JCEG ID |
JCEG086 |
Name |
M70.4
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:POMGNT1
OMIM:
300492
608617
608618
608619
OrthoList :
FAM3C
FAM3A
FAM3D
FAM3B
(Ensembl Compara)
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
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Family Name |
GlcNAcT(GnT) |
Locus Tag |
M70.4
|
RNAi phenotype |
phenotype
|
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Microscope observation (Image)
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COPAS (Image)
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Normal
|
hsp-4::GFP (Image)
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|
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Sequence Features |
kr:Detected
tm:Detected
dxd:EED
gg_motif:M3, M4, M5
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Sequence |
CDS
atgataaaggtgaattggaggcttctcctattattaccactactactcac cacatttttaatattcaaatttgccacattggatggtgataataatcccg aaattgcaaatattggtggcgaaaaatcaattattggaggtatcgggaaa ccgaagagtttggtggatcaggtccaagaagagggtggagcttcaagtga atccaaatgctactacgacaatcagtgcaccctaccgcaaatgctcttcc gagtacgcagcgaaacggatagtcagcctccatttgcgtgtctcaacgat attaagctattcgacacggataacattggccgcggaataaatgcggccat tttgaacggaacaaccggtgatatcatcgaaaaagccacgtttgacgtca cggcgtccgatgagaaattgatgacgtggcttttaaaagtgccccacgcc tcgctgctcgttgccgcctcatttggtgacgtggcagagcacgtctcccg acaatcccgccaattgttcgccgctttcggagctcaaaaaatcgataatt ggagggtgggaaacgcctacgcaattatcggacaacgtggaatccgccgg ggagaagcccacgaaactgtcgccaagtttttggaagaaaacacgcagca aaagctctttgaagggtgttttgatctaccgattgctgaaattggtggag aagttgaactgaaaatcgatgggccgccggtgcatagagccgacgaatca aagctcgcggagctcggagcattcgaggcggacttgctccaacaaaacaa ggacgtcgagtatggcggaaaatggaagaattgcggaatggaccgcccgt gtaacgaggccgacacaattcccgtccactttttctccggcgagcacaag gatgatcatccgaaaatgtgcattggtgggcggatgctttttgataaaga cctcaactctgccggccgtgggcttaacctggcgatgttggagcctaaaa ctgggaaagttactgcagttgcacattttgacacttatgaggatgaatcc cacggcttggaagaatggcttgacgcggtgccgaccggctacattgtagc cgttgtgagcttcgacgaggcctctaatcagctgtcagatatggctcggc gcatcttttacgagatgggctccagtatgatcgatcggctcaaattccga gcttcgtggtatttcgtcggacagaagggcatcggcgcctacacaccgtt tgaagacctgaatattccacagggaaataactgggcaaatccgattcata cctcattttgtttgccgaaatctttgcacaaatgggcgggccgccgggac acatcatcatcgatgacgtcatcagcttcaaatgacgtcagaaatttgcc gaaacgacatttctgcgcaaaatatgaccgacatgaagagttttgtggtg ccgccaaccttgactctccaataatgccacgtcacctcagcgacgaacaa cgctcgtcggacgcgattttcaacgtaccgatccttgtcgcgtcgggttt ggcaccggattctttgagaattacactggaatcattgcttaatcaggagg gtctgaatacccaaatggttctagtcacttatgataaggaatactcggaa aatgcggatttggtgtcgctttttcatgtgaaaagtgtggcgattcagtc gaatggcagttataatgcccatcttctgttgtcgctgtcgaatgcttttt ccatttttccggatgcctcttcggtgttggttattgaagaagacgtgaca ctatcaaccgattggcttcactatttctcatcaatttatgagccgtacaa ggcggattccactgtggacttggcgctggcttttaactcaaatggcttca tcgacacttctggcgatggtcaaacggtgtatcgcatcaaaaatcatctt ccaattggatcgtatttaatgaagagagatttgtacgaaaaacatattcg gttgagagaattctgctgtacggaacgtggcaattgggatctccgtgaat cgatttctctagtgccggcaatgtcacgtattgaaattcaagttgacgag ctggaaaagaaaaatgttctttttcggcggaatcgcaccgcgacacaaca aaactacctaatcaatacggaattcgagacttctgaagaatatttgacac atttgaaccaacttgttcagaatacgaaaaaatcgataccgatcaccgaa atccaatcgattggatgcgaagcgtgggcagatcaactggatcggcaact aaaatcgatattattaacatattctgcaaaatcagaagtcgaatcgattt tcgagtgttggaaaatgtattggacaccgaaaattctcagaagtaaccgc gtctttagattctcccttcatcaagccatcgaggtcatcattgttgccga taatcttaaaattaaatga
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Protein
