JCEG ID |
JCEG049 |
Name |
fut-3
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:FUT5 FUT1 FUT10 FUT11
OMIM:
OrthoList :
FUT7
FUT3
FUT5
FUT4
FUT6
FUT9
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
Fucosyltransferases |
Locus Tag |
F59E12.13
|
RNAi phenotype |
phenotype
|
WT
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
kr:Detected
tm:Detected
gg_motif:M1,M2,M3,M4,M5
|
Sequence |
CDS
atgagggttcggccagcaagtgtctatcgatacctgcttctcggtgtttg cgctcttctcggtatctacacagtatactcgattatcggatatgatgatg gatcacacgttccaattcacagaccacaacgtcatctttacctaacagta tctcaggatagaatcggtagccgttttgggaaacttgccccgaaacgaat tctatactggactacaatattcggtgcaactgttccttcaactgctcttt cagactgtccaggattaacggatcgttgtgtaattgatacaaatcgccat caattggattcggctgatgctgtcgtatttcatgctgctgatatttcaaa gtttcctctgcctgtctcgaggaaacctgaccaaatttttgtcttcaact caatggaaacccctgataatagtggtcgttttgcagttccagatggattt ttcaactggacatcaactcatctttactcttccgacgcgattcataaata cggaacatttttgattccaactcaaattgcagaaagtcgaggattcaaag tgcaaagttactatgtgcaaccgaaaagactagtgaaaacgatgaaagga atattcgggctcatttccaattgtcatacaaaatcaaaaagagaacttgc acttcaggaactcggaaaacatatcaatgtaacaattggaggaaaatgtg catccgatgatcgacttaaatctatttgtcctgctggagtagagtgcatt gatgtattcgagcagtatccattctacattgcgatcgagaatacggtgtg taatgactacgtgactgaaaagatttggtctcgaatcaccgttccaagca ttccaattgtgatgagacgaagagtgtatcaaaatatacttcctccaaaa tcgttcattgccatggatgactacaagaatccttccgaaatggccaatca tctcagatctctcgaggccaattcaactgcctatggagaatattttgaat ggcgtcaaaagggtttatggacttctgctccttggaacgctcctggatat cgcaatggattgtgccgtgtctgtgagcttctctggaaagcgaaagataa cgaaacagaagtttataaatcgtacgacaacatttggaaatggtttgaca acgaatctcaatgcgaaacggacgaattcgtgcgcagttggctcagtggt tag
|
Protein
MRVRPASVYRYLLLGVCALLGIYTVYSIIGYDDGSHVPIHRPQRHLYLTVSQDRIGSRFG KLAPKRILYWTTIFGATVPSTALSDCPGLTDRCVIDTNRHQLDSADAVVFHAADISKFPL PVSRKPDQIFVFNSMETPDNSGRFAVPDGFFNWTSTHLYSSDAIHKYGTFLIPTQIAESR GFKVQSYYVQPKRLVKTMKGIFGLISNCHTKSKRELALQELGKHINVTIGGKCASDDRLK SICPAGVECIDVFEQYPFYIAIENTVCNDYVTEKIWSRITVPSIPIVMRRRVYQNILPPK SFIAMDDYKNPSEMANHLRSLEANSTAYGEYFEWRQKGLWTSAPWNAPGYRNGLCRVCEL LWKAKDNETEVYKSYDNIWKWFDNESQCETDEFVRSWLSG
|
References |
Paschinger K, Rendic D, Lochnit G, Jantsch V, Wilson IB
J. Biol. Chem.
(2004)
279
(48)
:49588-98
[PMID : 15364955]
Molecular basis of anti-horseradish peroxidase staining in Caenorhabditis elegans.
Berninsone PM
WormBook
(2006)
:1-22
[PMID : 18050430]
Carbohydrates and glycosylation.
Nguyen K, van Die I, Grundahl KM, Kawar ZS, Cummings RD
Glycobiology
(2007)
17
(6)
:586-99
[PMID : 17369288]
Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
fut-3
|
Deletion Mutants |
gk103
|
In Situ |
In Situ
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00030839 : Embryo_Pan_Neuronal
|
WBPaper00030839
|
WormAtlas
|
WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00031532 : Larva_Pan_Neuronal_Enriched
|
WBPaper00031532
|
WormAtlas
|
WB |
WBbt:0005784
|
germ line |
"cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes." [ISBN:0140512888] |
Enriched |
WBPaper00044760 : germline_specific
|
WBPaper00044760
|
|
|
WBGene00006402
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|