JCEG ID JCEG015
Name algn-14      WormBase    NCBI Gene
Human Ortholog

GGDB:ALG14 

OMIM: 612866

OrthoList :   ALG14  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
UPSTREAM 0.00000005 (proportions) 0.7 (% increase) [NR] 22359512
MAPPED 0.49 0.000000000000000002 0.1651 (unit decrease) [0.128-0.202] 23362303
MAPPED 0.451 0.00000000003 0.178 (unit incease) [0.125-0.23] 23362303
GGDB Score E-val
ALG14 162 5e-42
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name Asparagine-linked glycosylation (ALG) genes
Locus Tag M02B7.4
RNAi phenotype
phenotype Emb, hsp-4::GFP increase
Microscope observation (Image)
COPAS (Image)

Increase

hsp-4::GFP (Image)

Increase

Sequence Features kr:Detected
dxd:DTD
tm:Detected
Sequence CDS
Protein
References

Bartschat S, Samuelsson T BMC Genomics (2010) 11 :106 [PMID : 20149226] U12 type introns were lost at multiple occasions during evolution.

Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV PLoS Pathog. (2011) 7 (3) :e1001314 [PMID : 21408619] Global functional analyses of cellular responses to pore-forming toxins.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

WormBase (WS254)

Functional Descriptions algn-14

Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0004740

I5 neuron "Neuron class of one pharyngeal interneuron, posterior sensory." [ISBN:0-87969-307-X] Enriched WBPaper00025141 : unc-4
WBPaper00025141
WB WBbt:0005278

DA neuron "Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] Enriched WBPaper00025141 : unc-4
WBPaper00025141
WB WBbt:0005278

DA neuron "Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] Enriched WBPaper00030839 : Embryo_A_Class
WBPaper00030839
WB WBbt:0005396

SAB "Neuron class of three interneurons, which send processes anteriorly up the sub-lateral cords in the head." [WB:Paper00000938] Enriched WBPaper00025141 : unc-4
WBPaper00025141
WB WBbt:0005656

retrovesicular ganglion "ganglion that lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore. It is open and continuous with the region containing the motoneurons of the ventral cord. In the early L1 this ganglion holds 12 neuron cell bodies plus one neuroblast (Sulston and Horvitz, 1977; White et al., 1986). In the adult animal, the ganglion holds 20 neuron cell bodies.\nReversal \n\n" [WBPaper:00038216] Enriched WBPaper00025141 : unc-4
WBPaper00025141 WormAtlas
WB WBbt:0005784

germ line "cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes." [ISBN:0140512888] Enriched WBPaper00044760 : germline_specific
WBPaper00044760

WBGene00019725
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
Bacillus thuringiensis toxin hypersensitive

"Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
RNAi: WBRNAi00088634   WBPaper00038231   Observed
RNAi: WBRNAi00088741   WBPaper00038231   Observed
dauer lifespan extended

"The life span of dauer-staged animals is longer than that observed in control dauer animals." [WB:WBPaper00032396, WB:WBPerson2987]
RNAi: WBRNAi00103458   WBPaper00041478   Observed
pore forming toxin hypersensitive

"Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557]
RNAi: WBRNAi00088634   WBPaper00038231   Observed
RNAi: WBRNAi00088741   WBPaper00038231   Observed


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