JCEG ID JCEG077
Name pigv-1      WormBase    NCBI Gene
Human Ortholog

GGDB:PIGV 

OMIM: 239300 610274

OrthoList :   PIGV  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
UPSTREAM 0.09 0.000000001 0.037 (mg/dL increase) [NR] 24097068
UPSTREAM 0.09 0.000000000003 0.05 (unit increase) [NR] 24097068
UPSTREAM 0.09 0.000000000000001 0.051 (unit decrease) [NR] 24097068
Family Name GPI-anchor synthesis
Locus Tag T09B4.1
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Hekimi S, Boutis P, Lakowski B Genetics (1995) 141 (4) :1351-64 [PMID : 8601479] Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans.

Ceron J, Rual JF, Chandra A, Dupuy D, Vidal M, van den Heuvel S BMC Dev. Biol. (2007) 7 :30 [PMID : 17417969] Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.

Wang J, Farr GW, Hall DH, Li F, Furtak K, Dreier L, Horwich AL PLoS Genet. (2009) 5 (1) :e1000350 [PMID : 19165329] An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

WormBase (WS254)

Functional Descriptions pigv-1

Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003681

pharynx "the feeding organ, a neuro-muscular pump in the head of the animal, used to ingest food, bacteria suspended in liquid, filter them out, grind them up and transport posteriorly into the instestine." [WB:rynl] Certain WB:Expr12350 WBPaper00046712 WormAtlas
WB WBbt:0004015

AB "Embryonic founder cell" [ISBN:0-87969-307-X] Enriched WBPaper00046691 : AB_enriched
WBPaper00046691
WB WBbt:0005733

hypodermis "epidermal layer" [WB:pws] Certain WB:Expr12350 WBPaper00046712
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Certain WB:Expr12350 WBPaper00046712 WormAtlas
WB WBbt:0005800

rectal epithelium "epithelium connecting intestine and anus." [WB:rynl] Certain WB:Expr12350 WBPaper00046712 WormAtlas
WB WBbt:0005812

excretory cell "H-shaped cell associated with the excretory system, largest cell in C. elegans." [WB:rynl] Certain WB:Expr12350 WBPaper00046712 WormAtlas
WB WBbt:0006849

germline precursor cell "member of a set of two cells that generate exclusively sperm and ovum." [WB:rynl] Enriched WBPaper00037950 : germline-precursors_embryo_SelectivelyEnriched, germline-precursors_embryo_enriched
WBPaper00037950

WBGene00020375
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
body morphology variant

"Animals exhibit variations in the form, structure or composition of any portion of their anatomy between the head and the tail compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
Allele: WBVar00241242   WBPaper00046712   Observed
embryonic lethal

"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
RNAi: WBRNAi00072290   WBPaper00029258   Observed
RNAi: WBRNAi00072291   WBPaper00029258   Observed
Allele: WBVar00241242   WBPaper00046712   Observed
head morphology variant

"Animals exhibit variations in the form, structure or composition of any portion of their anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring) compared to control." [WB:WBPerson2021, WB:WBPerson557]
Allele: WBPerson261   WBVar00241242   Observed
larval arrest

"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
RNAi: WBRNAi00073813   WBPaper00029258   Observed
larval lethal

"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
Allele: WBPerson261   WBVar00241242   Observed
protein aggregation variant

"Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
RNAi: WBRNAi00081636   WBPaper00034765   Observed
protruding vulva

"Animals undergo incomplete vulval morphogenesis, resulting in the formation of a single protrusion at the site of the vulva." [WB:WBPaper00004408, WB:WBPerson2021]
RNAi: WBRNAi00073810   WBPaper00029258   Observed
RNAi: WBRNAi00073811   WBPaper00029258   Observed
RNAi: WBRNAi00073812   WBPaper00029258   Observed
RNAi: WBRNAi00073813   WBPaper00029258   Observed
RNAi: WBRNAi00073814   WBPaper00029258   Observed
reduced brood size

"The characteristic number of offspring produced is lower compared to that of control animals." [WB:WBPerson557]
RNAi: WBRNAi00072290   WBPaper00029258   Observed
RNAi: WBRNAi00073813   WBPaper00029258   Observed
sterile

"Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712]
RNAi: WBRNAi00072290   WBPaper00029258   Observed
RNAi: WBRNAi00073810   WBPaper00029258   Observed
RNAi: WBRNAi00073811   WBPaper00029258   Observed
RNAi: WBRNAi00073812   WBPaper00029258   Observed
RNAi: WBRNAi00073813   WBPaper00029258   Observed
RNAi: WBRNAi00073814   WBPaper00029258   Observed
thin

"Animals exhibit a reduced girth compared to a control animal of the same developmental stage." [WB:WBPerson712]
RNAi: WBRNAi00073810   WBPaper00029258   Observed
RNAi: WBRNAi00073811   WBPaper00029258   Observed
RNAi: WBRNAi00073812   WBPaper00029258   Observed
RNAi: WBRNAi00073813   WBPaper00029258   Observed


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