JCEG ID JCEG050
Name fut-1      WormBase    NCBI Gene
Human Ortholog

GGDB:FUT5 FUT3 FUT4 FUT6 

OMIM: 104230 111100 111100 136835 136836 602030 606865 613852

OrthoList :   FUT7   FUT3   FUT5   FUT4   FUT6   FUT9  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.000004 (EA) 22566498
DOWNSTREAM 0.0000009 (EA) 1.4 (unit increase) [0.79-2.01] 22566498
MAPPED 0.00000003 24941225
MAPPED 0.0000000000004 49.78 (pg/ml increase) [36.41-63.15] 22367966
MAPPED 0.0000000000000000008 24941225
MAPPED 0.38 (CA19-9) 0.282 (U/ml increase) [0.20-0.37] 23300138
MAPPED 0.33 0.00000000000000000000000000000000001 (CEA) 0.073 (ng/ml increase) [0.048-0.098] 23300138
MAPPED 0.33 (CA19-9) 0.481 (U/ml decrease) [0.44-0.52] 23300138
MAPPED 0.2 0.00000000000000000000000000000000000000000000000000000002 (CA19-9) 0.169 (U/ml decrease) [0.11-0.22] 23300138
MAPPED 0.11 0.0000000009 (DG12) 0.3 (unit decrease) [0.20-0.40] 21203500
MAPPED 0.11 0.000000000003 (DG7) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 0.000000000001 (FUC-A) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 0.00000000000000004 (DG9) 0.41 (unit decrease) [0.31-0.51] 21203500
GGDB Score E-val
FUT5 136 5e-34
FUT6 135 2e-33
FUT3 131 2e-32
FUT4 118 2e-28
FUT7 111 2e-26
FUT9 100 5e-23
FUT11 82 1e-17
FUT10 81 3e-17
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name Fucosyltransferases
Locus Tag K08F8.3
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features kr:Detected
tm:Detected
gg_motif:M1,M2,M3,M4,M5
Sequence CDS
Protein
References

DeBose-Boyd RA, Nyame AK, Cummings RD Glycobiology (1998) 8 (9) :905-17 [PMID : 9675224] Molecular cloning and characterization of an alpha1,3 fucosyltransferase, CEFT-1, from Caenorhabditis elegans.

Paschinger K, Rendic D, Lochnit G, Jantsch V, Wilson IB J. Biol. Chem. (2004) 279 (48) :49588-98 [PMID : 15364955] Molecular basis of anti-horseradish peroxidase staining in Caenorhabditis elegans.

Paschinger K, Fabini G, Schuster D, RendiH D, Wilson IB Acta Biochim. Pol. (2005) 52 (3) :629-32 [PMID : 16175237] Definition of immunogenic carbohydrate epitopes.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Nguyen K, van Die I, Grundahl KM, Kawar ZS, Cummings RD Glycobiology (2007) 17 (6) :586-99 [PMID : 17369288] Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family.

Butschi A, Titz A, Walti MA, Olieric V, Paschinger K, Nobauer K, Guo X, Seeberger PH, Wilson IB, Aebi M, Hengartner MO, Kunzler M PLoS Pathog. (2010) 6 (1) :e1000717 [PMID : 20062796] Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.

Both P, Sobczak L, Breton C, Hann S, Nobauer K, Paschinger K, Kozmon S, Mucha J, Wilson IB Glycobiology (2011) 21 (11) :1401-15 [PMID : 21515584] Distantly related plant and nematode core α1,3-fucosyltransferases display similar trends in structure-function relationships.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Schubert M, Bleuler-Martinez S, Butschi A, Walti MA, Egloff P, Stutz K, Yan S, Collot M, Mallet JM, Wilson IB, Hengartner MO, Aebi M, Allain FH, Kunzler M PLoS Pathog. (2012) 8 (5) :e1002706 [PMID : 22615566] Plasticity of the β-trefoil protein fold in the recognition and control of invertebrate predators and parasites by a fungal defence system.

Yan S, Serna S, Reichardt NC, Paschinger K, Wilson IB J. Biol. Chem. (2013) 288 (29) :21015-28 [PMID : 23754284] Array-assisted characterization of a fucosyltransferase required for the biosynthesis of complex core modifications of nematode N-glycans.

