JCEG ID JCEG059
Name hpo-3      WormBase
Human Ortholog

GGDB:GPAA1 

OMIM: 603048

OrthoList :   GPAA1  (Ensembl Compara)

Family Name GPI-anchor synthesis
Locus Tag F33D11.9
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Barberan-Soler S, Zahler AM PLoS Genet. (2008) 4 (2) :e1000001 [PMID : 18454200] Alternative splicing regulation during C. elegans development: splicing factors as regulated targets.

Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV PLoS Pathog. (2011) 7 (3) :e1001314 [PMID : 21408619] Global functional analyses of cellular responses to pore-forming toxins.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

WormBase (WS254)

Functional Descriptions hpo-3

Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00026980 : intestine_enriched
WBPaper00026980 WormAtlas
WB WBbt:0005784

germ line "cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes." [ISBN:0140512888] Enriched WBPaper00044760 : germline_specific
WBPaper00044760
WB WBbt:0006849

germline precursor cell "member of a set of two cells that generate exclusively sperm and ovum." [WB:rynl] Enriched WBPaper00037950 : germline-precursors_embryo_enriched
WBPaper00037950

WBGene00018006
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
Bacillus thuringiensis toxin hypersensitive

"Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
RNAi: WBRNAi00088582   WBPaper00038231   Observed
RNAi: WBRNAi00088689   WBPaper00038231   Observed
pore forming toxin hypersensitive

"Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557]
RNAi: WBRNAi00088582   WBPaper00038231   Observed
RNAi: WBRNAi00088689   WBPaper00038231   Observed


Top




Insert title here