JCEG ID | JCEG080 | ||||||||
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Name | dpm-3 WormBase | ||||||||
Human Ortholog |
GGDB:DPM3 OMIM: OrthoList :
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Family Name | GPI-anchor synthesis | ||||||||
Locus Tag | F28D1.11 | ||||||||
RNAi phenotype |
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Sequence Features | |||||||||
Sequence | CDS |
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Protein |
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References |
Maeda I, Kohara Y, Yamamoto M, Sugimoto A Curr. Biol. (2001) 11 (3) :171-6 [PMID : 11231151] Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV PLoS Pathog. (2011) 7 (3) :e1001314 [PMID : 21408619] Global functional analyses of cellular responses to pore-forming toxins. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. |
Functional Descriptions |
dpm-3 dpm-3 encodes a putative regulatory subunit of dolichol phosphate mannosyltransferase, orthologous to human DPM3 (OMIM:605951); in mass RNAi assays, DPM-3 is required for normal body size, fertility, and health. |
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Deletion Mutants | ||||||||||||||||||
In Situ | ||||||||||||||||||
Expression |
Expression
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WBGene00009219 Phenotype Homology_paralog |
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Phenotype | Definition | RNAi / Allele | ||||||||||||||||
Bacillus thuringiensis toxin hypersensitive
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"Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] |
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pore forming toxin hypersensitive
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"Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557] |
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sick
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"Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712] |
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small
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"Animals are shorter and thinner than control animals at the same developmental stage." [WB:cab, WB:cgc31] |
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sterile progeny
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"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557] |
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