MIKVNWRLLLLLPLLLTTFLIFKFATLDGDNNPEIANIGGEKSIIGGIGKPKSLVDQVQE EGGASSESKCYYDNQCTLPQMLFRVRSETDSQPPFACLNDIKLFDTDNIGRGINAAILNG TTGDIIEKATFDVTASDEKLMTWLLKVPHASLLVAASFGDVAEHVSRQSRQLFAAFGAQK IDNWRVGNAYAIIGQRGIRRGEAHETVAKFLEENTQQKLFEGCFDLPIAEIGGEVELKID GPPVHRADESKLAELGAFEADLLQQNKDVEYGGKWKNCGMDRPCNEADTIPVHFFSGEHK DDHPKMCIGGRMLFDKDLNSAGRGLNLAMLEPKTGKVTAVAHFDTYEDESHGLEEWLDAV PTGYIVAVVSFDEASNQLSDMARRIFYEMGSSMIDRLKFRASWYFVGQKGIGAYTPFEDL NIPQGNNWANPIHTSFCLPKSLHKWAGRRDTSSSMTSSASNDVRNLPKRHFCAKYDRHEE FCGAANLDSPIMPRHLSDEQRSSDAIFNVPILVASGLAPDSLRITLESLLNQEGLNTQMV LVTYDKEYSENADLVSLFHVKSVAIQSNGSYNAHLLLSLSNAFSIFPDASSVLVIEEDVT LSTDWLHYFSSIYEPYKADSTVDLALAFNSNGFIDTSGDGQTVYRIKNHLPIGSYLMKRD LYEKHIRLREFCCTERGNWDLRESISLVPAMSRIEIQVDELEKKNVLFRRNRTATQQNYL INTEFETSEEYLTHLNQLVQNTKKSIPITEIQSIGCEAWADQLDRQLKSILLTYSAKSEV ESIFECWKMYWTPKILRSNRVFRFSLHQAIEVIIVADNLKIK
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References |
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Functional Descriptions |
M70.4
M70.4 is orthologous to human O-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE (FLJ20277; OMIM:606822), which when mutated leads to muscle-eye-brain disease.
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Deletion Mutants |
|
In Situ |
In Situ
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0004740
|
I5 neuron |
"Neuron class of one pharyngeal interneuron, posterior sensory." [ISBN:0-87969-307-X] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
|
WB |
WBbt:0005278
|
DA neuron |
"Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
|
WB |
WBbt:0005278
|
DA neuron |
"Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] |
Enriched |
WBPaper00030839 : Embryo_A_Class
|
WBPaper00030839
|
|
WB |
WBbt:0005396
|
SAB |
"Neuron class of three interneurons, which send processes anteriorly up the sub-lateral cords in the head." [WB:Paper00000938] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
|
WB |
WBbt:0005656
|
retrovesicular ganglion |
"ganglion that lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore. It is open and continuous with the region containing the motoneurons of the ventral cord. In the early L1 this ganglion holds 12 neuron cell bodies plus one neuroblast (Sulston and Horvitz, 1977; White et al., 1986). In the adult animal, the ganglion holds 20 neuron cell bodies.\nReversal \n\n" [WBPaper:00038216] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
WormAtlas
|
|
WBGene00019786
Phenotype
Homology_paralog
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Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
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larval arrest
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"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
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larval lethal
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"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
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lethal
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"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
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maternal sterile
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" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
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organism morphology variant
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"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
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postembryonic development variant
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"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
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slow growth
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"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
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sterile progeny
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"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
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Variant
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"Animals exhibit variations compared to a given control." [WB:WBPerson557]
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