JCEG ID |
JCEG015 |
Name |
algn-14
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:ALG14
OMIM:
612866
OrthoList :
ALG14
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
|
0.00000005
(proportions)
|
|
0.7
(% increase)
|
[NR] |
22359512
|
|
Demirkan A 2012-02-16 PLoS Genet
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
|
MAPPED |
0.49 |
0.000000000000000002
|
|
0.1651
(unit decrease)
|
[0.128-0.202] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
MAPPED |
0.451 |
0.00000000003
|
|
0.178
(unit incease)
|
[0.125-0.23] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
GGDB |
Score |
E-val |
ALG14
|
162 |
5e-42 |
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
Asparagine-linked glycosylation (ALG) genes |
Locus Tag |
M02B7.4
|
RNAi phenotype |
phenotype
|
Emb, hsp-4::GFP increase
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Increase
|
hsp-4::GFP (Image)
|
Increase
|
|
Sequence Features |
kr:Detected
dxd:DTD
tm:Detected
|
Sequence |
CDS
atgttttttctatttttcttcgtcacagctgtaatattattcggtgtgct atgtctgacagcatttatggcatttcaagtccgccattcgaatcattcgg cgaaaaatatgccgaaaaaagatacagcatcattatgcgtagttcttggt tcgggaggtcacaccagcgagatgatggagctcgtcaagcattttggcga ggaattcgacgagagaacctacataattgcggatacagacacgatgagcg aggataaggcaataaatcacgaaaaatcgaggaataacgagaaattctgc atcgaaaagattccgagatctcgggaagtcggacaatcctacttgacgtc gattggctcaactatcaacgcaaccgcgttcgccgtgaagcttatctaca gaattcgtccggatctaatcgtgctcaacgggcctggaacctgtatccca gtcgccttggcggccgccttcttcgacataattcgcctaatcgatacagt tattatctacgaagaatcgatttgccgagtgaaaaagctctccttatccg gatttggagcacaaattcacgttggatggctcggagaaaaaatctcaata aaaatattaatttatgtgtcaattttaggggggattttgtttttaaatag aaaaaaccttttaattaaaaaaacacagaaagatggaaatttggaaaaaa tgatttttgtgatttttgcaaattttggaaaattcgtttttttttcaaaa caaaatgaatttcacctttttaaaaattcagcaaaaatttttttccaaaa attcacgtttttttacggatttcctctaaaaaatcattga
|
Protein
MFFLFFFVTAVILFGVLCLTAFMAFQVRHSNHSAKNMPKKDTASLCVVLGSGGHTSEMME LVKHFGEEFDERTYIIADTDTMSEDKAINHEKSRNNEKFCIEKIPRSREVGQSYLTSIGS TINATAFAVKLIYRIRPDLIVLNGPGTCIPVALAAAFFDIIRLIDTVIIYEESICRVKKL SLSGFGAQIHVGWLGEKISIKILIYVSILGGILFLNRKNLLIKKTQKDGNLEKMIFVIFA NFGKFVFFSKQNEFHLFKNSAKIFFQKFTFFYGFPLKNH
|
References |
Bartschat S, Samuelsson T
BMC Genomics
(2010)
11
:106
[PMID : 20149226]
U12 type introns were lost at multiple occasions during evolution.
Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV
PLoS Pathog.
(2011)
7
(3)
:e1001314
[PMID : 21408619]
Global functional analyses of cellular responses to pore-forming toxins.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
algn-14
|
Deletion Mutants |
|
In Situ |
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0004740
|
I5 neuron |
"Neuron class of one pharyngeal interneuron, posterior sensory." [ISBN:0-87969-307-X] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
|
WB |
WBbt:0005278
|
DA neuron |
"Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
|
WB |
WBbt:0005278
|
DA neuron |
"Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] |
Enriched |
WBPaper00030839 : Embryo_A_Class
|
WBPaper00030839
|
|
WB |
WBbt:0005396
|
SAB |
"Neuron class of three interneurons, which send processes anteriorly up the sub-lateral cords in the head." [WB:Paper00000938] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
|
WB |
WBbt:0005656
|
retrovesicular ganglion |
"ganglion that lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore. It is open and continuous with the region containing the motoneurons of the ventral cord. In the early L1 this ganglion holds 12 neuron cell bodies plus one neuroblast (Sulston and Horvitz, 1977; White et al., 1986). In the adult animal, the ganglion holds 20 neuron cell bodies.\nReversal \n\n" [WBPaper:00038216] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
WormAtlas
|
WB |
WBbt:0005784
|
germ line |
"cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes." [ISBN:0140512888] |
Enriched |
WBPaper00044760 : germline_specific
|
WBPaper00044760
|
|
|
WBGene00019725
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
Bacillus thuringiensis toxin hypersensitive
|
"Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
|
|
dauer lifespan extended
|
"The life span of dauer-staged animals is longer than that observed in control dauer animals." [WB:WBPaper00032396, WB:WBPerson2987]
|
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
pore forming toxin hypersensitive
|
"Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|