JCEG ID JCEG018
Name C38H2.2      WormBase    NCBI Gene
Human Ortholog

GGDB:C1GALT1 

OMIM: 300611 300622

OrthoList :   C1GALT1  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.0000002 (PCB105) 1.32 (unit decrease) [0.83-1.81] 25839716
MAPPED 0.46 0.000004 [NR] 19010793
MAPPED 0.444 0.000001 0.099 (unit decrease) [0.06-0.138] 24159190
MAPPED 0.444 0.0000006 0.101 (unit increase) [0.062-0.14] 24159190
GGDB Score E-val
C1GALT1 334 2e-93
C1GALT1C1 129 1e-31
CHSY1 72 2e-14
CSS3 71 3e-14
B3GLCT 64 5e-12
CSGlcA-T 48 2e-07
CHPF 46 9e-07
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name Core 1 GalT
Locus Tag C38H2.2
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features kr:Detected
tm:Detected
dxd:DDD
gg_motif:M1,M2,M3,M4,M5,M6
Sequence CDS
Protein
References

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Ju T, Zheng Q, Cummings RD Glycobiology (2006) 16 (10) :947-58 [PMID : 16762980] Identification of core 1 O-glycan T-synthase from Caenorhabditis elegans.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

WormBase (WS254)

Functional Descriptions C38H2.2

C38H2.2 encodes a core 1 UDP-Gal:GalNAcalpha1-Ser/Thr beta1,3-galactosyltransferase (core 1 beta3-Gal-T or T-synthase, EC2.4.1.122); C38H2.2 protein is predicted to be primarily extracellular, with an N-terminal transmembrane domain; C38H2.2 shares 6 conserved cysteine residues with all known T-synthases, and is ubiquitously expressed; enzymatically active C38H2.2 can be generated from insect but not mammalian cells, suggesting that invertebrate-specific chaperones are required for its activity.
Deletion Mutants ok2175
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00031532 : Larva_Pan_Neuronal_Enriched
WBPaper00031532 WormAtlas
WB WBbt:0003681

pharynx "the feeding organ, a neuro-muscular pump in the head of the animal, used to ingest food, bacteria suspended in liquid, filter them out, grind them up and transport posteriorly into the instestine." [WB:rynl] WB:Expr5473 WBPaper00006525 WormAtlas
WB WBbt:0003681

pharynx "the feeding organ, a neuro-muscular pump in the head of the animal, used to ingest food, bacteria suspended in liquid, filter them out, grind them up and transport posteriorly into the instestine." [WB:rynl] Enriched WBPaper00029359 WormAtlas
WB WBbt:0004017

Cell "a cellular object that consists of subcellular components, expresses genes or functions." [WB:rynl] Certain WB:Expr4234 WBPaper00027670
WB WBbt:0005319

spermatheca "an accordion-like tube that contains sperm and is the site of oocyte fertilization." [WBPaper:00038216] WB:Expr5473 WBPaper00006525 WormAtlas
WB WBbt:0005735

nervous system "Complement of nervous tissue (neurones, nerves, receptors and support cells) serving to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities." [ISBN:0-14-051288-8, WB:rynl] WB:Expr5473 WBPaper00006525 WormAtlas
WB WBbt:0005738

body region "region of the body by which tissues, cells or cell parts are classified" [WBPaper:00038216] Partial WB:Expr5473 WBPaper00006525
WB WBbt:0005741

tail "posterior region, from rectum to the end" [WB:rynl] Partial WB:Expr5473 WBPaper00006525 WormAtlas
WB WBbt:0005747

reproductive system WB:Expr5473 WBPaper00006525
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] WB:Expr5473 WBPaper00006525 WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00029359 WormAtlas
WB WBbt:0005788

pharyngeal gland cell "secretory gland cell of the pharynx" [WB:rynl] WB:Expr5473 WBPaper00006525 WormAtlas
WB WBbt:0005799

rectal gland cell WB:Expr5473 WBPaper00006525 WormAtlas
WB WBbt:0005813

body wall musculature "Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] Enriched WBPaper00029359 WormAtlas
WB WBbt:0006748

vulva "female genital." [WB:rynl] WB:Expr5473 WBPaper00006525 WormAtlas
WB WBbt:0006751

head neuron "neuron with its cell body situated in the head, excluding the pharynx." [WB:rynl] WB:Expr5473 WBPaper00006525

WBGene00008019
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele


Top




Insert title here