JCEG ID JCEG052
Name fut-6      WormBase    NCBI Gene
Human Ortholog

GGDB:FUT6 FUT7 

OMIM:

OrthoList :   FUT7   FUT3   FUT5   FUT4   FUT6   FUT9  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
MAPPED 0.0000000000004 49.78 (pg/ml increase) [36.41-63.15] 22367966
MAPPED 0.0000000000000000008 24941225
MAPPED 0.38 (CA19-9) 0.282 (U/ml increase) [0.20-0.37] 23300138
MAPPED 0.33 0.00000000000000000000000000000000001 (CEA) 0.073 (ng/ml increase) [0.048-0.098] 23300138
MAPPED 0.33 (CA19-9) 0.481 (U/ml decrease) [0.44-0.52] 23300138
MAPPED 0.2 0.00000000000000000000000000000000000000000000000000000002 (CA19-9) 0.169 (U/ml decrease) [0.11-0.22] 23300138
MAPPED 0.11 0.0000000009 (DG12) 0.3 (unit decrease) [0.20-0.40] 21203500
MAPPED 0.11 0.000000000003 (DG7) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 0.000000000001 (FUC-A) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 0.00000000000000004 (DG9) 0.41 (unit decrease) [0.31-0.51] 21203500
GGDB Score E-val
FUT6 125 1e-30
FUT7 122 7e-30
FUT5 118 2e-28
FUT3 114 4e-27
FUT4 108 1e-25
FUT9 108 1e-25
FUT11 75 2e-15
FUT10 60 5e-11
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name Fucosyltransferases
Locus Tag T05A7.5
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features tm:Detected
kr:Detected
gg_motif:M1,M2,M3,M5
Sequence CDS
Protein
References

Paschinger K, Rendic D, Lochnit G, Jantsch V, Wilson IB J. Biol. Chem. (2004) 279 (48) :49588-98 [PMID : 15364955] Molecular basis of anti-horseradish peroxidase staining in Caenorhabditis elegans.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Nguyen K, van Die I, Grundahl KM, Kawar ZS, Cummings RD Glycobiology (2007) 17 (6) :586-99 [PMID : 17369288] Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Schubert M, Bleuler-Martinez S, Butschi A, Walti MA, Egloff P, Stutz K, Yan S, Collot M, Mallet JM, Wilson IB, Hengartner MO, Aebi M, Allain FH, Kunzler M PLoS Pathog. (2012) 8 (5) :e1002706 [PMID : 22615566] Plasticity of the β-trefoil protein fold in the recognition and control of invertebrate predators and parasites by a fungal defence system.

Yan S, Serna S, Reichardt NC, Paschinger K, Wilson IB J. Biol. Chem. (2013) 288 (29) :21015-28 [PMID : 23754284] Array-assisted characterization of a fucosyltransferase required for the biosynthesis of complex core modifications of nematode N-glycans.

WormBase (WS254)

Functional Descriptions fut-6

Deletion Mutants ok475
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00037950 : intestine_larva_SelectivelyEnriched, intestine_larva_enriched
WBPaper00037950 WormAtlas

WBGene00020222
Phenotype
Homology_paralog



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