGACGAGAGCCTCTTGAAAAAACGGCATGGAGATCAACTTCGGGAAAAATTCGATTCAGTTGTT GGTCTTTTAGACTTGTAG
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Protein
MPRITASKIVLLIALSFCITVIYHFPIATRSSKEYDEYGNEYENVASIESDIKNVRRLLDEVPDPSQNRL QFLKLDEHAFAFSAYTDDRNGNMGYKYVRVLMFITSQDNFSCEINGRKSTDVSLYEFSENHKMKWQMFIL NCKLPDGIDFNNVSSVKVIRSTTKQFVDVPIRYRIQDEKIITPDEYDYKMSICVPALFGNGYDAKRIVEF IELNTLQGIEKIYIYTNQKELDGSMKKTLKYYSDNHKITLIDYTLPFREDGVWYHGQLATVTDCLLRNTG ITKYTFFNDFDEFFVPVIKSRTLFETISGLFEDPTIGSQRTALKYINAKIKSAPYSLKNIVSEKRIETRF TKCVVRPEMVFEQGIHHTSRVIQDNYKTVSHGGSLLRVYHYKDKKYCCEDESLLKKRHGDQLREKFDSVV GLLDL
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References |
Titz A, Butschi A, Henrissat B, Fan YY, Hennet T, Razzazi-Fazeli E, Hengartner MO, Wilson IB, Kunzler M, Aebi M
J. Biol. Chem.
(2009)
284
(52)
:36223-33
[PMID : 19858195]
Molecular basis for galactosylation of core fucose residues in invertebrates: identification of caenorhabditis elegans N-glycan core alpha1,6-fucoside beta1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family.
Butschi A, Titz A, Walti MA, Olieric V, Paschinger K, Nobauer K, Guo X, Seeberger PH, Wilson IB, Aebi M, Hengartner MO, Kunzler M
PLoS Pathog.
(2010)
6
(1)
:e1000717
[PMID : 20062796]
Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.
Maduzia LL, Yu E, Zhang Y
J. Biol. Chem.
(2010)
286
(6)
:4371-81
[PMID : 21115491]
Caenorhabditis elegans galectins LEC-6 and LEC-10 interact with similar glycoconjugates in the intestine.
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Functional Descriptions |
galt-1
galt-1 encodes a galactosyltransferase that is a member of a novel glycosyltransferase family of proteins found in a wide variety of multicellular eukaryotes, but not in mammals; when expressed in insect calls, GALT-1 demonstrates manganese-dependent galactosyltransferase activity; loss of galt-1 activity results in animals that are resistant to the toxic effects of the fungal galectin CGL2 from the ink cap mushroom Coprinopsis cinerea.
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Deletion Mutants |
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In Situ |
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Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0005751
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coelomocyte |
"A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] |
Enriched |
WBPaper00037950 : coelomocytes_embryo_SelectivelyEnriched, coelomocytes_embryo_enriched
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WBPaper00037950
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WormAtlas
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WB |
WBbt:0005772
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intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00037950 : intestine_larva_SelectivelyEnriched, intestine_larva_enriched
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WBPaper00037950
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WormAtlas
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WBGene00019763
Phenotype
Homology_paralog
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Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
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"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
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larval arrest
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"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
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larval lethal
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"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
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lethal
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"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
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maternal sterile
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" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
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organism morphology variant
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"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
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postembryonic development variant
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"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
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slow growth
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"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
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sterile progeny
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"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
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Variant
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"Animals exhibit variations compared to a given control." [WB:WBPerson557]
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