WormBase (WS254)

Functional Descriptions fut-1

fut-1 encodes a functional fucosyl transferase; evidence from biophysical experiments indicates that FUT-1 is a golgi-localized glycosyltransferase.
Deletion Mutants gk183 ok892
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00030839 : Embryo_Pan_Neuronal
WBPaper00030839 WormAtlas
WB WBbt:0003891

ASGR "one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil" [ISBN:0-87969-307-X] Certain WB:Expr4985 WBPaper00029194 WormAtlas
WB WBbt:0003892

ASGL "one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil" [ISBN:0-87969-307-X] Certain WB:Expr4985 WBPaper00029194 WormAtlas
WB WBbt:0004364

PHBL "Phasmid neurons, probably chemosensory" [ISBN:0-87969-307-X] Certain WB:Expr4985 WBPaper00029194 WormAtlas
WB WBbt:0004365

PHAR "Phasmid neurons, probably chemosensory" [ISBN:0-87969-307-X] Certain WB:Expr4985 WBPaper00029194 WormAtlas
WB WBbt:0004366

PHAL "Phasmid neurons, probably chemosensory" [ISBN:0-87969-307-X] Certain WB:Expr4985 WBPaper00029194 WormAtlas
WB WBbt:0004510

virR "Intestino-rectal valve" [ISBN:0-87969-307-X] Certain WB:Expr4985 WBPaper00029194 WormAtlas
WB WBbt:0004511

virL "Intestino-rectal valve" [ISBN:0-87969-307-X] Certain WB:Expr4985 WBPaper00029194 WormAtlas
WB WBbt:0005406

ALM "Neuron class of two anterior sensory neurons that transduce touch stimuli." [WB:Paper00000938] Enriched WBPaper00040420 : ALM_PLM_enriched
WBPaper00040420
WB WBbt:0005490

PLM "Neuron class of two posterior sensory neurons that transduce touch stimuli." [WB:Paper00000938] Enriched WBPaper00040420 : ALM_PLM_enriched
WBPaper00040420
WB WBbt:0005656

retrovesicular ganglion "ganglion that lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore. It is open and continuous with the region containing the motoneurons of the ventral cord. In the early L1 this ganglion holds 12 neuron cell bodies plus one neuroblast (Sulston and Horvitz, 1977; White et al., 1986). In the adult animal, the ganglion holds 20 neuron cell bodies.\nReversal \n\n" [WBPaper:00038216] Partial WB:Expr4985 WBPaper00029194 WormAtlas
WB WBbt:0005659

PHBR "Phasmid neuron, probably chemosensory" [ISBN:0-87969-307-X] Certain WB:Expr4985 WBPaper00029194 WormAtlas
WB WBbt:0005767

pharyngeal-intestinal valve "A group of six equivalent cells forms a tightly constructed 'valve' that links the posterior bulb of the pharynx to the anterior four cells of the intestine. These six cells comprise a small epithelial channel with a cuticular lining in continuity with the pharyngeal cuticle and link the lumen of the pharynx to the large lumen of the anterior intestine." [WBPaper:00038216] Certain WB:Expr4985 WBPaper00029194 WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00037950 : intestine_larva_SelectivelyEnriched, intestine_larva_enriched
WBPaper00037950 WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00040985 : AIN-2_L4_intestine
WBPaper00040985 WormAtlas
WB WBbt:0006828

FLP "Neuron class of two neurons, which have ciliated endings situated immediately dorsal to the lateral inner labial sensilla in the head but have no associated sheath or socket cells; they have flattened processes in this region of the cilium." [WB:Paper00000938] Enriched WBPaper00040420 : FLP_enriched
WBPaper00040420
WB WBbt:0006831

PVD "Neuron class of two interneurons with cell bodies situated laterally in the posterior body." [WB:Paper00000938] Enriched WBPaper00036375 : enriched_in_PVD_OLL
WBPaper00036375
WB WBbt:0006847

OLL "Neuron class of two neurons with ciliated endings in the lateral outer labial sensilla." [WB:Paper00000938] Enriched WBPaper00036375 : enriched_in_PVD_OLL
WBPaper00036375

WBGene00001505
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele


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