JCEG ID |
JCEG054 |
Name |
T07D3.4
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:FCMD
OMIM:
253800
607440
611588
611615
613152
OrthoList :
FKTN
(Ensembl Compara)
GGDB |
Score |
E-val |
FCMD
|
97 |
5e-22 |
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
Fukutin |
Locus Tag |
T07D3.4
|
RNAi phenotype |
phenotype
|
WT
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
tm:Detected
dxd:Detected
kr:Detected
gg_motif:M1, M3, M6
|
Sequence |
CDS
atgttaatgattttccgacgtagaaggtataccatattcctttttcttct cattctagttctaattttatacatttgctcccgcaaacccagaaagccta aatacgggaggtttgccggtttgcaaaatgagacactactgccaaactct gctcgggtcccaatttaccacacaaactgcatttccatcctgaaccagat gaagctccccgtgccatttttgattattgatatcgattttttgaaaatgt tggataaaaattattgcaaatggagttcggatgaggttttaaaagttgct gtaaattcaaaatactctcctataaactattcaaattcaaaattggacat aattttctacgaaaacgactctgcaaaggactacttggatttaaaatcag aagttcgaagattaataccaaaaaaattccagactcactgggttgagaat atagaaattcccacaaatatcaaacagttcaccgagttttggaagcgctc aaagtttattgattgtttgaaactagaagttccgagagataaatcttatg tcttcatgccagctgaaccagctgtcgaggagctcgcccagctccgcgat gagctcatcgagtttgacatgtacccattccttaacggcggaacatttct cggctggtaccgtgagtgctctatcattccgcacactaccgacatggatt tatcggtctttgcgaaggattataacccaatctacgtggaattacttcac agctactggaatccgtctagtttcgaagtttggcgaatgctgggcatggt tgaggattctttcgagatcactatacaaacgaaaaagtggttcgagtacc caattgacttgtttctaatgtatgaaggaatcgaaaatgggaaacttacc catcattgggtgggcggaattgccaccgacggcaccaaatacaagttcac ctaccctatctacgatccttggtgtgcagcggatcttcacggtcatattt tctgggtctcctgtaatccactggagaaaattttggcagagtatggagaa gactggaaaaaggatcacctctcatccgagtacagatggaattattcgca gaaaaatgtgcaaacaaacgggaaatatacagcggagcagatgaagatgc tttatagaaaggctacaatcgggttccgtgctgtacacagagctttaaac tcatttatttctaggattcctattttataa
|
Protein
MLMIFRRRRYTIFLFLLILVLILYICSRKPRKPKYGRFAGLQNETLLPNSARVPIYHTNC ISILNQMKLPVPFLIIDIDFLKMLDKNYCKWSSDEVLKVAVNSKYSPINYSNSKLDIIFY ENDSAKDYLDLKSEVRRLIPKKFQTHWVENIEIPTNIKQFTEFWKRSKFIDCLKLEVPRD KSYVFMPAEPAVEELAQLRDELIEFDMYPFLNGGTFLGWYRECSIIPHTTDMDLSVFAKD YNPIYVELLHSYWNPSSFEVWRMLGMVEDSFEITIQTKKWFEYPIDLFLMYEGIENGKLT HHWVGGIATDGTKYKFTYPIYDPWCAADLHGHIFWVSCNPLEKILAEYGEDWKKDHLSSE YRWNYSQKNVQTNGKYTAEQMKMLYRKATIGFRAVHRALNSFISRIPIL
|
References |
|
Functional Descriptions |
T07D3.4
T07D3.4 is orthologous to the human gene, Fukutin (FKTN, also called FCMD).
|
Deletion Mutants |
ok664
|
In Situ |
In Situ
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0005451
|
pharyngeal muscle cell |
"type of cells that make up muscle layers in the pharynx." [WB:rynl] |
Enriched |
WBPaper00037950 : pharyngeal-muscle_embryo_enriched
|
WBPaper00037950
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00026980 : intestine_enriched
|
WBPaper00026980
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00037950 : intestine_CoreEnriched, intestine_embryo_enriched, intestine_larva_enriched
|
WBPaper00037950
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00040985 : AIN-2_L4_intestine, AIN-2_asynchronous_intestine
|
WBPaper00040985
|
WormAtlas
|
WB |
WBbt:0006819
|
AVE |
"Neuron class of two interneurons with cell bodies situated in the lateral ganglion close to the ring neuropile." [WB:Paper00000938] |
Enriched |
WBPaper00037950 : AVE-neuron_embryo_enriched
|
WBPaper00037950
|
|
WB |
WBbt:0006831
|
PVD |
"Neuron class of two interneurons with cell bodies situated laterally in the posterior body." [WB:Paper00000938] |
Enriched |
WBPaper00036375 : enriched_in_PVD_OLL
|
WBPaper00036375
|
|
WB |
WBbt:0006847
|
OLL |
"Neuron class of two neurons with ciliated endings in the lateral outer labial sensilla." [WB:Paper00000938] |
Enriched |
WBPaper00036375 : enriched_in_PVD_OLL
|
WBPaper00036375
|
|
|
WBGene00020307
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|