JCEG ID |
JCEG078 |
Name |
hpo-20
WormBase
|
Human Ortholog |
GGDB:PIGW
OMIM:
610275
OrthoList :
ENSG00000184886
(Ensembl Compara)
|
Family Name |
GPI-anchor synthesis |
Locus Tag |
Y110A2AL.12
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RNAi phenotype |
phenotype
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Microscope observation (Image)
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COPAS (Image)
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hsp-4::GFP (Image)
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Sequence Features |
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Sequence |
CDS
ATGAGCCAAGCCGATGTCGGAGCAACAACTGAGCACAGTTCATTCGTTGGAACACTGACAGGATGTGCTC AACGGGAGCTCTTTTTGACGTTCCTCATCACAATGTTGGGACTTTTTATACGGAATCTAACGTTGCCGTG GATTTTCTTAGGACGACGATATGATACCGGAAGATTCACCTACTGGCTAAAATTCGTTGCCGACGTCATA TTCCTCTGCGTTCCATCCCTTCTCGCAATGACAGTGCTCAACGAGCACCTCATCCTCCTCTCCACCATAA TGATCATCATCTCTGCAGTTTTGCTCATTTTTGTGCTCTTCGAAGCCGCCGAGCAACACCACAACCACCA TCAGCTCTCCGTGATTCTTCGACAATCGTGGAGTCGATTCGTCGAAGAACAGCATAAACCCACGCAATTT GTCACCTATTTCCGGTCCCTTACCATGATTTTGGTCACTCTCGCCATTTTGGCTGTGGATTTTCCGATTT TTCCGAGAAAATACGCAAAAACCGAGAAATTCGGACATTCGATGATGGATGTCGGAGTGGCGGCTTTCCT GTTTCAGGCGGCGCTAGGCAGCCGAATGGCAAAGTCGCCGAGCTCCGGACGACAACTTTCACACCATTCC CCCCGCCCGTGGTACCTCAGCTCCACATTTCTTCTATTTGCTCTCGGAGCCGGCCGTGCTGTGCTCCTCG AAGTGATTGGCTATCCGCAACACGTCACCGAATATGGCGTTCATTGGAACTTTTTCTTCACGATGGCCGC TATCAGGATCCTGTCCTCCTCAATTCTGCCACGCTGCTACCCTCTCGTTCTCTCTGTGATCTTTGGAATT TGCCATCAAACAATGCTCAAATCCACGGGGCTCCAGGCATGGATCCTTGACGAGTCGGCGAATCGCCGCG AGAATCTGATCACCGCCAACGCGGAGGGTCTGACGTCACTCATGGGATATTTGACGATATTCTACGCGAG TTTGGCCATCGGAGAGTTTATGGCGAAGACTAGCATCCGCATCAAATCGTGGATCCGCCGATGCTTCCAG CTCTTCGCACTCTCGCTGATCCTATTTTTTATTCAAATTGCCGCCGAAAAATGCGTTGACCCACCGTGTC GACGTGTGGTTAATGCCACGTATATCTTTTCACAGTTAACCCTCATGACCTTCGCCACCGGAGTCTGCCT ATCAATCCAAATGTTCAATACAGTCGCCTGGTGTTCCAGTTTCCCGCAGTTCTCAAATGGCGAAGATCCG TATTCCGTGGTGTCTCCGTGTCTTTCTGATTCTATAAATCGCCACTCACTGCTCTTTTTCCTCGTCTCAA ATGTGCTCACAGGCCTTGTCAACCTCTCGGTTGATGCTCATCGCCAGCCTCCGCACATTGCCTTCCCCAT TCTCTTGGCATATGTCACTGTGTGCACCGGTCTCATGCACTTTTTAGAATACCGGAAAATTAAATTTGCG ACGAGACCCCACGCCGAGTAG
ATGGCCGCTATCAGGATCCTGTCCTCCTCAATTCTGCCACGCTGCTACCCTCTCGTTCTCTCTGTGATCT TTGGAATTTGCCATCAAACAATGCTCAAATCCACGGGGCTCCAGGCATGGATCCTTGACGAGTCGGCGAA TCGCCGCGAGAATCTGATCACCGCCAACGCGGAGGGTCTGACGTCACTCATGGGATATTTGACGATATTC TACGCGAGTTTGGCCATCGGAGAGTTTATGGCGAAGACTAGCATCCGCATCAAATCGTGGATCCGCCGAT GCTTCCAGCTCTTCGCACTCTCGCTGATCCTATTTTTTATTCAAATTGCCGCCGAAAAATGCGTTGACCC ACCGTGTCGACGTGTGGTTAATGCCACGTATATCTTTTCACAGTTAACCCTCATGACCTTCGCCACCGGA GTCTGCCTATCAATCCAAATGTTCAATACAGTCGCCTGGTGTTCCAGTTTCCCGCAGTTCTCAAATGGCG AAGATCCGTATTCCGTGGTGTCTCCGTGTCTTTCTGATTCTATAAATCGCCACTCACTGCTCTTTTTCCT CGTCTCAAATGTGCTCACAGGCCTTGTCAACCTCTCGGTTGATGCTCATCGCCAGCCTCCGCACATTGCC TTCCCCATTCTCTTGGCATATGTCACTGTGTGCACCGGTCTCATGCACTTTTTAGAATACCGGAAAATTA AATTTGCGACGAGACCCCACGCCGAGTAG
|
Protein
MSQADVGATTEHSSFVGTLTGCAQRELFLTFLITMLGLFIRNLTLPWIFLGRRYDTGRFTYWLKFVADVI FLCVPSLLAMTVLNEHLILLSTIMIIISAVLLIFVLFEAAEQHHNHHQLSVILRQSWSRFVEEQHKPTQF VTYFRSLTMILVTLAILAVDFPIFPRKYAKTEKFGHSMMDVGVAAFLFQAALGSRMAKSPSSGRQLSHHS PRPWYLSSTFLLFALGAGRAVLLEVIGYPQHVTEYGVHWNFFFTMAAIRILSSSILPRCYPLVLSVIFGI CHQTMLKSTGLQAWILDESANRRENLITANAEGLTSLMGYLTIFYASLAIGEFMAKTSIRIKSWIRRCFQ LFALSLILFFIQIAAEKCVDPPCRRVVNATYIFSQLTLMTFATGVCLSIQMFNTVAWCSSFPQFSNGEDP YSVVSPCLSDSINRHSLLFFLVSNVLTGLVNLSVDAHRQPPHIAFPILLAYVTVCTGLMHFLEYRKIKFA TRPHAE
