JCEG ID JCEG053
Name fut-8      WormBase    NCBI Gene
Human Ortholog

GGDB:FUT8 

OMIM: 602589

OrthoList :   FUT8  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
MAPPED 0.59 0.00000004 0.03 (unit increase) [0.02-0.04] 25231870
MAPPED 0.21 0.00000001 (DG6) 0.22 (unit decrease) [0.14-0.30] 21203500
GGDB Score E-val
FUT8 377 e-106
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name Fucosyltransferases
Locus Tag C10F3.6
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features tm:Detected
gg_motif:M1,M2,M5,M6
kr:Detected
Sequence CDS
Protein
References

Paschinger K, Staudacher E, Stemmer U, Fabini G, Wilson IB Glycobiology (2004) 15 (5) :463-74 [PMID : 15604090] Fucosyltransferase substrate specificity and the order of fucosylation in invertebrates.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Butschi A, Titz A, Walti MA, Olieric V, Paschinger K, Nobauer K, Guo X, Seeberger PH, Wilson IB, Aebi M, Hengartner MO, Kunzler M PLoS Pathog. (2010) 6 (1) :e1000717 [PMID : 20062796] Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.

Maduzia LL, Yu E, Zhang Y J. Biol. Chem. (2010) 286 (6) :4371-81 [PMID : 21115491] Caenorhabditis elegans galectins LEC-6 and LEC-10 interact with similar glycoconjugates in the intestine.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Yan S, Serna S, Reichardt NC, Paschinger K, Wilson IB J. Biol. Chem. (2013) 288 (29) :21015-28 [PMID : 23754284] Array-assisted characterization of a fucosyltransferase required for the biosynthesis of complex core modifications of nematode N-glycans.

WormBase (WS254)

Functional Descriptions fut-8

fut-8 encodes a core alpha 1,6-fucosyltransferase; characterization of a recombinant form of the protein that contains the catalytic region of FUT-8 reveals a sustrate requirement for unsubstituted nonreducing terminal GlcNAc residues.
Deletion Mutants ok2558
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0005751

coelomocyte "A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] Enriched WBPaper00037950 : coelomocytes_embryo_enriched
 WBPaper00037950 WormAtlas

WBGene00001508
Phenotype
Homology_paralog
Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele


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