MAAIRILSSSILPRCYPLVLSVIFGICHQTMLKSTGLQAWILDESANRRENLITANAEGLTSLMGYLTIF YASLAIGEFMAKTSIRIKSWIRRCFQLFALSLILFFIQIAAEKCVDPPCRRVVNATYIFSQLTLMTFATG VCLSIQMFNTVAWCSSFPQFSNGEDPYSVVSPCLSDSINRHSLLFFLVSNVLTGLVNLSVDAHRQPPHIA FPILLAYVTVCTGLMHFLEYRKIKFATRPHAE
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References |
Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV
PLoS Pathog.
(2011)
7
(3)
:e1001314
[PMID : 21408619]
Global functional analyses of cellular responses to pore-forming toxins.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
hpo-20
|
Deletion Mutants |
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In Situ |
|
Expression |
Expression
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WBGene00022447
Phenotype
Homology_paralog
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Phenotype |
Definition |
RNAi / Allele |
Bacillus thuringiensis toxin hypersensitive
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"Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
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dauer lifespan extended
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"The life span of dauer-staged animals is longer than that observed in control dauer animals." [WB:WBPaper00032396, WB:WBPerson2987]
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embryonic lethal
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"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
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larval arrest
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"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
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larval lethal
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"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
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lethal
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"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
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maternal sterile
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" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
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organism morphology variant
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"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
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pore forming toxin hypersensitive
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"Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557]
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postembryonic development variant
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"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
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slow growth
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"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
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sterile progeny
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"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
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Variant
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"Animals exhibit variations compared to a given control." [WB:WBPerson557]
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